Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show that follistatin regulates insulin-induced suppressio...

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Autores principales: Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali, Olle Melander, Marju Orho-Melander, Jan Nilsson, Hans-Ulrich Häring, Erik Renström, Claes B. Wollheim, Gunnar Engström, Jianping Weng, Ewan R. Pearson, Paul W. Franks, Morris F. White, Kevin L. Duffin, Allan Arthur Vaag, Markku Laakso, Norbert Stefan, Leif Groop, Yang De Marinis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/718976e80f5648f99659b5ea904f47e5
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spelling oai:doaj.org-article:718976e80f5648f99659b5ea904f47e52021-11-14T12:34:14ZElevated circulating follistatin associates with an increased risk of type 2 diabetes10.1038/s41467-021-26536-w2041-1723https://doaj.org/article/718976e80f5648f99659b5ea904f47e52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26536-whttps://doaj.org/toc/2041-1723Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show that follistatin regulates insulin-induced suppression lipolysis in cultured human adipocytes.Chuanyan WuYan BornéRui GaoMaykel López RodriguezWilliam C. RoellJonathan M. WilsonAjit RegmiCheng LuanDina Mansour AlyAndreas PeterJürgen MachannHarald StaigerAndreas FritscheAndreas L. BirkenfeldRongya TaoRobert WagnerMickaël CanouilMun-Gwan HongJochen M. SchwenkEmma AhlqvistMinna U. KaikkonenPeter NilssonAngela C. ShoreFaisel KhanAndrea NataliOlle MelanderMarju Orho-MelanderJan NilssonHans-Ulrich HäringErik RenströmClaes B. WollheimGunnar EngströmJianping WengEwan R. PearsonPaul W. FranksMorris F. WhiteKevin L. DuffinAllan Arthur VaagMarkku LaaksoNorbert StefanLeif GroopYang De MarinisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chuanyan Wu
Yan Borné
Rui Gao
Maykel López Rodriguez
William C. Roell
Jonathan M. Wilson
Ajit Regmi
Cheng Luan
Dina Mansour Aly
Andreas Peter
Jürgen Machann
Harald Staiger
Andreas Fritsche
Andreas L. Birkenfeld
Rongya Tao
Robert Wagner
Mickaël Canouil
Mun-Gwan Hong
Jochen M. Schwenk
Emma Ahlqvist
Minna U. Kaikkonen
Peter Nilsson
Angela C. Shore
Faisel Khan
Andrea Natali
Olle Melander
Marju Orho-Melander
Jan Nilsson
Hans-Ulrich Häring
Erik Renström
Claes B. Wollheim
Gunnar Engström
Jianping Weng
Ewan R. Pearson
Paul W. Franks
Morris F. White
Kevin L. Duffin
Allan Arthur Vaag
Markku Laakso
Norbert Stefan
Leif Groop
Yang De Marinis
Elevated circulating follistatin associates with an increased risk of type 2 diabetes
description Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show that follistatin regulates insulin-induced suppression lipolysis in cultured human adipocytes.
format article
author Chuanyan Wu
Yan Borné
Rui Gao
Maykel López Rodriguez
William C. Roell
Jonathan M. Wilson
Ajit Regmi
Cheng Luan
Dina Mansour Aly
Andreas Peter
Jürgen Machann
Harald Staiger
Andreas Fritsche
Andreas L. Birkenfeld
Rongya Tao
Robert Wagner
Mickaël Canouil
Mun-Gwan Hong
Jochen M. Schwenk
Emma Ahlqvist
Minna U. Kaikkonen
Peter Nilsson
Angela C. Shore
Faisel Khan
Andrea Natali
Olle Melander
Marju Orho-Melander
Jan Nilsson
Hans-Ulrich Häring
Erik Renström
Claes B. Wollheim
Gunnar Engström
Jianping Weng
Ewan R. Pearson
Paul W. Franks
Morris F. White
Kevin L. Duffin
Allan Arthur Vaag
Markku Laakso
Norbert Stefan
Leif Groop
Yang De Marinis
author_facet Chuanyan Wu
Yan Borné
Rui Gao
Maykel López Rodriguez
William C. Roell
Jonathan M. Wilson
Ajit Regmi
Cheng Luan
Dina Mansour Aly
Andreas Peter
Jürgen Machann
Harald Staiger
Andreas Fritsche
Andreas L. Birkenfeld
Rongya Tao
Robert Wagner
Mickaël Canouil
Mun-Gwan Hong
Jochen M. Schwenk
Emma Ahlqvist
Minna U. Kaikkonen
Peter Nilsson
Angela C. Shore
Faisel Khan
Andrea Natali
Olle Melander
Marju Orho-Melander
Jan Nilsson
Hans-Ulrich Häring
Erik Renström
Claes B. Wollheim
Gunnar Engström
Jianping Weng
Ewan R. Pearson
Paul W. Franks
Morris F. White
Kevin L. Duffin
Allan Arthur Vaag
Markku Laakso
Norbert Stefan
Leif Groop
Yang De Marinis
author_sort Chuanyan Wu
title Elevated circulating follistatin associates with an increased risk of type 2 diabetes
title_short Elevated circulating follistatin associates with an increased risk of type 2 diabetes
title_full Elevated circulating follistatin associates with an increased risk of type 2 diabetes
title_fullStr Elevated circulating follistatin associates with an increased risk of type 2 diabetes
title_full_unstemmed Elevated circulating follistatin associates with an increased risk of type 2 diabetes
title_sort elevated circulating follistatin associates with an increased risk of type 2 diabetes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/718976e80f5648f99659b5ea904f47e5
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