Medical History, Clinical Features, Treatment Outcome and Its Predictors Among Infectious Keratitis Patients in Jimma University Medical Center, Southwest Ethiopia: Prospective Observational Study

Tolcha Regasa Dago,1 Dagmawit Kifle Woldemichael,2 Fekede Bekele Daba3 1School of Pharmacy, College of Medicine and Health Science, Mizan Tepi University, Mizan-Aman, Ethiopia; 2Department of Ophthalmology, Institute of Health, Jimma University, Jimma, Ethiopia; 3School of Pharmacy, Institute of Hea...

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Autores principales:	Dago TR, Woldemichael DK, Daba FB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	microbes infectious keratitis treatment outcome risk factors ethiopia Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/718ac03fa9654f2dabd412fd205dac5a
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spelling	oai:doaj.org-article:718ac03fa9654f2dabd412fd205dac5a2021-12-02T17:05:58ZMedical History, Clinical Features, Treatment Outcome and Its Predictors Among Infectious Keratitis Patients in Jimma University Medical Center, Southwest Ethiopia: Prospective Observational Study1177-5483https://doaj.org/article/718ac03fa9654f2dabd412fd205dac5a2021-03-01T00:00:00Zhttps://www.dovepress.com/medical-history-clinical-features-treatment-outcome-and-its-predictors-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tolcha Regasa Dago,1 Dagmawit Kifle Woldemichael,2 Fekede Bekele Daba3 1School of Pharmacy, College of Medicine and Health Science, Mizan Tepi University, Mizan-Aman, Ethiopia; 2Department of Ophthalmology, Institute of Health, Jimma University, Jimma, Ethiopia; 3School of Pharmacy, Institute of Health, Jimma University, Jimma, EthiopiaCorrespondence: Tolcha Regasa DagoMizan-Tepi University, P.O Box 260 Tel +251917233151Email negasatolosa@gmail.comBackground: Infectious keratitis is a major global cause of visual impairment and irreversible blindness among the corneal diseases. Its diagnosis and management remain getting challenge. The clinical and visual outcome remains poor in developing countries. The aim of this study was to determine treatment outcome and its predictors among patients with infectious keratitis.Methods: Prospective observational study was conducted among adult patients diagnosed with infectious keratitis at the Ophthalmology Department in Jimma University Medical Center from April 1 to September 30, 2019. The primary outcome indicator was response of the ulcer to empirical treatment. Ulcers that did not heal and required surgery had a poor outcome. Variables with a p-value of < 0.25 were entered into a multivariate logistic regression model to determine the independent predictors of poor treatment outcome and variables with a p-value of < 0.05 were considered statistically significant.Results: The research involved 131 adult patients. Eighty-seven (66.4%) were males. The mean age was 39.38 (± 18.9) years. Eighty-three (63.4%) patients had poor treatment outcome. Mean length of hospital stay was 17.38 (± 12.563) days. Poor visual outcome was observed among 71 (54.2%) participants. Evisceration was done for seven (5.3%) patients. Independent predictors of poor treatment outcome include perforation at admission (AOR=6.1, 95%CI: 1.5– 25.1), presence of comorbidity (AOR=7.7, 95%CI: 2.16– 27.3), poor adherence (AOR=5.3, 95%CI: 1.8– 25.9), traditional medicine use (AOR=6.7, 95%CI: 1.8– 25.4), ulcer depth > 1/3 (AOR=7.6, 95%CI: 2.48– 48.23) and farm workers (AOR=3.59, 95%CI: 1.09– 11.77). Major complications occurred after admissions were perforation (14.5%), followed by endophthalmitis (7.63%) and corneal opacity (6.87%).Conclusion and Recommendation: Our study found high poor treatment outcomes and high poor visual outcomes. Presence of comorbidity, perforation at admission, traditional medicine use, working on a farm, poor adherence, and ulcer depth were the predictors of poor treatment outcome. This high poor outcome requires a nationwide interventional study and urgent intervention that may reach rural communities.Keywords: microbes, infectious keratitis, treatment outcome, risk factors, EthiopiaDago TRWoldemichael DKDaba FBDove Medical Pressarticlemicrobesinfectious keratitistreatment outcomerisk factorsethiopiaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1223-1237 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microbes infectious keratitis treatment outcome risk factors ethiopia Ophthalmology RE1-994
spellingShingle	microbes infectious keratitis treatment outcome risk factors ethiopia Ophthalmology RE1-994 Dago TR Woldemichael DK Daba FB Medical History, Clinical Features, Treatment Outcome and Its Predictors Among Infectious Keratitis Patients in Jimma University Medical Center, Southwest Ethiopia: Prospective Observational Study
description	Tolcha Regasa Dago,1 Dagmawit Kifle Woldemichael,2 Fekede Bekele Daba3 1School of Pharmacy, College of Medicine and Health Science, Mizan Tepi University, Mizan-Aman, Ethiopia; 2Department of Ophthalmology, Institute of Health, Jimma University, Jimma, Ethiopia; 3School of Pharmacy, Institute of Health, Jimma University, Jimma, EthiopiaCorrespondence: Tolcha Regasa DagoMizan-Tepi University, P.O Box 260 Tel +251917233151Email negasatolosa@gmail.comBackground: Infectious keratitis is a major global cause of visual impairment and irreversible blindness among the corneal diseases. Its diagnosis and management remain getting challenge. The clinical and visual outcome remains poor in developing countries. The aim of this study was to determine treatment outcome and its predictors among patients with infectious keratitis.Methods: Prospective observational study was conducted among adult patients diagnosed with infectious keratitis at the Ophthalmology Department in Jimma University Medical Center from April 1 to September 30, 2019. The primary outcome indicator was response of the ulcer to empirical treatment. Ulcers that did not heal and required surgery had a poor outcome. Variables with a p-value of < 0.25 were entered into a multivariate logistic regression model to determine the independent predictors of poor treatment outcome and variables with a p-value of < 0.05 were considered statistically significant.Results: The research involved 131 adult patients. Eighty-seven (66.4%) were males. The mean age was 39.38 (± 18.9) years. Eighty-three (63.4%) patients had poor treatment outcome. Mean length of hospital stay was 17.38 (± 12.563) days. Poor visual outcome was observed among 71 (54.2%) participants. Evisceration was done for seven (5.3%) patients. Independent predictors of poor treatment outcome include perforation at admission (AOR=6.1, 95%CI: 1.5– 25.1), presence of comorbidity (AOR=7.7, 95%CI: 2.16– 27.3), poor adherence (AOR=5.3, 95%CI: 1.8– 25.9), traditional medicine use (AOR=6.7, 95%CI: 1.8– 25.4), ulcer depth > 1/3 (AOR=7.6, 95%CI: 2.48– 48.23) and farm workers (AOR=3.59, 95%CI: 1.09– 11.77). Major complications occurred after admissions were perforation (14.5%), followed by endophthalmitis (7.63%) and corneal opacity (6.87%).Conclusion and Recommendation: Our study found high poor treatment outcomes and high poor visual outcomes. Presence of comorbidity, perforation at admission, traditional medicine use, working on a farm, poor adherence, and ulcer depth were the predictors of poor treatment outcome. This high poor outcome requires a nationwide interventional study and urgent intervention that may reach rural communities.Keywords: microbes, infectious keratitis, treatment outcome, risk factors, Ethiopia
format	article
author	Dago TR Woldemichael DK Daba FB
author_facet	Dago TR Woldemichael DK Daba FB
author_sort	Dago TR
title	Medical History, Clinical Features, Treatment Outcome and Its Predictors Among Infectious Keratitis Patients in Jimma University Medical Center, Southwest Ethiopia: Prospective Observational Study
title_short	Medical History, Clinical Features, Treatment Outcome and Its Predictors Among Infectious Keratitis Patients in Jimma University Medical Center, Southwest Ethiopia: Prospective Observational Study
title_full	Medical History, Clinical Features, Treatment Outcome and Its Predictors Among Infectious Keratitis Patients in Jimma University Medical Center, Southwest Ethiopia: Prospective Observational Study
title_fullStr	Medical History, Clinical Features, Treatment Outcome and Its Predictors Among Infectious Keratitis Patients in Jimma University Medical Center, Southwest Ethiopia: Prospective Observational Study
title_full_unstemmed	Medical History, Clinical Features, Treatment Outcome and Its Predictors Among Infectious Keratitis Patients in Jimma University Medical Center, Southwest Ethiopia: Prospective Observational Study
title_sort	medical history, clinical features, treatment outcome and its predictors among infectious keratitis patients in jimma university medical center, southwest ethiopia: prospective observational study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/718ac03fa9654f2dabd412fd205dac5a
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Medical History, Clinical Features, Treatment Outcome and Its Predictors Among Infectious Keratitis Patients in Jimma University Medical Center, Southwest Ethiopia: Prospective Observational Study

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