Structural insights on ligand recognition at the human leukotriene B4 receptor 1

Human leukotriene B4 receptors (BLT1 and BLT2) are members of the GPCR superfamily that respond to a potent pro-inflammatory lipid and chemoattractant LTB4. Here authors determined a crystal structure of the human BLT1 in complex with a selective antagonist MK-D-046 and provide insights into hBLT1 l...

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Autores principales:	Nairie Michaelian, Anastasiia Sadybekov, Élie Besserer-Offroy, Gye Won Han, Harini Krishnamurthy, Beata A. Zamlynny, Xavier Fradera, Phieng Siliphaivanh, Jeremy Presland, Kerrie B. Spencer, Stephen M. Soisson, Petr Popov, Philippe Sarret, Vsevolod Katritch, Vadim Cherezov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/718b186632fa46f2ad43c9c7ad152fa9
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spelling	oai:doaj.org-article:718b186632fa46f2ad43c9c7ad152fa92021-12-02T16:51:34ZStructural insights on ligand recognition at the human leukotriene B4 receptor 110.1038/s41467-021-23149-12041-1723https://doaj.org/article/718b186632fa46f2ad43c9c7ad152fa92021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23149-1https://doaj.org/toc/2041-1723Human leukotriene B4 receptors (BLT1 and BLT2) are members of the GPCR superfamily that respond to a potent pro-inflammatory lipid and chemoattractant LTB4. Here authors determined a crystal structure of the human BLT1 in complex with a selective antagonist MK-D-046 and provide insights into hBLT1 ligand recognition and its mechanism of action.Nairie MichaelianAnastasiia SadybekovÉlie Besserer-OffroyGye Won HanHarini KrishnamurthyBeata A. ZamlynnyXavier FraderaPhieng SiliphaivanhJeremy PreslandKerrie B. SpencerStephen M. SoissonPetr PopovPhilippe SarretVsevolod KatritchVadim CherezovNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nairie Michaelian Anastasiia Sadybekov Élie Besserer-Offroy Gye Won Han Harini Krishnamurthy Beata A. Zamlynny Xavier Fradera Phieng Siliphaivanh Jeremy Presland Kerrie B. Spencer Stephen M. Soisson Petr Popov Philippe Sarret Vsevolod Katritch Vadim Cherezov Structural insights on ligand recognition at the human leukotriene B4 receptor 1
description	Human leukotriene B4 receptors (BLT1 and BLT2) are members of the GPCR superfamily that respond to a potent pro-inflammatory lipid and chemoattractant LTB4. Here authors determined a crystal structure of the human BLT1 in complex with a selective antagonist MK-D-046 and provide insights into hBLT1 ligand recognition and its mechanism of action.
format	article
author	Nairie Michaelian Anastasiia Sadybekov Élie Besserer-Offroy Gye Won Han Harini Krishnamurthy Beata A. Zamlynny Xavier Fradera Phieng Siliphaivanh Jeremy Presland Kerrie B. Spencer Stephen M. Soisson Petr Popov Philippe Sarret Vsevolod Katritch Vadim Cherezov
author_facet	Nairie Michaelian Anastasiia Sadybekov Élie Besserer-Offroy Gye Won Han Harini Krishnamurthy Beata A. Zamlynny Xavier Fradera Phieng Siliphaivanh Jeremy Presland Kerrie B. Spencer Stephen M. Soisson Petr Popov Philippe Sarret Vsevolod Katritch Vadim Cherezov
author_sort	Nairie Michaelian
title	Structural insights on ligand recognition at the human leukotriene B4 receptor 1
title_short	Structural insights on ligand recognition at the human leukotriene B4 receptor 1
title_full	Structural insights on ligand recognition at the human leukotriene B4 receptor 1
title_fullStr	Structural insights on ligand recognition at the human leukotriene B4 receptor 1
title_full_unstemmed	Structural insights on ligand recognition at the human leukotriene B4 receptor 1
title_sort	structural insights on ligand recognition at the human leukotriene b4 receptor 1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/718b186632fa46f2ad43c9c7ad152fa9
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Structural insights on ligand recognition at the human leukotriene B4 receptor 1

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