Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

Microglia and monocytes contribute to neuropathic pain states, but the precise role of the two cell types is not clear. Here Peng et al.use temporally controlled ablation of monocytes and microglia in mice to show that these cells work together to initiate neuropathic-pain like behaviour, but are le...

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Autores principales:	Jiyun Peng, Nan Gu, Lijun Zhou, Ukpong B Eyo, Madhuvika Murugan, Wen-Biao Gan, Long-Jun Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/718c07a2fe284ea1b1b6c6e085269f46
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spelling	oai:doaj.org-article:718c07a2fe284ea1b1b6c6e085269f462021-12-02T15:34:09ZMicroglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury10.1038/ncomms120292041-1723https://doaj.org/article/718c07a2fe284ea1b1b6c6e085269f462016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12029https://doaj.org/toc/2041-1723Microglia and monocytes contribute to neuropathic pain states, but the precise role of the two cell types is not clear. Here Peng et al.use temporally controlled ablation of monocytes and microglia in mice to show that these cells work together to initiate neuropathic-pain like behaviour, but are less important in the maintenance phase.Jiyun PengNan GuLijun ZhouUkpong B EyoMadhuvika MuruganWen-Biao GanLong-Jun WuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiyun Peng Nan Gu Lijun Zhou Ukpong B Eyo Madhuvika Murugan Wen-Biao Gan Long-Jun Wu Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury
description	Microglia and monocytes contribute to neuropathic pain states, but the precise role of the two cell types is not clear. Here Peng et al.use temporally controlled ablation of monocytes and microglia in mice to show that these cells work together to initiate neuropathic-pain like behaviour, but are less important in the maintenance phase.
format	article
author	Jiyun Peng Nan Gu Lijun Zhou Ukpong B Eyo Madhuvika Murugan Wen-Biao Gan Long-Jun Wu
author_facet	Jiyun Peng Nan Gu Lijun Zhou Ukpong B Eyo Madhuvika Murugan Wen-Biao Gan Long-Jun Wu
author_sort	Jiyun Peng
title	Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury
title_short	Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury
title_full	Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury
title_fullStr	Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury
title_full_unstemmed	Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury
title_sort	microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/718c07a2fe284ea1b1b6c6e085269f46
work_keys_str_mv	AT jiyunpeng microgliaandmonocytessynergisticallypromotethetransitionfromacutetochronicpainafternerveinjury AT nangu microgliaandmonocytessynergisticallypromotethetransitionfromacutetochronicpainafternerveinjury AT lijunzhou microgliaandmonocytessynergisticallypromotethetransitionfromacutetochronicpainafternerveinjury AT ukpongbeyo microgliaandmonocytessynergisticallypromotethetransitionfromacutetochronicpainafternerveinjury AT madhuvikamurugan microgliaandmonocytessynergisticallypromotethetransitionfromacutetochronicpainafternerveinjury AT wenbiaogan microgliaandmonocytessynergisticallypromotethetransitionfromacutetochronicpainafternerveinjury AT longjunwu microgliaandmonocytessynergisticallypromotethetransitionfromacutetochronicpainafternerveinjury
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Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

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