Population Structure and Genetic Diversity among Isolates of <italic toggle="yes">Coccidioides posadasii</italic> in Venezuela and Surrounding Regions

ABSTRACT Coccidioides posadasii is a pathogenic fungus that causes coccidioidomycosis in many arid regions of the Americas. One of these regions is bordered by the Caribbean Sea, and the surrounding landscape may play an important role in the dispersion of C. posadasii across South America through s...

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Autores principales:	Marcus M. Teixeira, Primavera Alvarado, Chandler C. Roe, George R. Thompson, José S. L. Patané, Jason W. Sahl, Paul Keim, John N. Galgiani, Anastasia P. Litvintseva, Daniel R. Matute, Bridget M. Barker
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	coccidioidomycosis Venezuela Coccidioides posadasii Caribbean Valley Fever Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/718ff3fe99bc4a2e9bf601f6b4f033fe
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spelling	oai:doaj.org-article:718ff3fe99bc4a2e9bf601f6b4f033fe2021-11-15T15:54:47ZPopulation Structure and Genetic Diversity among Isolates of <italic toggle="yes">Coccidioides posadasii</italic> in Venezuela and Surrounding Regions10.1128/mBio.01976-192150-7511https://doaj.org/article/718ff3fe99bc4a2e9bf601f6b4f033fe2019-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01976-19https://doaj.org/toc/2150-7511ABSTRACT Coccidioides posadasii is a pathogenic fungus that causes coccidioidomycosis in many arid regions of the Americas. One of these regions is bordered by the Caribbean Sea, and the surrounding landscape may play an important role in the dispersion of C. posadasii across South America through southeastern Mexico, Honduras, Guatemala, and Venezuela. Comparative phylogenomic analyses of C. posadasii reveal that clinical strains from Venezuela are genetically distinct from the North American populations found in (i) Arizona and (ii) Texas, Mexico, and the rest of South America (TX/MX/SA). We find evidence for admixture between the Venezuela and the North American populations of C. posadasii in Central America. Additionally, the proportion of Venezuelan alleles in the admixed population decreases as latitude (and distance from Venezuela) increases. Our results indicate that the population in Venezuela may have been subjected to a recent bottleneck and shows a strong population structure. This analysis provides insight into potential for Coccidioides spp. to invade new regions. IMPORTANCE Valley Fever is a fungal disease caused by two species of fungi: Coccidioides immitis and C. posadasii. These fungi are found throughout the arid regions of North and South America; however, our understanding of genetic diversity and disease in South America is limited. In this report, we analyze 10 new genomes of Coccidioides posadasii from regions bordering the Caribbean Sea. We show that these populations are distinct and that isolates from Venezuela are likely a result of a recent bottleneck. These data point to patterns that might be observed when investigating recently established populations.Marcus M. TeixeiraPrimavera AlvaradoChandler C. RoeGeorge R. ThompsonJosé S. L. PatanéJason W. SahlPaul KeimJohn N. GalgianiAnastasia P. LitvintsevaDaniel R. MatuteBridget M. BarkerAmerican Society for MicrobiologyarticlecoccidioidomycosisVenezuelaCoccidioides posadasiiCaribbeanValley FeverMicrobiologyQR1-502ENmBio, Vol 10, Iss 6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	coccidioidomycosis Venezuela Coccidioides posadasii Caribbean Valley Fever Microbiology QR1-502
spellingShingle	coccidioidomycosis Venezuela Coccidioides posadasii Caribbean Valley Fever Microbiology QR1-502 Marcus M. Teixeira Primavera Alvarado Chandler C. Roe George R. Thompson José S. L. Patané Jason W. Sahl Paul Keim John N. Galgiani Anastasia P. Litvintseva Daniel R. Matute Bridget M. Barker Population Structure and Genetic Diversity among Isolates of <italic toggle="yes">Coccidioides posadasii</italic> in Venezuela and Surrounding Regions
description	ABSTRACT Coccidioides posadasii is a pathogenic fungus that causes coccidioidomycosis in many arid regions of the Americas. One of these regions is bordered by the Caribbean Sea, and the surrounding landscape may play an important role in the dispersion of C. posadasii across South America through southeastern Mexico, Honduras, Guatemala, and Venezuela. Comparative phylogenomic analyses of C. posadasii reveal that clinical strains from Venezuela are genetically distinct from the North American populations found in (i) Arizona and (ii) Texas, Mexico, and the rest of South America (TX/MX/SA). We find evidence for admixture between the Venezuela and the North American populations of C. posadasii in Central America. Additionally, the proportion of Venezuelan alleles in the admixed population decreases as latitude (and distance from Venezuela) increases. Our results indicate that the population in Venezuela may have been subjected to a recent bottleneck and shows a strong population structure. This analysis provides insight into potential for Coccidioides spp. to invade new regions. IMPORTANCE Valley Fever is a fungal disease caused by two species of fungi: Coccidioides immitis and C. posadasii. These fungi are found throughout the arid regions of North and South America; however, our understanding of genetic diversity and disease in South America is limited. In this report, we analyze 10 new genomes of Coccidioides posadasii from regions bordering the Caribbean Sea. We show that these populations are distinct and that isolates from Venezuela are likely a result of a recent bottleneck. These data point to patterns that might be observed when investigating recently established populations.
format	article
author	Marcus M. Teixeira Primavera Alvarado Chandler C. Roe George R. Thompson José S. L. Patané Jason W. Sahl Paul Keim John N. Galgiani Anastasia P. Litvintseva Daniel R. Matute Bridget M. Barker
author_facet	Marcus M. Teixeira Primavera Alvarado Chandler C. Roe George R. Thompson José S. L. Patané Jason W. Sahl Paul Keim John N. Galgiani Anastasia P. Litvintseva Daniel R. Matute Bridget M. Barker
author_sort	Marcus M. Teixeira
title	Population Structure and Genetic Diversity among Isolates of <italic toggle="yes">Coccidioides posadasii</italic> in Venezuela and Surrounding Regions
title_short	Population Structure and Genetic Diversity among Isolates of <italic toggle="yes">Coccidioides posadasii</italic> in Venezuela and Surrounding Regions
title_full	Population Structure and Genetic Diversity among Isolates of <italic toggle="yes">Coccidioides posadasii</italic> in Venezuela and Surrounding Regions
title_fullStr	Population Structure and Genetic Diversity among Isolates of <italic toggle="yes">Coccidioides posadasii</italic> in Venezuela and Surrounding Regions
title_full_unstemmed	Population Structure and Genetic Diversity among Isolates of <italic toggle="yes">Coccidioides posadasii</italic> in Venezuela and Surrounding Regions
title_sort	population structure and genetic diversity among isolates of <italic toggle="yes">coccidioides posadasii</italic> in venezuela and surrounding regions
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/718ff3fe99bc4a2e9bf601f6b4f033fe
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Population Structure and Genetic Diversity among Isolates of <italic toggle="yes">Coccidioides posadasii</italic> in Venezuela and Surrounding Regions

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