Nanoparticles in relation to peptide and protein aggregation

Masihuz Zaman, Ejaz Ahmad, Atiyatul Qadeer, Gulam Rabbani, Rizwan Hasan Khan Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India Abstract: Over the past two decades, there has been considerable research interest in the use of nanoparticles in the study of protein and pe...

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Autores principales:	Zaman M, Ahmad E, Qadeer A, Rabbani G, Khan RH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/71912f14540c4c80912e3e031bbd8250
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spelling	oai:doaj.org-article:71912f14540c4c80912e3e031bbd82502021-12-02T02:16:49ZNanoparticles in relation to peptide and protein aggregation1178-2013https://doaj.org/article/71912f14540c4c80912e3e031bbd82502014-02-01T00:00:00Zhttp://www.dovepress.com/nanoparticles-in-relation-to-peptide-and-protein-aggregation-a15786https://doaj.org/toc/1178-2013 Masihuz Zaman, Ejaz Ahmad, Atiyatul Qadeer, Gulam Rabbani, Rizwan Hasan Khan Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India Abstract: Over the past two decades, there has been considerable research interest in the use of nanoparticles in the study of protein and peptide aggregation, and of amyloid-related diseases. The influence of nanoparticles on amyloid formation yields great interest due to its small size and high surface area-to-volume ratio. Targeting nucleation kinetics by nanoparticles is one of the most searched for ways to control or induce this phenomenon. The observed effect of nanoparticles on the nucleation phase is determined by particle composition, as well as the amount and nature of the particle's surface. Various thermodynamic parameters influence the interaction of proteins and nanoparticles in the solution, and regulate the protein assembly into fibrils, as well as the disaggregation of preformed fibrils. Metals, organic particles, inorganic particles, amino acids, peptides, proteins, and so on are more suitable candidates for nanoparticle formulation. In the present review, we attempt to explore the effects of nanoparticles on protein and peptide fibrillation processes from both perspectives (ie, as inducers and inhibitors on nucleation kinetics and in the disaggregation of preformed fibrils). Their formulation and characterization by different techniques have been also addressed, along with their toxicological effects, both in vivo and in vitro. Keywords: amyloid formation, inducer, inhibitor, nanoparticle, nucleation, toxicityZaman MAhmad EQadeer ARabbani GKhan RHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 899-912 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zaman M Ahmad E Qadeer A Rabbani G Khan RH Nanoparticles in relation to peptide and protein aggregation
description	Masihuz Zaman, Ejaz Ahmad, Atiyatul Qadeer, Gulam Rabbani, Rizwan Hasan Khan Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India Abstract: Over the past two decades, there has been considerable research interest in the use of nanoparticles in the study of protein and peptide aggregation, and of amyloid-related diseases. The influence of nanoparticles on amyloid formation yields great interest due to its small size and high surface area-to-volume ratio. Targeting nucleation kinetics by nanoparticles is one of the most searched for ways to control or induce this phenomenon. The observed effect of nanoparticles on the nucleation phase is determined by particle composition, as well as the amount and nature of the particle's surface. Various thermodynamic parameters influence the interaction of proteins and nanoparticles in the solution, and regulate the protein assembly into fibrils, as well as the disaggregation of preformed fibrils. Metals, organic particles, inorganic particles, amino acids, peptides, proteins, and so on are more suitable candidates for nanoparticle formulation. In the present review, we attempt to explore the effects of nanoparticles on protein and peptide fibrillation processes from both perspectives (ie, as inducers and inhibitors on nucleation kinetics and in the disaggregation of preformed fibrils). Their formulation and characterization by different techniques have been also addressed, along with their toxicological effects, both in vivo and in vitro. Keywords: amyloid formation, inducer, inhibitor, nanoparticle, nucleation, toxicity
format	article
author	Zaman M Ahmad E Qadeer A Rabbani G Khan RH
author_facet	Zaman M Ahmad E Qadeer A Rabbani G Khan RH
author_sort	Zaman M
title	Nanoparticles in relation to peptide and protein aggregation
title_short	Nanoparticles in relation to peptide and protein aggregation
title_full	Nanoparticles in relation to peptide and protein aggregation
title_fullStr	Nanoparticles in relation to peptide and protein aggregation
title_full_unstemmed	Nanoparticles in relation to peptide and protein aggregation
title_sort	nanoparticles in relation to peptide and protein aggregation
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/71912f14540c4c80912e3e031bbd8250
work_keys_str_mv	AT zamanm nanoparticlesinrelationtopeptideandproteinaggregation AT ahmade nanoparticlesinrelationtopeptideandproteinaggregation AT qadeera nanoparticlesinrelationtopeptideandproteinaggregation AT rabbanig nanoparticlesinrelationtopeptideandproteinaggregation AT khanrh nanoparticlesinrelationtopeptideandproteinaggregation
_version_	1718402602706665472

Nanoparticles in relation to peptide and protein aggregation

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