Cytokine-induced memory-like natural killer cells for cancer immunotherapy

Abstract Natural killer cells are an important part of the innate immune system mediating robust responses to virus-infected and malignant cells without needing prior antigen priming. NK cells have always been thought to be short-lived and with no antigen specificity; however, recent data support th...

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Autores principales:	Mubin Tarannum, Rizwan Romee
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Natural killer cells Cytokine-induced memory-like NK cells Innate memory Cancer immunotherapy Adoptive cell therapy Medicine (General) R5-920 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/71996d026732453292130b7c623ad196
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spelling	oai:doaj.org-article:71996d026732453292130b7c623ad1962021-12-05T12:05:41ZCytokine-induced memory-like natural killer cells for cancer immunotherapy10.1186/s13287-021-02655-51757-6512https://doaj.org/article/71996d026732453292130b7c623ad1962021-12-01T00:00:00Zhttps://doi.org/10.1186/s13287-021-02655-5https://doaj.org/toc/1757-6512Abstract Natural killer cells are an important part of the innate immune system mediating robust responses to virus-infected and malignant cells without needing prior antigen priming. NK cells have always been thought to be short-lived and with no antigen specificity; however, recent data support the presence of NK cell memory including in the hapten-specific contact hypersensitivity model and in certain viral infections. The memory-like features can also be generated by short-term activation of both murine and human NK cells with cytokine combination of IL-12, IL-15 and IL-18, imparting increased longevity and enhanced anticancer functionality. Preclinical studies and very early clinical trials demonstrate safety and very promising clinical activity of these cytokine-induced memory-like (CIML) NK cells, making them an attractive cell type for developing novel adoptive cellular immunotherapy strategies. Furthermore, efforts are on to arm them with novel gene constructs for enhanced tumor targeting and function.Mubin TarannumRizwan RomeeBMCarticleNatural killer cellsCytokine-induced memory-like NK cellsInnate memoryCancer immunotherapyAdoptive cell therapyMedicine (General)R5-920BiochemistryQD415-436ENStem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Natural killer cells Cytokine-induced memory-like NK cells Innate memory Cancer immunotherapy Adoptive cell therapy Medicine (General) R5-920 Biochemistry QD415-436
spellingShingle	Natural killer cells Cytokine-induced memory-like NK cells Innate memory Cancer immunotherapy Adoptive cell therapy Medicine (General) R5-920 Biochemistry QD415-436 Mubin Tarannum Rizwan Romee Cytokine-induced memory-like natural killer cells for cancer immunotherapy
description	Abstract Natural killer cells are an important part of the innate immune system mediating robust responses to virus-infected and malignant cells without needing prior antigen priming. NK cells have always been thought to be short-lived and with no antigen specificity; however, recent data support the presence of NK cell memory including in the hapten-specific contact hypersensitivity model and in certain viral infections. The memory-like features can also be generated by short-term activation of both murine and human NK cells with cytokine combination of IL-12, IL-15 and IL-18, imparting increased longevity and enhanced anticancer functionality. Preclinical studies and very early clinical trials demonstrate safety and very promising clinical activity of these cytokine-induced memory-like (CIML) NK cells, making them an attractive cell type for developing novel adoptive cellular immunotherapy strategies. Furthermore, efforts are on to arm them with novel gene constructs for enhanced tumor targeting and function.
format	article
author	Mubin Tarannum Rizwan Romee
author_facet	Mubin Tarannum Rizwan Romee
author_sort	Mubin Tarannum
title	Cytokine-induced memory-like natural killer cells for cancer immunotherapy
title_short	Cytokine-induced memory-like natural killer cells for cancer immunotherapy
title_full	Cytokine-induced memory-like natural killer cells for cancer immunotherapy
title_fullStr	Cytokine-induced memory-like natural killer cells for cancer immunotherapy
title_full_unstemmed	Cytokine-induced memory-like natural killer cells for cancer immunotherapy
title_sort	cytokine-induced memory-like natural killer cells for cancer immunotherapy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/71996d026732453292130b7c623ad196
work_keys_str_mv	AT mubintarannum cytokineinducedmemorylikenaturalkillercellsforcancerimmunotherapy AT rizwanromee cytokineinducedmemorylikenaturalkillercellsforcancerimmunotherapy
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Cytokine-induced memory-like natural killer cells for cancer immunotherapy

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