Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn’s disease complicated with inflammatory mass

Abstract The ancient Chinese medical literature, as well as our prior clinical experience, suggests that fecal microbiota transplantation (FMT) could treat the inflammatory mass. We aimed to evaluate the efficacy and safety of multiple fresh FMTs for Crohn’s disease (CD) complicated with intraabdomi...

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Autores principales: Zhi He, Pan Li, Jianguo Zhu, Bota Cui, Lijuan Xu, Jie Xiang, Ting Zhang, Chuyan Long, Guangming Huang, Guozhong Ji, Yongzhan Nie, Kaichun Wu, Daiming Fan, Faming Zhang
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/719bee55394f45ccb1b0d332a4959ad8
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spelling oai:doaj.org-article:719bee55394f45ccb1b0d332a4959ad82021-12-02T16:06:56ZMultiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn’s disease complicated with inflammatory mass10.1038/s41598-017-04984-z2045-2322https://doaj.org/article/719bee55394f45ccb1b0d332a4959ad82017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04984-zhttps://doaj.org/toc/2045-2322Abstract The ancient Chinese medical literature, as well as our prior clinical experience, suggests that fecal microbiota transplantation (FMT) could treat the inflammatory mass. We aimed to evaluate the efficacy and safety of multiple fresh FMTs for Crohn’s disease (CD) complicated with intraabdominal inflammatory mass. The "one-hour FMT protocol" was followed in all patients. Twenty-five patients were diagnosed with CD and related inflammatory mass by CT or MRI. All patients received the initial FMT followed by repeated FMTs every 3 months. The primary endpoint was clinical response (improvement and remission) and sustained clinical remission at 12 months. Secondary endpoints were improvement in size of phegmon/abscess based upon cross-sectional imaging and safety of FMT. 68.0% (17/25) and 52.0% (13/25) of patients achieved clinical response and clinical remission at 3 months post the initial FMT, respectively. The proportion of patients at 6 months, 12 months and 18 months achieving sustained clinical remission with sequential FMTs was 48.0% (12/25), 32.0% (8/25) and 22.7% (5/22), respectively. 9.5% (2/21) of patients achieved radiological healing and 71.4% (15/21) achieved radiological improvement. No severe adverse events related to FMT were observed. This pragmatic study suggested that sequential fresh FMTs might be a promising, safe and effective therapy to induce and maintain clinical remission in CD with intraabdominal inflammatory mass.Zhi HePan LiJianguo ZhuBota CuiLijuan XuJie XiangTing ZhangChuyan LongGuangming HuangGuozhong JiYongzhan NieKaichun WuDaiming FanFaming ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Zhi He
Pan Li
Jianguo Zhu
Bota Cui
Lijuan Xu
Jie Xiang
Ting Zhang
Chuyan Long
Guangming Huang
Guozhong Ji
Yongzhan Nie
Kaichun Wu
Daiming Fan
Faming Zhang
Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn’s disease complicated with inflammatory mass
description Abstract The ancient Chinese medical literature, as well as our prior clinical experience, suggests that fecal microbiota transplantation (FMT) could treat the inflammatory mass. We aimed to evaluate the efficacy and safety of multiple fresh FMTs for Crohn’s disease (CD) complicated with intraabdominal inflammatory mass. The "one-hour FMT protocol" was followed in all patients. Twenty-five patients were diagnosed with CD and related inflammatory mass by CT or MRI. All patients received the initial FMT followed by repeated FMTs every 3 months. The primary endpoint was clinical response (improvement and remission) and sustained clinical remission at 12 months. Secondary endpoints were improvement in size of phegmon/abscess based upon cross-sectional imaging and safety of FMT. 68.0% (17/25) and 52.0% (13/25) of patients achieved clinical response and clinical remission at 3 months post the initial FMT, respectively. The proportion of patients at 6 months, 12 months and 18 months achieving sustained clinical remission with sequential FMTs was 48.0% (12/25), 32.0% (8/25) and 22.7% (5/22), respectively. 9.5% (2/21) of patients achieved radiological healing and 71.4% (15/21) achieved radiological improvement. No severe adverse events related to FMT were observed. This pragmatic study suggested that sequential fresh FMTs might be a promising, safe and effective therapy to induce and maintain clinical remission in CD with intraabdominal inflammatory mass.
format article
author Zhi He
Pan Li
Jianguo Zhu
Bota Cui
Lijuan Xu
Jie Xiang
Ting Zhang
Chuyan Long
Guangming Huang
Guozhong Ji
Yongzhan Nie
Kaichun Wu
Daiming Fan
Faming Zhang
author_facet Zhi He
Pan Li
Jianguo Zhu
Bota Cui
Lijuan Xu
Jie Xiang
Ting Zhang
Chuyan Long
Guangming Huang
Guozhong Ji
Yongzhan Nie
Kaichun Wu
Daiming Fan
Faming Zhang
author_sort Zhi He
title Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn’s disease complicated with inflammatory mass
title_short Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn’s disease complicated with inflammatory mass
title_full Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn’s disease complicated with inflammatory mass
title_fullStr Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn’s disease complicated with inflammatory mass
title_full_unstemmed Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn’s disease complicated with inflammatory mass
title_sort multiple fresh fecal microbiota transplants induces and maintains clinical remission in crohn’s disease complicated with inflammatory mass
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/719bee55394f45ccb1b0d332a4959ad8
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