Heart Mitochondrial Metabolic Flexibility and Redox Status Are Improved by Donkey and Human Milk Intake

The biological mechanisms linking nutrition and antioxidants content of the diet with cardiovascular protection are subject of intense investigation. It has been demonstrated that dietary supplementation with cow, donkey or human milk, characterized by distinct nutritional properties, triggers signi...

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Autores principales:	Giovanna Trinchese, Fabiano Cimmino, Gina Cavaliere, Luigi Rosati, Angela Catapano, Daniela Sorriento, Elisabetta Murru, Luca Bernardo, Luciana Pagani, Paolo Bergamo, Rosaria Scudiero, Guido Iaccarino, Luigi Greco, Sebastiano Banni, Marianna Crispino, Maria Pina Mollica
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	heart mitochondria oxidative stress nutrition milk antioxidants fatty acids Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/71a2817f702147f68afc55f65cd8595e
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spelling	oai:doaj.org-article:71a2817f702147f68afc55f65cd8595e2021-11-25T16:28:52ZHeart Mitochondrial Metabolic Flexibility and Redox Status Are Improved by Donkey and Human Milk Intake10.3390/antiox101118072076-3921https://doaj.org/article/71a2817f702147f68afc55f65cd8595e2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1807https://doaj.org/toc/2076-3921The biological mechanisms linking nutrition and antioxidants content of the diet with cardiovascular protection are subject of intense investigation. It has been demonstrated that dietary supplementation with cow, donkey or human milk, characterized by distinct nutritional properties, triggers significant differences in the metabolic and inflammatory status through the modulation of hepatic and skeletal muscle mitochondrial functions. Cardiac mitochondria play a key role for energy-demanding heart functions, and their disfunctions is leading to pathologies. Indeed, an altered heart mitochondrial function and the consequent increased reactive oxygen species (ROS) production and inflammatory state, is linked to several cardiac diseases such as hypertension and heart failure. In this work it was investigated the impact of the milk consumption on heart mitochondrial functions, inflammation and oxidative stress. In addition, it was underlined the crosstalk between mitochondrial metabolic flexibility, lipid storage and redox status as control mechanisms for the maintenance of cardiovascular health.Giovanna TrincheseFabiano CimminoGina CavaliereLuigi RosatiAngela CatapanoDaniela SorrientoElisabetta MurruLuca BernardoLuciana PaganiPaolo BergamoRosaria ScudieroGuido IaccarinoLuigi GrecoSebastiano BanniMarianna CrispinoMaria Pina MollicaMDPI AGarticleheart mitochondriaoxidative stressnutritionmilkantioxidantsfatty acidsTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1807, p 1807 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart mitochondria oxidative stress nutrition milk antioxidants fatty acids Therapeutics. Pharmacology RM1-950
spellingShingle	heart mitochondria oxidative stress nutrition milk antioxidants fatty acids Therapeutics. Pharmacology RM1-950 Giovanna Trinchese Fabiano Cimmino Gina Cavaliere Luigi Rosati Angela Catapano Daniela Sorriento Elisabetta Murru Luca Bernardo Luciana Pagani Paolo Bergamo Rosaria Scudiero Guido Iaccarino Luigi Greco Sebastiano Banni Marianna Crispino Maria Pina Mollica Heart Mitochondrial Metabolic Flexibility and Redox Status Are Improved by Donkey and Human Milk Intake
description	The biological mechanisms linking nutrition and antioxidants content of the diet with cardiovascular protection are subject of intense investigation. It has been demonstrated that dietary supplementation with cow, donkey or human milk, characterized by distinct nutritional properties, triggers significant differences in the metabolic and inflammatory status through the modulation of hepatic and skeletal muscle mitochondrial functions. Cardiac mitochondria play a key role for energy-demanding heart functions, and their disfunctions is leading to pathologies. Indeed, an altered heart mitochondrial function and the consequent increased reactive oxygen species (ROS) production and inflammatory state, is linked to several cardiac diseases such as hypertension and heart failure. In this work it was investigated the impact of the milk consumption on heart mitochondrial functions, inflammation and oxidative stress. In addition, it was underlined the crosstalk between mitochondrial metabolic flexibility, lipid storage and redox status as control mechanisms for the maintenance of cardiovascular health.
format	article
author	Giovanna Trinchese Fabiano Cimmino Gina Cavaliere Luigi Rosati Angela Catapano Daniela Sorriento Elisabetta Murru Luca Bernardo Luciana Pagani Paolo Bergamo Rosaria Scudiero Guido Iaccarino Luigi Greco Sebastiano Banni Marianna Crispino Maria Pina Mollica
author_facet	Giovanna Trinchese Fabiano Cimmino Gina Cavaliere Luigi Rosati Angela Catapano Daniela Sorriento Elisabetta Murru Luca Bernardo Luciana Pagani Paolo Bergamo Rosaria Scudiero Guido Iaccarino Luigi Greco Sebastiano Banni Marianna Crispino Maria Pina Mollica
author_sort	Giovanna Trinchese
title	Heart Mitochondrial Metabolic Flexibility and Redox Status Are Improved by Donkey and Human Milk Intake
title_short	Heart Mitochondrial Metabolic Flexibility and Redox Status Are Improved by Donkey and Human Milk Intake
title_full	Heart Mitochondrial Metabolic Flexibility and Redox Status Are Improved by Donkey and Human Milk Intake
title_fullStr	Heart Mitochondrial Metabolic Flexibility and Redox Status Are Improved by Donkey and Human Milk Intake
title_full_unstemmed	Heart Mitochondrial Metabolic Flexibility and Redox Status Are Improved by Donkey and Human Milk Intake
title_sort	heart mitochondrial metabolic flexibility and redox status are improved by donkey and human milk intake
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/71a2817f702147f68afc55f65cd8595e
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Heart Mitochondrial Metabolic Flexibility and Redox Status Are Improved by Donkey and Human Milk Intake

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