Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis

Abstract Non-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting a young population as the peak age of diagnosis is in the 40 s. The natural history of non-traumatic ON leads to a collapse of the femoral head requiring prosthetic replacement in a 60% of cases. Although tra...

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Autores principales:	Tristan Pascart, Guillaume Falgayrac, Henri Migaud, Jean-François Quinchon, Laurène Norberciak, Jean-François Budzik, Julien Paccou, Anne Cotten, Guillaume Penel, Bernard Cortet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/71a3a27a1c074b2ca2c32071d840997f
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spelling	oai:doaj.org-article:71a3a27a1c074b2ca2c32071d840997f2021-12-02T15:06:11ZRegion specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis10.1038/s41598-017-00162-32045-2322https://doaj.org/article/71a3a27a1c074b2ca2c32071d840997f2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00162-3https://doaj.org/toc/2045-2322Abstract Non-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting a young population as the peak age of diagnosis is in the 40 s. The natural history of non-traumatic ON leads to a collapse of the femoral head requiring prosthetic replacement in a 60% of cases. Although trabecular bone involvement in the collapse is suspected, the underlying modifications induced at a molecular level have not been explored in humans. Here, we examine changes in the molecular composition and structure of bone as evaluated by Raman spectroscopy in human end-stage ON. Comparing samples from femoral heads harvested from 11 patients and 11 cadaveric controls, we show that the mineral and organic chemical composition of trabecular bone in ON is not modified apart from age-related differences. We also show that the molecular composition in the necrotic part of the femoral head is not different from the composition of the remaining ‘healthy’ trabecular bone of the femoral head. These findings support that quality of trabecular bone is not modified during ON despite extensive bone marrow necrosis and osteocyte death observed even in the ‘healthy’ zones on histological examination.Tristan PascartGuillaume FalgayracHenri MigaudJean-François QuinchonLaurène NorberciakJean-François BudzikJulien PaccouAnne CottenGuillaume PenelBernard CortetNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tristan Pascart Guillaume Falgayrac Henri Migaud Jean-François Quinchon Laurène Norberciak Jean-François Budzik Julien Paccou Anne Cotten Guillaume Penel Bernard Cortet Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis
description	Abstract Non-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting a young population as the peak age of diagnosis is in the 40 s. The natural history of non-traumatic ON leads to a collapse of the femoral head requiring prosthetic replacement in a 60% of cases. Although trabecular bone involvement in the collapse is suspected, the underlying modifications induced at a molecular level have not been explored in humans. Here, we examine changes in the molecular composition and structure of bone as evaluated by Raman spectroscopy in human end-stage ON. Comparing samples from femoral heads harvested from 11 patients and 11 cadaveric controls, we show that the mineral and organic chemical composition of trabecular bone in ON is not modified apart from age-related differences. We also show that the molecular composition in the necrotic part of the femoral head is not different from the composition of the remaining ‘healthy’ trabecular bone of the femoral head. These findings support that quality of trabecular bone is not modified during ON despite extensive bone marrow necrosis and osteocyte death observed even in the ‘healthy’ zones on histological examination.
format	article
author	Tristan Pascart Guillaume Falgayrac Henri Migaud Jean-François Quinchon Laurène Norberciak Jean-François Budzik Julien Paccou Anne Cotten Guillaume Penel Bernard Cortet
author_facet	Tristan Pascart Guillaume Falgayrac Henri Migaud Jean-François Quinchon Laurène Norberciak Jean-François Budzik Julien Paccou Anne Cotten Guillaume Penel Bernard Cortet
author_sort	Tristan Pascart
title	Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis
title_short	Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis
title_full	Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis
title_fullStr	Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis
title_full_unstemmed	Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis
title_sort	region specific raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/71a3a27a1c074b2ca2c32071d840997f
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Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis

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