HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients

Several human leukocyte antigen (HLA) alleles are strongly associated with susceptibility to classic Hodgkin lymphoma (cHL), also in subgroups stratified for presence of the Epstein–Barr virus (EBV). We tested the hypothesis that the pressure on cHL tumour cells to lose HLA expression is associated...

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Autores principales:	Geok Wee Tan, Peijia Jiang, Ilja M. Nolte, Kushi Kushekhar, Rianne N. Veenstra, Bouke G. Hepkema, Ruth F. Jarrett, Anke van den Berg, Arjan Diepstra
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cHL susceptibility HLA expression EBV Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/71a4121273e74fb4b2f653f84a47405b
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spelling	oai:doaj.org-article:71a4121273e74fb4b2f653f84a47405b2021-11-25T17:04:33ZHLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients10.3390/cancers132258332072-6694https://doaj.org/article/71a4121273e74fb4b2f653f84a47405b2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5833https://doaj.org/toc/2072-6694Several human leukocyte antigen (HLA) alleles are strongly associated with susceptibility to classic Hodgkin lymphoma (cHL), also in subgroups stratified for presence of the Epstein–Barr virus (EBV). We tested the hypothesis that the pressure on cHL tumour cells to lose HLA expression is associated with HLA susceptibility alleles. A meta-analysis was carried out to identify consistent protective and risk HLA alleles in a combined cohort of 839 cHL patients from the Netherlands and the United Kingdom. Tumour cell HLA expression was studied in 338 cHL cases from these two cohorts and correlated to the presence of specific susceptibility HLA alleles. Carriers of the HLA-DRB107 protective allele frequently lost HLA class II expression in cHL overall. Patients carrying the HLA-DRB115/16 (DR2) risk allele retained HLA class II expression in EBV− cHL and patients with the HLA-B*37 risk allele retained HLA class I expression more frequently than non-carriers in EBV+ cHL. The other susceptibility alleles showed no significant differences in expression. Thus, HLA expression by tumour cells is associated with a subset of the protective and risk alleles. This strongly suggests that HLA associations in cHL are related to peptide binding capacities of specific HLA alleles.Geok Wee TanPeijia JiangIlja M. NolteKushi KushekharRianne N. VeenstraBouke G. HepkemaRuth F. JarrettAnke van den BergArjan DiepstraMDPI AGarticlecHLsusceptibilityHLA expressionEBVNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5833, p 5833 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cHL susceptibility HLA expression EBV Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cHL susceptibility HLA expression EBV Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Geok Wee Tan Peijia Jiang Ilja M. Nolte Kushi Kushekhar Rianne N. Veenstra Bouke G. Hepkema Ruth F. Jarrett Anke van den Berg Arjan Diepstra HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients
description	Several human leukocyte antigen (HLA) alleles are strongly associated with susceptibility to classic Hodgkin lymphoma (cHL), also in subgroups stratified for presence of the Epstein–Barr virus (EBV). We tested the hypothesis that the pressure on cHL tumour cells to lose HLA expression is associated with HLA susceptibility alleles. A meta-analysis was carried out to identify consistent protective and risk HLA alleles in a combined cohort of 839 cHL patients from the Netherlands and the United Kingdom. Tumour cell HLA expression was studied in 338 cHL cases from these two cohorts and correlated to the presence of specific susceptibility HLA alleles. Carriers of the HLA-DRB107 protective allele frequently lost HLA class II expression in cHL overall. Patients carrying the HLA-DRB115/16 (DR2) risk allele retained HLA class II expression in EBV− cHL and patients with the HLA-B*37 risk allele retained HLA class I expression more frequently than non-carriers in EBV+ cHL. The other susceptibility alleles showed no significant differences in expression. Thus, HLA expression by tumour cells is associated with a subset of the protective and risk alleles. This strongly suggests that HLA associations in cHL are related to peptide binding capacities of specific HLA alleles.
format	article
author	Geok Wee Tan Peijia Jiang Ilja M. Nolte Kushi Kushekhar Rianne N. Veenstra Bouke G. Hepkema Ruth F. Jarrett Anke van den Berg Arjan Diepstra
author_facet	Geok Wee Tan Peijia Jiang Ilja M. Nolte Kushi Kushekhar Rianne N. Veenstra Bouke G. Hepkema Ruth F. Jarrett Anke van den Berg Arjan Diepstra
author_sort	Geok Wee Tan
title	HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients
title_short	HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients
title_full	HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients
title_fullStr	HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients
title_full_unstemmed	HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients
title_sort	hla expression in relation to hla type in classic hodgkin lymphoma patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/71a4121273e74fb4b2f653f84a47405b
work_keys_str_mv	AT geokweetan hlaexpressioninrelationtohlatypeinclassichodgkinlymphomapatients AT peijiajiang hlaexpressioninrelationtohlatypeinclassichodgkinlymphomapatients AT iljamnolte hlaexpressioninrelationtohlatypeinclassichodgkinlymphomapatients AT kushikushekhar hlaexpressioninrelationtohlatypeinclassichodgkinlymphomapatients AT riannenveenstra hlaexpressioninrelationtohlatypeinclassichodgkinlymphomapatients AT boukeghepkema hlaexpressioninrelationtohlatypeinclassichodgkinlymphomapatients AT ruthfjarrett hlaexpressioninrelationtohlatypeinclassichodgkinlymphomapatients AT ankevandenberg hlaexpressioninrelationtohlatypeinclassichodgkinlymphomapatients AT arjandiepstra hlaexpressioninrelationtohlatypeinclassichodgkinlymphomapatients
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HLA Expression in Relation to HLA Type in Classic Hodgkin Lymphoma Patients

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