Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.

Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.

<h4>Background</h4>Acute brain injury is an important health problem. Given the critical position of caspase 8 at the crossroads of cell death pathways, we generated a new viable mouse line (Ncasp8(-/-)), in which the gene encoding caspase 8 was selectively deleted in neurons by cre-lox...

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Main Authors: Maryla Krajewska, Zerong You, Juan Rong, Christina Kress, Xianshu Huang, Jinsheng Yang, Tiffany Kyoda, Ricardo Leyva, Steven Banares, Yue Hu, Chia-Hung Sze, Michael J Whalen, Leonardo Salmena, Razqallah Hakem, Brian P Head, John C Reed, Stan Krajewski
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/71a42f39eed444cdbeb7576dc1d2a7a9
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