Pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage

Abstract The Pax3/7 transcription factor family is integral to developmental gene networks contributing to important innovations in vertebrate evolution, including the neural crest. The basal chordate lineage of amphioxus is ideally placed to understand the dynamics of the gene regulatory network ev...

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Autores principales:	Thomas B. Barton-Owen, David E. K. Ferrier, Ildikó M. L. Somorjai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/71a4a307f33d415a986c54854f9a8ccf
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spelling	oai:doaj.org-article:71a4a307f33d415a986c54854f9a8ccf2021-12-02T15:08:10ZPax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage10.1038/s41598-018-27700-x2045-2322https://doaj.org/article/71a4a307f33d415a986c54854f9a8ccf2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-27700-xhttps://doaj.org/toc/2045-2322Abstract The Pax3/7 transcription factor family is integral to developmental gene networks contributing to important innovations in vertebrate evolution, including the neural crest. The basal chordate lineage of amphioxus is ideally placed to understand the dynamics of the gene regulatory network evolution that produced these novelties. We report here the discovery that the cephalochordate lineage possesses two Pax3/7 genes, Pax3/7a and Pax3/7b. The tandem duplication is ancestral to all extant amphioxus, occurring in both Asymmetron and Branchiostoma, but originated after the split from the lineage leading to vertebrates. The two paralogues are differentially expressed during embryonic development, particularly in neural and somitic tissues, suggesting distinct regulation. Our results have implications for the study of amphioxus regeneration, neural plate and crest evolution, and differential tandem paralogue evolution.Thomas B. Barton-OwenDavid E. K. FerrierIldikó M. L. SomorjaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas B. Barton-Owen David E. K. Ferrier Ildikó M. L. Somorjai Pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage
description	Abstract The Pax3/7 transcription factor family is integral to developmental gene networks contributing to important innovations in vertebrate evolution, including the neural crest. The basal chordate lineage of amphioxus is ideally placed to understand the dynamics of the gene regulatory network evolution that produced these novelties. We report here the discovery that the cephalochordate lineage possesses two Pax3/7 genes, Pax3/7a and Pax3/7b. The tandem duplication is ancestral to all extant amphioxus, occurring in both Asymmetron and Branchiostoma, but originated after the split from the lineage leading to vertebrates. The two paralogues are differentially expressed during embryonic development, particularly in neural and somitic tissues, suggesting distinct regulation. Our results have implications for the study of amphioxus regeneration, neural plate and crest evolution, and differential tandem paralogue evolution.
format	article
author	Thomas B. Barton-Owen David E. K. Ferrier Ildikó M. L. Somorjai
author_facet	Thomas B. Barton-Owen David E. K. Ferrier Ildikó M. L. Somorjai
author_sort	Thomas B. Barton-Owen
title	Pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage
title_short	Pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage
title_full	Pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage
title_fullStr	Pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage
title_full_unstemmed	Pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage
title_sort	pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/71a4a307f33d415a986c54854f9a8ccf
work_keys_str_mv	AT thomasbbartonowen pax37duplicatedanddivergedindependentlyinamphioxusthebasalchordatelineage AT davidekferrier pax37duplicatedanddivergedindependentlyinamphioxusthebasalchordatelineage AT ildikomlsomorjai pax37duplicatedanddivergedindependentlyinamphioxusthebasalchordatelineage
_version_	1718388258583347200

Pax3/7 duplicated and diverged independently in amphioxus, the basal chordate lineage

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