Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection

Chronic hepatitis B virus (CHB) infection remains a major global public health issue for which there is still lacking effective curative treatment. Interferon-α (IFN-α) and its pegylated form have been approved as an anti-HBV drug with the advantage of antiviral activity and host immunity against HB...

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Autores principales:	Jiayi Wang, Lingyao Du, Hong Tang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	chronic hepatitis B interferon-α negative regulators host factors non-response Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/71acc532ea334bc291e7c65f66355067
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spelling	oai:doaj.org-article:71acc532ea334bc291e7c65f663550672021-11-30T16:34:35ZSuppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection2296-858X10.3389/fmed.2021.784172https://doaj.org/article/71acc532ea334bc291e7c65f663550672021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.784172/fullhttps://doaj.org/toc/2296-858XChronic hepatitis B virus (CHB) infection remains a major global public health issue for which there is still lacking effective curative treatment. Interferon-α (IFN-α) and its pegylated form have been approved as an anti-HBV drug with the advantage of antiviral activity and host immunity against HBV infection enhancement, however, IFN-α treatment failure in CHB patients is a challenging obstacle with 70% of CHB patients respond poorly to exogenous IFN-α treatment. The IFN-α treatment response is negatively regulated by both viral and host factors, and the role of viral factors has been extensively illustrated, while much less attention has been paid to host negative factors. Here, we summarized evidence of host negative regulators and parameters involved in IFN-α therapy failure, review the mechanisms responsible for these effects, and discuss the possible improvement of IFN-based therapy and the rationale of combining the inhibitors of negative regulators in achieving an HBV cure.Jiayi WangJiayi WangLingyao DuLingyao DuHong TangHong TangFrontiers Media S.A.articlechronic hepatitis Binterferon-αnegative regulatorshost factorsnon-responseMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic hepatitis B interferon-α negative regulators host factors non-response Medicine (General) R5-920
spellingShingle	chronic hepatitis B interferon-α negative regulators host factors non-response Medicine (General) R5-920 Jiayi Wang Jiayi Wang Lingyao Du Lingyao Du Hong Tang Hong Tang Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
description	Chronic hepatitis B virus (CHB) infection remains a major global public health issue for which there is still lacking effective curative treatment. Interferon-α (IFN-α) and its pegylated form have been approved as an anti-HBV drug with the advantage of antiviral activity and host immunity against HBV infection enhancement, however, IFN-α treatment failure in CHB patients is a challenging obstacle with 70% of CHB patients respond poorly to exogenous IFN-α treatment. The IFN-α treatment response is negatively regulated by both viral and host factors, and the role of viral factors has been extensively illustrated, while much less attention has been paid to host negative factors. Here, we summarized evidence of host negative regulators and parameters involved in IFN-α therapy failure, review the mechanisms responsible for these effects, and discuss the possible improvement of IFN-based therapy and the rationale of combining the inhibitors of negative regulators in achieving an HBV cure.
format	article
author	Jiayi Wang Jiayi Wang Lingyao Du Lingyao Du Hong Tang Hong Tang
author_facet	Jiayi Wang Jiayi Wang Lingyao Du Lingyao Du Hong Tang Hong Tang
author_sort	Jiayi Wang
title	Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
title_short	Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
title_full	Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
title_fullStr	Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
title_full_unstemmed	Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection
title_sort	suppression of interferon-α treatment response by host negative factors in hepatitis b virus infection
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/71acc532ea334bc291e7c65f66355067
work_keys_str_mv	AT jiayiwang suppressionofinterferonatreatmentresponsebyhostnegativefactorsinhepatitisbvirusinfection AT jiayiwang suppressionofinterferonatreatmentresponsebyhostnegativefactorsinhepatitisbvirusinfection AT lingyaodu suppressionofinterferonatreatmentresponsebyhostnegativefactorsinhepatitisbvirusinfection AT lingyaodu suppressionofinterferonatreatmentresponsebyhostnegativefactorsinhepatitisbvirusinfection AT hongtang suppressionofinterferonatreatmentresponsebyhostnegativefactorsinhepatitisbvirusinfection AT hongtang suppressionofinterferonatreatmentresponsebyhostnegativefactorsinhepatitisbvirusinfection
_version_	1718406449800937472

Suppression of Interferon-α Treatment Response by Host Negative Factors in Hepatitis B Virus Infection

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