c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration.

Adult muscle stem cells, satellite cells (SCs), endow skeletal muscle with tremendous regenerative capacity. Upon injury, SCs activate, proliferate, and migrate as myoblasts to the injury site where they become myocytes that fuse to form new muscle. How migration is regulated, though, remains largel...

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Autores principales:	Micah T Webster, Chen-Ming Fan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/71aced3d9d5c4bcb935c66625e403729
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spelling	oai:doaj.org-article:71aced3d9d5c4bcb935c66625e4037292021-11-18T08:45:48Zc-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration.1932-620310.1371/journal.pone.0081757https://doaj.org/article/71aced3d9d5c4bcb935c66625e4037292013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260586/?tool=EBIhttps://doaj.org/toc/1932-6203Adult muscle stem cells, satellite cells (SCs), endow skeletal muscle with tremendous regenerative capacity. Upon injury, SCs activate, proliferate, and migrate as myoblasts to the injury site where they become myocytes that fuse to form new muscle. How migration is regulated, though, remains largely unknown. Additionally, how migration and fusion, which both require dynamic rearrangement of the cytoskeleton, might be related is not well understood. c-MET, a receptor tyrosine kinase, is required for myogenic precursor cell migration into the limb for muscle development during embryogenesis. Using a genetic system to eliminate c-MET function specifically in adult mouse SCs, we found that c-MET was required for muscle regeneration in response to acute muscle injury. c-MET mutant myoblasts were defective in lamellipodia formation, had shorter ranges of migration, and migrated slower compared to control myoblasts. Surprisingly, c-MET was also required for efficient myocyte fusion, implicating c-MET in dual functions of regulating myoblast migration and myocyte fusion.Micah T WebsterChen-Ming FanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e81757 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Micah T Webster Chen-Ming Fan c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration.
description	Adult muscle stem cells, satellite cells (SCs), endow skeletal muscle with tremendous regenerative capacity. Upon injury, SCs activate, proliferate, and migrate as myoblasts to the injury site where they become myocytes that fuse to form new muscle. How migration is regulated, though, remains largely unknown. Additionally, how migration and fusion, which both require dynamic rearrangement of the cytoskeleton, might be related is not well understood. c-MET, a receptor tyrosine kinase, is required for myogenic precursor cell migration into the limb for muscle development during embryogenesis. Using a genetic system to eliminate c-MET function specifically in adult mouse SCs, we found that c-MET was required for muscle regeneration in response to acute muscle injury. c-MET mutant myoblasts were defective in lamellipodia formation, had shorter ranges of migration, and migrated slower compared to control myoblasts. Surprisingly, c-MET was also required for efficient myocyte fusion, implicating c-MET in dual functions of regulating myoblast migration and myocyte fusion.
format	article
author	Micah T Webster Chen-Ming Fan
author_facet	Micah T Webster Chen-Ming Fan
author_sort	Micah T Webster
title	c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration.
title_short	c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration.
title_full	c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration.
title_fullStr	c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration.
title_full_unstemmed	c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration.
title_sort	c-met regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/71aced3d9d5c4bcb935c66625e403729
work_keys_str_mv	AT micahtwebster cmetregulatesmyoblastmotilityandmyocytefusionduringadultskeletalmuscleregeneration AT chenmingfan cmetregulatesmyoblastmotilityandmyocytefusionduringadultskeletalmuscleregeneration
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c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration.

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