TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients

The human endogenous retrovirus-K (HERV-K) and TAR DNA-binding protein 43 (TDP-43) have been associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). Given these findings, we investigated the humoral response against HERV-K envelope surface (env-su) glycoprotein antigens and TDP-4...

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Autores principales:	Elena Rita Simula, Giannina Arru, Ignazio Roberto Zarbo, Paolo Solla, Leonardo A. Sechi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ALS amyotrophic lateral sclerosis TDP-43 HERV-K HML-2 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/71ad022f1e4b44b28b4fa235c8a5e305
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spelling	oai:doaj.org-article:71ad022f1e4b44b28b4fa235c8a5e3052021-11-25T19:14:21ZTDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients10.3390/v131123011999-4915https://doaj.org/article/71ad022f1e4b44b28b4fa235c8a5e3052021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2301https://doaj.org/toc/1999-4915The human endogenous retrovirus-K (HERV-K) and TAR DNA-binding protein 43 (TDP-43) have been associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). Given these findings, we investigated the humoral response against HERV-K envelope surface (env-su) glycoprotein antigens and TDP-43 in the plasma of ALS patients and healthy controls (HCs). The measured levels of Abs against the different epitopes’ fragments were significantly elevated in ALS patients, both in long-survivor (LS) and newly diagnosed (ND) patients, compared to HCs. We observed a positive correlation between HERV-K and TDP-43 antibodies (Abs) levels, which seemed to strengthen with disease progression, that was not found in HCs. The TDP-43 and HERV-K epitopes identified in this study are highly immunogenic and recognized by the humoral response of ALS patients. Increased circulating levels of Abs directed against specific HERV-K- and TDP-43-derived epitopes could serve as possible biomarkers.Elena Rita SimulaGiannina ArruIgnazio Roberto ZarboPaolo SollaLeonardo A. SechiMDPI AGarticleALSamyotrophic lateral sclerosisTDP-43HERV-KHML-2MicrobiologyQR1-502ENViruses, Vol 13, Iss 2301, p 2301 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ALS amyotrophic lateral sclerosis TDP-43 HERV-K HML-2 Microbiology QR1-502
spellingShingle	ALS amyotrophic lateral sclerosis TDP-43 HERV-K HML-2 Microbiology QR1-502 Elena Rita Simula Giannina Arru Ignazio Roberto Zarbo Paolo Solla Leonardo A. Sechi TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients
description	The human endogenous retrovirus-K (HERV-K) and TAR DNA-binding protein 43 (TDP-43) have been associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). Given these findings, we investigated the humoral response against HERV-K envelope surface (env-su) glycoprotein antigens and TDP-43 in the plasma of ALS patients and healthy controls (HCs). The measured levels of Abs against the different epitopes’ fragments were significantly elevated in ALS patients, both in long-survivor (LS) and newly diagnosed (ND) patients, compared to HCs. We observed a positive correlation between HERV-K and TDP-43 antibodies (Abs) levels, which seemed to strengthen with disease progression, that was not found in HCs. The TDP-43 and HERV-K epitopes identified in this study are highly immunogenic and recognized by the humoral response of ALS patients. Increased circulating levels of Abs directed against specific HERV-K- and TDP-43-derived epitopes could serve as possible biomarkers.
format	article
author	Elena Rita Simula Giannina Arru Ignazio Roberto Zarbo Paolo Solla Leonardo A. Sechi
author_facet	Elena Rita Simula Giannina Arru Ignazio Roberto Zarbo Paolo Solla Leonardo A. Sechi
author_sort	Elena Rita Simula
title	TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients
title_short	TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients
title_full	TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients
title_fullStr	TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients
title_full_unstemmed	TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients
title_sort	tdp-43 and herv-k envelope-specific immunogenic epitopes are recognized in als patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/71ad022f1e4b44b28b4fa235c8a5e305
work_keys_str_mv	AT elenaritasimula tdp43andhervkenvelopespecificimmunogenicepitopesarerecognizedinalspatients AT gianninaarru tdp43andhervkenvelopespecificimmunogenicepitopesarerecognizedinalspatients AT ignaziorobertozarbo tdp43andhervkenvelopespecificimmunogenicepitopesarerecognizedinalspatients AT paolosolla tdp43andhervkenvelopespecificimmunogenicepitopesarerecognizedinalspatients AT leonardoasechi tdp43andhervkenvelopespecificimmunogenicepitopesarerecognizedinalspatients
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TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients

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