A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates

Polyfluorinated hexopyranoses display unique physical, chemical and biological properties, however their stereoselective synthesis is highly challenging. Here, the authors report a synthetic approach based on the chemical manipulation of inexpensive levoglucosan to obtain heavily fluorinated monosac...

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Autores principales: Vincent Denavit, Danny Lainé, Jacob St-Gelais, Paul A. Johnson, Denis Giguère
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/71b3d4d6b81340a39a931d5a0fa20843
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Sumario:Polyfluorinated hexopyranoses display unique physical, chemical and biological properties, however their stereoselective synthesis is highly challenging. Here, the authors report a synthetic approach based on the chemical manipulation of inexpensive levoglucosan to obtain heavily fluorinated monosaccharides stereoselectively.