Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections <italic toggle="yes">In Situ</italic>

ABSTRACT Molecular imaging is an emerging technology that enables the noninvasive visualization, characterization, and quantification of molecular events within living subjects. Positron emission tomography (PET) is a clinically available molecular imaging tool with significant potential to study pa...

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Autores principales:	Oren Gordon, Camilo A. Ruiz-Bedoya, Alvaro A. Ordonez, Elizabeth W. Tucker, Sanjay K. Jain
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	heterogeneity infectious disease molecular imaging pathogenesis positron emission tomography Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/71b60b8796034205b62ab70c7288aad2
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spelling	oai:doaj.org-article:71b60b8796034205b62ab70c7288aad22021-11-15T15:59:42ZMolecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections <italic toggle="yes">In Situ</italic>10.1128/mBio.00317-192150-7511https://doaj.org/article/71b60b8796034205b62ab70c7288aad22019-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00317-19https://doaj.org/toc/2150-7511ABSTRACT Molecular imaging is an emerging technology that enables the noninvasive visualization, characterization, and quantification of molecular events within living subjects. Positron emission tomography (PET) is a clinically available molecular imaging tool with significant potential to study pathogenesis of infections in humans. PET enables dynamic assessment of infectious processes within the same subject with high temporal and spatial resolution and obviates the need for invasive tissue sampling, which is difficult in patients and generally limited to a single time point, even in animal models. This review presents current state-of-the-art concepts on the application of molecular imaging for infectious diseases and details how PET imaging can facilitate novel insights into infectious processes, ongoing development of pathogen-specific imaging, and simultaneous in situ measurements of intralesional antimicrobial pharmacokinetics in multiple compartments, including privileged sites. Finally, the potential clinical applications of this promising technology are also discussed.Oren GordonCamilo A. Ruiz-BedoyaAlvaro A. OrdonezElizabeth W. TuckerSanjay K. JainAmerican Society for Microbiologyarticleheterogeneityinfectious diseasemolecular imagingpathogenesispositron emission tomographyMicrobiologyQR1-502ENmBio, Vol 10, Iss 5 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	heterogeneity infectious disease molecular imaging pathogenesis positron emission tomography Microbiology QR1-502
spellingShingle	heterogeneity infectious disease molecular imaging pathogenesis positron emission tomography Microbiology QR1-502 Oren Gordon Camilo A. Ruiz-Bedoya Alvaro A. Ordonez Elizabeth W. Tucker Sanjay K. Jain Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections <italic toggle="yes">In Situ</italic>
description	ABSTRACT Molecular imaging is an emerging technology that enables the noninvasive visualization, characterization, and quantification of molecular events within living subjects. Positron emission tomography (PET) is a clinically available molecular imaging tool with significant potential to study pathogenesis of infections in humans. PET enables dynamic assessment of infectious processes within the same subject with high temporal and spatial resolution and obviates the need for invasive tissue sampling, which is difficult in patients and generally limited to a single time point, even in animal models. This review presents current state-of-the-art concepts on the application of molecular imaging for infectious diseases and details how PET imaging can facilitate novel insights into infectious processes, ongoing development of pathogen-specific imaging, and simultaneous in situ measurements of intralesional antimicrobial pharmacokinetics in multiple compartments, including privileged sites. Finally, the potential clinical applications of this promising technology are also discussed.
format	article
author	Oren Gordon Camilo A. Ruiz-Bedoya Alvaro A. Ordonez Elizabeth W. Tucker Sanjay K. Jain
author_facet	Oren Gordon Camilo A. Ruiz-Bedoya Alvaro A. Ordonez Elizabeth W. Tucker Sanjay K. Jain
author_sort	Oren Gordon
title	Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections <italic toggle="yes">In Situ</italic>
title_short	Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections <italic toggle="yes">In Situ</italic>
title_full	Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections <italic toggle="yes">In Situ</italic>
title_fullStr	Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections <italic toggle="yes">In Situ</italic>
title_full_unstemmed	Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections <italic toggle="yes">In Situ</italic>
title_sort	molecular imaging: a novel tool to visualize pathogenesis of infections <italic toggle="yes">in situ</italic>
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/71b60b8796034205b62ab70c7288aad2
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Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections <italic toggle="yes">In Situ</italic>

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