BK channel inactivation gates daytime excitability in the circadian clock

BK potassium channels have been previously shown to mediate SCN circadian firing, although the precise mechanisms are unclear. Here, using knockout and rescue approaches, the authors find that the ß2 ‘ball-and-chain’ confers BK channel inactivation during the day, promoting SCN electrical upstate....

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Autores principales:	Joshua P. Whitt, Jenna R. Montgomery, Andrea L. Meredith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71b72ebbc6e9459fb23474859a7f793f
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spelling	oai:doaj.org-article:71b72ebbc6e9459fb23474859a7f793f2021-12-02T17:31:18ZBK channel inactivation gates daytime excitability in the circadian clock10.1038/ncomms108372041-1723https://doaj.org/article/71b72ebbc6e9459fb23474859a7f793f2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10837https://doaj.org/toc/2041-1723BK potassium channels have been previously shown to mediate SCN circadian firing, although the precise mechanisms are unclear. Here, using knockout and rescue approaches, the authors find that the ß2 ‘ball-and-chain’ confers BK channel inactivation during the day, promoting SCN electrical upstate.Joshua P. WhittJenna R. MontgomeryAndrea L. MeredithNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua P. Whitt Jenna R. Montgomery Andrea L. Meredith BK channel inactivation gates daytime excitability in the circadian clock
description	BK potassium channels have been previously shown to mediate SCN circadian firing, although the precise mechanisms are unclear. Here, using knockout and rescue approaches, the authors find that the ß2 ‘ball-and-chain’ confers BK channel inactivation during the day, promoting SCN electrical upstate.
format	article
author	Joshua P. Whitt Jenna R. Montgomery Andrea L. Meredith
author_facet	Joshua P. Whitt Jenna R. Montgomery Andrea L. Meredith
author_sort	Joshua P. Whitt
title	BK channel inactivation gates daytime excitability in the circadian clock
title_short	BK channel inactivation gates daytime excitability in the circadian clock
title_full	BK channel inactivation gates daytime excitability in the circadian clock
title_fullStr	BK channel inactivation gates daytime excitability in the circadian clock
title_full_unstemmed	BK channel inactivation gates daytime excitability in the circadian clock
title_sort	bk channel inactivation gates daytime excitability in the circadian clock
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/71b72ebbc6e9459fb23474859a7f793f
work_keys_str_mv	AT joshuapwhitt bkchannelinactivationgatesdaytimeexcitabilityinthecircadianclock AT jennarmontgomery bkchannelinactivationgatesdaytimeexcitabilityinthecircadianclock AT andrealmeredith bkchannelinactivationgatesdaytimeexcitabilityinthecircadianclock
_version_	1718380678933905408

BK channel inactivation gates daytime excitability in the circadian clock

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