Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1

Cas9 and Cpf1 have both been adapted for genome engineering, editing and gene expression regulation. Here the authors design a fusion guide RNA that can interact with both proteins for multiple and orthogonal genome manipulation.

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Autores principales:	Jiyeon Kweon, An-Hee Jang, Da-eun Kim, Jin Wook Yang, Mijung Yoon, Ha Rim Shin, Jin-Soo Kim, Yongsub Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71bb17bf76e3494bae0588923dad639c
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spelling	oai:doaj.org-article:71bb17bf76e3494bae0588923dad639c2021-12-02T14:42:26ZFusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf110.1038/s41467-017-01650-w2041-1723https://doaj.org/article/71bb17bf76e3494bae0588923dad639c2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01650-whttps://doaj.org/toc/2041-1723Cas9 and Cpf1 have both been adapted for genome engineering, editing and gene expression regulation. Here the authors design a fusion guide RNA that can interact with both proteins for multiple and orthogonal genome manipulation.Jiyeon KweonAn-Hee JangDa-eun KimJin Wook YangMijung YoonHa Rim ShinJin-Soo KimYongsub KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiyeon Kweon An-Hee Jang Da-eun Kim Jin Wook Yang Mijung Yoon Ha Rim Shin Jin-Soo Kim Yongsub Kim Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1
description	Cas9 and Cpf1 have both been adapted for genome engineering, editing and gene expression regulation. Here the authors design a fusion guide RNA that can interact with both proteins for multiple and orthogonal genome manipulation.
format	article
author	Jiyeon Kweon An-Hee Jang Da-eun Kim Jin Wook Yang Mijung Yoon Ha Rim Shin Jin-Soo Kim Yongsub Kim
author_facet	Jiyeon Kweon An-Hee Jang Da-eun Kim Jin Wook Yang Mijung Yoon Ha Rim Shin Jin-Soo Kim Yongsub Kim
author_sort	Jiyeon Kweon
title	Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1
title_short	Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1
title_full	Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1
title_fullStr	Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1
title_full_unstemmed	Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1
title_sort	fusion guide rnas for orthogonal gene manipulation with cas9 and cpf1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/71bb17bf76e3494bae0588923dad639c
work_keys_str_mv	AT jiyeonkweon fusionguidernasfororthogonalgenemanipulationwithcas9andcpf1 AT anheejang fusionguidernasfororthogonalgenemanipulationwithcas9andcpf1 AT daeunkim fusionguidernasfororthogonalgenemanipulationwithcas9andcpf1 AT jinwookyang fusionguidernasfororthogonalgenemanipulationwithcas9andcpf1 AT mijungyoon fusionguidernasfororthogonalgenemanipulationwithcas9andcpf1 AT harimshin fusionguidernasfororthogonalgenemanipulationwithcas9andcpf1 AT jinsookim fusionguidernasfororthogonalgenemanipulationwithcas9andcpf1 AT yongsubkim fusionguidernasfororthogonalgenemanipulationwithcas9andcpf1
_version_	1718389694860886016

Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1

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