A combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011–2014

Abstract Campylobacter infection is the most commonly notified bacterial enteritis in Germany. We performed a large combined case-control and source attribution study (Nov 2011-Feb 2014) to identify risk factors for sporadic intestinal Campylobacter infections and to determine the relative importanc...

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Autores principales:	Bettina M. Rosner, Anika Schielke, Xavier Didelot, Friederike Kops, Janina Breidenbach, Niklas Willrich, Greta Gölz, Thomas Alter, Kerstin Stingl, Christine Josenhans, Sebastian Suerbaum, Klaus Stark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/71be4e1789be48908c73ae854f21cfaf
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spelling	oai:doaj.org-article:71be4e1789be48908c73ae854f21cfaf2021-12-02T16:06:50ZA combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011–201410.1038/s41598-017-05227-x2045-2322https://doaj.org/article/71be4e1789be48908c73ae854f21cfaf2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05227-xhttps://doaj.org/toc/2045-2322Abstract Campylobacter infection is the most commonly notified bacterial enteritis in Germany. We performed a large combined case-control and source attribution study (Nov 2011-Feb 2014) to identify risk factors for sporadic intestinal Campylobacter infections and to determine the relative importance of various animal sources for human infections in Germany. We conducted multivariable logistic regression analysis to identify risk factors. Source attribution analysis was performed using the asymmetric island model based on MLST data of human and animal/food isolates. As animal sources we considered chicken, pig, pet dog or cat, cattle, and poultry other than chicken. Consumption of chicken meat and eating out were the most important risk factors for Campylobacter infections. Additional risk factors were preparation of poultry meat in the household; preparation of uncooked food and raw meat at the same time; contact with poultry animals; and the use of gastric acid inhibitors. The mean probability of human C. jejuni isolates to originate from chickens was highest (74%), whereas pigs were a negligible source for C. jejuni infections. Human C. coli isolates were likely to originate from chickens (56%) or from pigs (32%). Efforts need to be intensified along the food chain to reduce Campylobacter load, especially on chicken meat.Bettina M. RosnerAnika SchielkeXavier DidelotFriederike KopsJanina BreidenbachNiklas WillrichGreta GölzThomas AlterKerstin StinglChristine JosenhansSebastian SuerbaumKlaus StarkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bettina M. Rosner Anika Schielke Xavier Didelot Friederike Kops Janina Breidenbach Niklas Willrich Greta Gölz Thomas Alter Kerstin Stingl Christine Josenhans Sebastian Suerbaum Klaus Stark A combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011–2014
description	Abstract Campylobacter infection is the most commonly notified bacterial enteritis in Germany. We performed a large combined case-control and source attribution study (Nov 2011-Feb 2014) to identify risk factors for sporadic intestinal Campylobacter infections and to determine the relative importance of various animal sources for human infections in Germany. We conducted multivariable logistic regression analysis to identify risk factors. Source attribution analysis was performed using the asymmetric island model based on MLST data of human and animal/food isolates. As animal sources we considered chicken, pig, pet dog or cat, cattle, and poultry other than chicken. Consumption of chicken meat and eating out were the most important risk factors for Campylobacter infections. Additional risk factors were preparation of poultry meat in the household; preparation of uncooked food and raw meat at the same time; contact with poultry animals; and the use of gastric acid inhibitors. The mean probability of human C. jejuni isolates to originate from chickens was highest (74%), whereas pigs were a negligible source for C. jejuni infections. Human C. coli isolates were likely to originate from chickens (56%) or from pigs (32%). Efforts need to be intensified along the food chain to reduce Campylobacter load, especially on chicken meat.
format	article
author	Bettina M. Rosner Anika Schielke Xavier Didelot Friederike Kops Janina Breidenbach Niklas Willrich Greta Gölz Thomas Alter Kerstin Stingl Christine Josenhans Sebastian Suerbaum Klaus Stark
author_facet	Bettina M. Rosner Anika Schielke Xavier Didelot Friederike Kops Janina Breidenbach Niklas Willrich Greta Gölz Thomas Alter Kerstin Stingl Christine Josenhans Sebastian Suerbaum Klaus Stark
author_sort	Bettina M. Rosner
title	A combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011–2014
title_short	A combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011–2014
title_full	A combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011–2014
title_fullStr	A combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011–2014
title_full_unstemmed	A combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011–2014
title_sort	combined case-control and molecular source attribution study of human campylobacter infections in germany, 2011–2014
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/71be4e1789be48908c73ae854f21cfaf
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A combined case-control and molecular source attribution study of human Campylobacter infections in Germany, 2011–2014

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