Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions

Hossein Derakhshankhah, 1, 2,* Samira Jafari, 1, 2,* Sajad Sarvari, 3 Ebrahim Barzegari, 4 Faezeh Moakedi, 5 Milad Ghorbani, 6 Behrang Shiri Varnamkhasti, 1 Mehdi Jaymand, 7 Zhila Izadi, 1, 8 Lobat Tayebi 9 1Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical...

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Autores principales:	Derakhshankhah H, Jafari S, Sarvari S, Barzegari E, Moakedi F, Ghorbani M, Shiri Varnamkhasti B, Jaymand M, Izadi Z, Tayebi L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	zeolite mesoporous nanostructure biosafety biomedical application Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/71beb24d7d8a4ee1a8c5d0ae54f66809
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spelling	oai:doaj.org-article:71beb24d7d8a4ee1a8c5d0ae54f668092021-12-02T09:43:40ZBiomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions1178-2013https://doaj.org/article/71beb24d7d8a4ee1a8c5d0ae54f668092020-01-01T00:00:00Zhttps://www.dovepress.com/biomedical-applications-of-zeolitic-nanoparticles-with-an-emphasis-on--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hossein Derakhshankhah, 1, 2,* Samira Jafari, 1, 2,* Sajad Sarvari, 3 Ebrahim Barzegari, 4 Faezeh Moakedi, 5 Milad Ghorbani, 6 Behrang Shiri Varnamkhasti, 1 Mehdi Jaymand, 7 Zhila Izadi, 1, 8 Lobat Tayebi 9 1Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Zistmavad Pharmed Co., Tehran, Iran; 3Department of Pharmaceutical and Pharmacological Science, School of Medicine, West Virginia University, Morgantown, WV, USA; 4Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Department of Biochemistry and Molecular Biology, School of Medicine, West Virginia University, Morgantown, WV, USA; 6Department of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran; 7Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 8Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; 9Marquette University School of Dentistry, Milwaukee, WI 53201, USA*These authors contributed equally to this workCorrespondence: Zhila Izadi; Lobat Tayebi Email izadi_zh@razi.tums.ac.ir; lobat.tayebi@marquette.eduAbstract: The advent of porous materials, in particular zeolitic nanoparticles, has opened up unprecedented putative research avenues in nanomedicine. Zeolites with intracrystal mesopores are low framework density aluminosilicates possessing a regular porous structure along with intricate channels. Their unique physiochemical as well as physiological parameters necessitate a comprehensive overview on their classifications, fabrication platforms, cellular/macromolecular interactions, and eventually their prospective biomedical applications through illustrating the challenges and opportunities in different integrative medical and pharmaceutical fields. More particularly, an update on recent advances in zeolite-accommodated drug delivery and the prevalent challenges regarding these molecular sieves is to be presented. In conclusion, strategies to accelerate the translation of these porous materials from bench to bedside along with common overlooked physiological and pharmacological factors of zeolite nanoparticles are discussed and debated. Furthermore, for zeolite nanoparticles, it is a matter of crucial importance, in terms of biosafety and nanotoxicology, to appreciate the zeolite-bio interface once the zeolite nanoparticles are exposed to the bio-macromolecules in biological media. We specifically shed light on interactions of zeolite nanoparticles with fibrinogen and amyloid beta which had been comprehensively investigated in our recent reports. Given the significance of zeolite nanoparticles’ interactions with serum or interstitial proteins conferring them new biological identity, the preliminary approaches for deeper understanding of administration, distribution, metabolism and excretion of zeolite nanoparticles are elucidated.Keywords: zeolite, mesoporous, nanostructure, biosafety, biomedical applicationsDerakhshankhah HJafari SSarvari SBarzegari EMoakedi FGhorbani MShiri Varnamkhasti BJaymand MIzadi ZTayebi LDove Medical Pressarticlezeolitemesoporousnanostructurebiosafetybiomedical applicationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 363-386 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	zeolite mesoporous nanostructure biosafety biomedical application Medicine (General) R5-920
spellingShingle	zeolite mesoporous nanostructure biosafety biomedical application Medicine (General) R5-920 Derakhshankhah H Jafari S Sarvari S Barzegari E Moakedi F Ghorbani M Shiri Varnamkhasti B Jaymand M Izadi Z Tayebi L Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions
description	Hossein Derakhshankhah, 1, 2,* Samira Jafari, 1, 2,* Sajad Sarvari, 3 Ebrahim Barzegari, 4 Faezeh Moakedi, 5 Milad Ghorbani, 6 Behrang Shiri Varnamkhasti, 1 Mehdi Jaymand, 7 Zhila Izadi, 1, 8 Lobat Tayebi 9 1Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Zistmavad Pharmed Co., Tehran, Iran; 3Department of Pharmaceutical and Pharmacological Science, School of Medicine, West Virginia University, Morgantown, WV, USA; 4Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Department of Biochemistry and Molecular Biology, School of Medicine, West Virginia University, Morgantown, WV, USA; 6Department of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran; 7Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 8Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; 9Marquette University School of Dentistry, Milwaukee, WI 53201, USA*These authors contributed equally to this workCorrespondence: Zhila Izadi; Lobat Tayebi Email izadi_zh@razi.tums.ac.ir; lobat.tayebi@marquette.eduAbstract: The advent of porous materials, in particular zeolitic nanoparticles, has opened up unprecedented putative research avenues in nanomedicine. Zeolites with intracrystal mesopores are low framework density aluminosilicates possessing a regular porous structure along with intricate channels. Their unique physiochemical as well as physiological parameters necessitate a comprehensive overview on their classifications, fabrication platforms, cellular/macromolecular interactions, and eventually their prospective biomedical applications through illustrating the challenges and opportunities in different integrative medical and pharmaceutical fields. More particularly, an update on recent advances in zeolite-accommodated drug delivery and the prevalent challenges regarding these molecular sieves is to be presented. In conclusion, strategies to accelerate the translation of these porous materials from bench to bedside along with common overlooked physiological and pharmacological factors of zeolite nanoparticles are discussed and debated. Furthermore, for zeolite nanoparticles, it is a matter of crucial importance, in terms of biosafety and nanotoxicology, to appreciate the zeolite-bio interface once the zeolite nanoparticles are exposed to the bio-macromolecules in biological media. We specifically shed light on interactions of zeolite nanoparticles with fibrinogen and amyloid beta which had been comprehensively investigated in our recent reports. Given the significance of zeolite nanoparticles’ interactions with serum or interstitial proteins conferring them new biological identity, the preliminary approaches for deeper understanding of administration, distribution, metabolism and excretion of zeolite nanoparticles are elucidated.Keywords: zeolite, mesoporous, nanostructure, biosafety, biomedical applications
format	article
author	Derakhshankhah H Jafari S Sarvari S Barzegari E Moakedi F Ghorbani M Shiri Varnamkhasti B Jaymand M Izadi Z Tayebi L
author_facet	Derakhshankhah H Jafari S Sarvari S Barzegari E Moakedi F Ghorbani M Shiri Varnamkhasti B Jaymand M Izadi Z Tayebi L
author_sort	Derakhshankhah H
title	Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions
title_short	Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions
title_full	Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions
title_fullStr	Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions
title_full_unstemmed	Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions
title_sort	biomedical applications of zeolitic nanoparticles, with an emphasis on medical interventions
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/71beb24d7d8a4ee1a8c5d0ae54f66809
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Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions

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