Insight Into the Roles of Non-coding RNA in Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly occurring in premature infants, and its pathological manifestations are alveolar hypoplasia and dysregulation of pulmonary vasculature development. The effective treatment for BPD has not yet been established. Non-coding RNAs,...

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Autores principales:	Yufeng Xi, Yujia Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bronchopulmonary dysplasia premature infants noncoding RNA microRNA long non-coding RNA Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/71c03c164f484dfabf421fbce07675bc
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spelling	oai:doaj.org-article:71c03c164f484dfabf421fbce07675bc2021-11-05T07:17:15ZInsight Into the Roles of Non-coding RNA in Bronchopulmonary Dysplasia2296-858X10.3389/fmed.2021.761724https://doaj.org/article/71c03c164f484dfabf421fbce07675bc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.761724/fullhttps://doaj.org/toc/2296-858XBronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly occurring in premature infants, and its pathological manifestations are alveolar hypoplasia and dysregulation of pulmonary vasculature development. The effective treatment for BPD has not yet been established. Non-coding RNAs, including microRNAs and long non-coding RNAs do not encode proteins, but can perform its biological functions at the RNA level. Non-coding RNAs play an important role in the incidence and development of BPD by regulating the expression of genes related to proliferation, apoptosis, angiogenesis, inflammation and other cell activities of alveolar epithelial cells and vascular endothelial cells. Here we summarize the role of non-coding RNAs in BPD, which provides possible molecular marker and therapeutic target for the diagnosis and treatment of BPD.Yufeng XiYujia WangYujia WangFrontiers Media S.A.articlebronchopulmonary dysplasiapremature infantsnoncoding RNAmicroRNAlong non-coding RNAMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bronchopulmonary dysplasia premature infants noncoding RNA microRNA long non-coding RNA Medicine (General) R5-920
spellingShingle	bronchopulmonary dysplasia premature infants noncoding RNA microRNA long non-coding RNA Medicine (General) R5-920 Yufeng Xi Yujia Wang Yujia Wang Insight Into the Roles of Non-coding RNA in Bronchopulmonary Dysplasia
description	Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly occurring in premature infants, and its pathological manifestations are alveolar hypoplasia and dysregulation of pulmonary vasculature development. The effective treatment for BPD has not yet been established. Non-coding RNAs, including microRNAs and long non-coding RNAs do not encode proteins, but can perform its biological functions at the RNA level. Non-coding RNAs play an important role in the incidence and development of BPD by regulating the expression of genes related to proliferation, apoptosis, angiogenesis, inflammation and other cell activities of alveolar epithelial cells and vascular endothelial cells. Here we summarize the role of non-coding RNAs in BPD, which provides possible molecular marker and therapeutic target for the diagnosis and treatment of BPD.
format	article
author	Yufeng Xi Yujia Wang Yujia Wang
author_facet	Yufeng Xi Yujia Wang Yujia Wang
author_sort	Yufeng Xi
title	Insight Into the Roles of Non-coding RNA in Bronchopulmonary Dysplasia
title_short	Insight Into the Roles of Non-coding RNA in Bronchopulmonary Dysplasia
title_full	Insight Into the Roles of Non-coding RNA in Bronchopulmonary Dysplasia
title_fullStr	Insight Into the Roles of Non-coding RNA in Bronchopulmonary Dysplasia
title_full_unstemmed	Insight Into the Roles of Non-coding RNA in Bronchopulmonary Dysplasia
title_sort	insight into the roles of non-coding rna in bronchopulmonary dysplasia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/71c03c164f484dfabf421fbce07675bc
work_keys_str_mv	AT yufengxi insightintotherolesofnoncodingrnainbronchopulmonarydysplasia AT yujiawang insightintotherolesofnoncodingrnainbronchopulmonarydysplasia AT yujiawang insightintotherolesofnoncodingrnainbronchopulmonarydysplasia
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Insight Into the Roles of Non-coding RNA in Bronchopulmonary Dysplasia

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