Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage
Abstract TroponinT levels are frequently elevated after subarachnoid hemorrhage (SAH). However, their clinical impact on long term outcomes still remains unclear. This study evaluates the association of TroponinT and functional outcomes 3 months after SAH. Data were obtained in the frame of a random...
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Nature Portfolio
2021
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oai:doaj.org-article:71c37d324d2644e58d4ec3069c4ea0272021-12-02T18:50:51ZAssociation of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage10.1038/s41598-021-95717-w2045-2322https://doaj.org/article/71c37d324d2644e58d4ec3069c4ea0272021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95717-whttps://doaj.org/toc/2045-2322Abstract TroponinT levels are frequently elevated after subarachnoid hemorrhage (SAH). However, their clinical impact on long term outcomes still remains unclear. This study evaluates the association of TroponinT and functional outcomes 3 months after SAH. Data were obtained in the frame of a randomized controlled trial exploring the association of Goal-directed hemodynamic therapy and outcomes after SAH (NCT01832389). TroponinT was measured daily for the first 14 days after admission or until discharge from the ICU. Outcome was assessed using Glasgow Outcome Scale (GOS) 3 months after discharge. Logistic regression was used to explore the association between initial TroponinT values stratified by tertiles and admission as well as outcome parameters. TroponinT measurements were analyzed in 105 patients. TroponinT values at admission were associated with outcome assessed by GOS in a univariate analysis. TroponinT was not predictive of vasospasm or delayed cerebral ischemia, but an association with pulmonary and cardiac complications was observed. After adjustment for age, history of arterial hypertension and World Federation of Neurosurgical Societies (WFNS) grade, TroponinT levels at admission were not independently associated with worse outcome (GOS 1–3) or death at 3 months. In summary, TroponinT levels at admission are associated with 3 months-GOS but have limited ability to independently predict outcome after SAH.Aida AnetsbergerBettina JungwirthManfred BlobnerFlorian RingelIsabell BernlochnerMarkus HeimRalph BogdanskiMaria WostrackGerhard SchneiderBernhard MeyerMartin GraeßnerLea BaumgartJens GemptNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Aida Anetsberger Bettina Jungwirth Manfred Blobner Florian Ringel Isabell Bernlochner Markus Heim Ralph Bogdanski Maria Wostrack Gerhard Schneider Bernhard Meyer Martin Graeßner Lea Baumgart Jens Gempt Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage |
| description |
Abstract TroponinT levels are frequently elevated after subarachnoid hemorrhage (SAH). However, their clinical impact on long term outcomes still remains unclear. This study evaluates the association of TroponinT and functional outcomes 3 months after SAH. Data were obtained in the frame of a randomized controlled trial exploring the association of Goal-directed hemodynamic therapy and outcomes after SAH (NCT01832389). TroponinT was measured daily for the first 14 days after admission or until discharge from the ICU. Outcome was assessed using Glasgow Outcome Scale (GOS) 3 months after discharge. Logistic regression was used to explore the association between initial TroponinT values stratified by tertiles and admission as well as outcome parameters. TroponinT measurements were analyzed in 105 patients. TroponinT values at admission were associated with outcome assessed by GOS in a univariate analysis. TroponinT was not predictive of vasospasm or delayed cerebral ischemia, but an association with pulmonary and cardiac complications was observed. After adjustment for age, history of arterial hypertension and World Federation of Neurosurgical Societies (WFNS) grade, TroponinT levels at admission were not independently associated with worse outcome (GOS 1–3) or death at 3 months. In summary, TroponinT levels at admission are associated with 3 months-GOS but have limited ability to independently predict outcome after SAH. |
| format |
article |
| author |
Aida Anetsberger Bettina Jungwirth Manfred Blobner Florian Ringel Isabell Bernlochner Markus Heim Ralph Bogdanski Maria Wostrack Gerhard Schneider Bernhard Meyer Martin Graeßner Lea Baumgart Jens Gempt |
| author_facet |
Aida Anetsberger Bettina Jungwirth Manfred Blobner Florian Ringel Isabell Bernlochner Markus Heim Ralph Bogdanski Maria Wostrack Gerhard Schneider Bernhard Meyer Martin Graeßner Lea Baumgart Jens Gempt |
| author_sort |
Aida Anetsberger |
| title |
Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage |
| title_short |
Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage |
| title_full |
Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage |
| title_fullStr |
Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage |
| title_full_unstemmed |
Association of Troponin T levels and functional outcome 3 months after subarachnoid hemorrhage |
| title_sort |
association of troponin t levels and functional outcome 3 months after subarachnoid hemorrhage |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/71c37d324d2644e58d4ec3069c4ea027 |
| work_keys_str_mv |
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