Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines

Our effort to find new material for anti cancer from natural resources leads us to focus on stingless bee products such as honey, bee pollen, and propolis. The products were from seven stingless bees named Homotrigona fimbriata, Heterotrigona itama, Heterotrigona bakeri, Tetragonula sarawakensis, Te...

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Autores principales:	Enos Tangke Arung, Rico Ramadhan, Binti Khairunnisa, Yhiya Amen, Masako Matsumoto, Maki Nagata, Irawan Wijaya Kusuma, Swandari Paramita, Sukemi, Yadi, Nataniel Tandirogang, Naomichi Takemoto, Syafrizal, Yong-ung Kim, Kuniyoshi Shimizu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Stingless bees Honey Bee pollen Propolis Cytotoxicity H. fimbriata Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/71c7d67d69d341c58f12c7bfc858799e
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spelling	oai:doaj.org-article:71c7d67d69d341c58f12c7bfc858799e2021-11-20T04:56:51ZCytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines1319-562X10.1016/j.sjbs.2021.08.017https://doaj.org/article/71c7d67d69d341c58f12c7bfc858799e2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21006926https://doaj.org/toc/1319-562XOur effort to find new material for anti cancer from natural resources leads us to focus on stingless bee products such as honey, bee pollen, and propolis. The products were from seven stingless bees named Homotrigona fimbriata, Heterotrigona itama, Heterotrigona bakeri, Tetragonula sarawakensis, Tetragonula testaceitarsis, Tetragonula fuscobalteata, Tetragonula laeviceps. The stingless bee products were evaluated for their cytotoxicity effect on MCF-7, HeLa and Caco-2 cancer cell lines. This is the first time to be reported that the honey, ethanol extracts of bee pollen and propolis of H. fimbriata displayed more potent cytotoxicity than other stingless bee products. By chromatography and biological activity-guided fractionation, ethanol extract of propolis from H. fimbriata was fractionated and isolated its active compound named mangiferonic acid. Mangiferonic acid showed a cytotoxicity effect with IC50 values 96.76 µM in MCF-7, >110.04 µM in HeLa, and > 110.04 µM in Caco-2, respectively. These results exhibited the potential of ethanol extracts from propolis of H. fimbriata to be further developed for drug and experiments to verify the function are essential.Enos Tangke ArungRico RamadhanBinti KhairunnisaYhiya AmenMasako MatsumotoMaki NagataIrawan Wijaya KusumaSwandari Paramita Sukemi YadiNataniel TandirogangNaomichi Takemoto SyafrizalYong-ung KimKuniyoshi ShimizuElsevierarticleStingless beesHoneyBee pollenPropolisCytotoxicityH. fimbriataBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 7182-7189 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Stingless bees Honey Bee pollen Propolis Cytotoxicity H. fimbriata Biology (General) QH301-705.5
spellingShingle	Stingless bees Honey Bee pollen Propolis Cytotoxicity H. fimbriata Biology (General) QH301-705.5 Enos Tangke Arung Rico Ramadhan Binti Khairunnisa Yhiya Amen Masako Matsumoto Maki Nagata Irawan Wijaya Kusuma Swandari Paramita Sukemi Yadi Nataniel Tandirogang Naomichi Takemoto Syafrizal Yong-ung Kim Kuniyoshi Shimizu Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines
description	Our effort to find new material for anti cancer from natural resources leads us to focus on stingless bee products such as honey, bee pollen, and propolis. The products were from seven stingless bees named Homotrigona fimbriata, Heterotrigona itama, Heterotrigona bakeri, Tetragonula sarawakensis, Tetragonula testaceitarsis, Tetragonula fuscobalteata, Tetragonula laeviceps. The stingless bee products were evaluated for their cytotoxicity effect on MCF-7, HeLa and Caco-2 cancer cell lines. This is the first time to be reported that the honey, ethanol extracts of bee pollen and propolis of H. fimbriata displayed more potent cytotoxicity than other stingless bee products. By chromatography and biological activity-guided fractionation, ethanol extract of propolis from H. fimbriata was fractionated and isolated its active compound named mangiferonic acid. Mangiferonic acid showed a cytotoxicity effect with IC50 values 96.76 µM in MCF-7, >110.04 µM in HeLa, and > 110.04 µM in Caco-2, respectively. These results exhibited the potential of ethanol extracts from propolis of H. fimbriata to be further developed for drug and experiments to verify the function are essential.
format	article
author	Enos Tangke Arung Rico Ramadhan Binti Khairunnisa Yhiya Amen Masako Matsumoto Maki Nagata Irawan Wijaya Kusuma Swandari Paramita Sukemi Yadi Nataniel Tandirogang Naomichi Takemoto Syafrizal Yong-ung Kim Kuniyoshi Shimizu
author_facet	Enos Tangke Arung Rico Ramadhan Binti Khairunnisa Yhiya Amen Masako Matsumoto Maki Nagata Irawan Wijaya Kusuma Swandari Paramita Sukemi Yadi Nataniel Tandirogang Naomichi Takemoto Syafrizal Yong-ung Kim Kuniyoshi Shimizu
author_sort	Enos Tangke Arung
title	Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines
title_short	Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines
title_full	Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines
title_fullStr	Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines
title_full_unstemmed	Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines
title_sort	cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/71c7d67d69d341c58f12c7bfc858799e
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Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines

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