Dopamine D2 receptor regulates cortical synaptic pruning in rodents

Synaptic pruning is important during development and synaptic plasticity. Here, the authors show that the dopamine D2 receptor (Drd2) in the anterior cingulate cortex regulates synaptic pruning, affecting LTD and behaviour in transgenic rats.

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Autores principales:	Ya-Qiang Zhang, Wei-Peng Lin, Li-Ping Huang, Bing Zhao, Cheng-Cheng Zhang, Dong-Min Yin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71c8769e016b48e790411f315415d656
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spelling	oai:doaj.org-article:71c8769e016b48e790411f315415d6562021-11-14T12:34:24ZDopamine D2 receptor regulates cortical synaptic pruning in rodents10.1038/s41467-021-26769-92041-1723https://doaj.org/article/71c8769e016b48e790411f315415d6562021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26769-9https://doaj.org/toc/2041-1723Synaptic pruning is important during development and synaptic plasticity. Here, the authors show that the dopamine D2 receptor (Drd2) in the anterior cingulate cortex regulates synaptic pruning, affecting LTD and behaviour in transgenic rats.Ya-Qiang ZhangWei-Peng LinLi-Ping HuangBing ZhaoCheng-Cheng ZhangDong-Min YinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ya-Qiang Zhang Wei-Peng Lin Li-Ping Huang Bing Zhao Cheng-Cheng Zhang Dong-Min Yin Dopamine D2 receptor regulates cortical synaptic pruning in rodents
description	Synaptic pruning is important during development and synaptic plasticity. Here, the authors show that the dopamine D2 receptor (Drd2) in the anterior cingulate cortex regulates synaptic pruning, affecting LTD and behaviour in transgenic rats.
format	article
author	Ya-Qiang Zhang Wei-Peng Lin Li-Ping Huang Bing Zhao Cheng-Cheng Zhang Dong-Min Yin
author_facet	Ya-Qiang Zhang Wei-Peng Lin Li-Ping Huang Bing Zhao Cheng-Cheng Zhang Dong-Min Yin
author_sort	Ya-Qiang Zhang
title	Dopamine D2 receptor regulates cortical synaptic pruning in rodents
title_short	Dopamine D2 receptor regulates cortical synaptic pruning in rodents
title_full	Dopamine D2 receptor regulates cortical synaptic pruning in rodents
title_fullStr	Dopamine D2 receptor regulates cortical synaptic pruning in rodents
title_full_unstemmed	Dopamine D2 receptor regulates cortical synaptic pruning in rodents
title_sort	dopamine d2 receptor regulates cortical synaptic pruning in rodents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/71c8769e016b48e790411f315415d656
work_keys_str_mv	AT yaqiangzhang dopamined2receptorregulatescorticalsynapticpruninginrodents AT weipenglin dopamined2receptorregulatescorticalsynapticpruninginrodents AT lipinghuang dopamined2receptorregulatescorticalsynapticpruninginrodents AT bingzhao dopamined2receptorregulatescorticalsynapticpruninginrodents AT chengchengzhang dopamined2receptorregulatescorticalsynapticpruninginrodents AT dongminyin dopamined2receptorregulatescorticalsynapticpruninginrodents
_version_	1718429112616353792

Dopamine D2 receptor regulates cortical synaptic pruning in rodents

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