Inherited Factor XII Deficiency—What Is the Real Concern for Neuroanesthesiologist: Bleeding or Clotting

Factor XII deficiency is a rare disorder that can complicate the perioperative management of a patient. Factor XII plays an important role in the activation of intrinsic pathway of coagulation; the deficiency, therefore, results in prolongation of activated partial thromboplastin time (aPTT). This a...

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Autores principales:	Mouleeswaran Sundaram, Sonia Bansal, Rohini M. Surve
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2020
Materias:	factor xii surgery bleeding thromboembolism Anesthesiology RD78.3-87.3
Acceso en línea:	https://doaj.org/article/71ca6c9db66e488695b63b7eb53f2605
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spelling	oai:doaj.org-article:71ca6c9db66e488695b63b7eb53f26052021-12-02T23:53:13ZInherited Factor XII Deficiency—What Is the Real Concern for Neuroanesthesiologist: Bleeding or Clotting2348-05482348-926X10.1055/s-0040-1713559https://doaj.org/article/71ca6c9db66e488695b63b7eb53f26052020-06-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1713559https://doaj.org/toc/2348-0548https://doaj.org/toc/2348-926XFactor XII deficiency is a rare disorder that can complicate the perioperative management of a patient. Factor XII plays an important role in the activation of intrinsic pathway of coagulation; the deficiency, therefore, results in prolongation of activated partial thromboplastin time (aPTT). This aPTT prolongation is expected to cause increased bleeding during surgery. However, on the contrary, in vivo isolated factor XII deficiency is associated with increased risk of thromboembolism (this risk being higher than the risk of bleeding). We report the perioperative management of a patient with factor XII deficiency who underwent cervical vertebral fusion (C1–C2) for atlantoaxial dislocation.Mouleeswaran SundaramSonia BansalRohini M. SurveThieme Medical and Scientific Publishers Pvt. Ltd.articlefactor xiisurgerybleedingthromboembolismAnesthesiologyRD78.3-87.3ENJournal of Neuroanaesthesiology and Critical Care, Vol 08, Iss 03, Pp 210-212 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	factor xii surgery bleeding thromboembolism Anesthesiology RD78.3-87.3
spellingShingle	factor xii surgery bleeding thromboembolism Anesthesiology RD78.3-87.3 Mouleeswaran Sundaram Sonia Bansal Rohini M. Surve Inherited Factor XII Deficiency—What Is the Real Concern for Neuroanesthesiologist: Bleeding or Clotting
description	Factor XII deficiency is a rare disorder that can complicate the perioperative management of a patient. Factor XII plays an important role in the activation of intrinsic pathway of coagulation; the deficiency, therefore, results in prolongation of activated partial thromboplastin time (aPTT). This aPTT prolongation is expected to cause increased bleeding during surgery. However, on the contrary, in vivo isolated factor XII deficiency is associated with increased risk of thromboembolism (this risk being higher than the risk of bleeding). We report the perioperative management of a patient with factor XII deficiency who underwent cervical vertebral fusion (C1–C2) for atlantoaxial dislocation.
format	article
author	Mouleeswaran Sundaram Sonia Bansal Rohini M. Surve
author_facet	Mouleeswaran Sundaram Sonia Bansal Rohini M. Surve
author_sort	Mouleeswaran Sundaram
title	Inherited Factor XII Deficiency—What Is the Real Concern for Neuroanesthesiologist: Bleeding or Clotting
title_short	Inherited Factor XII Deficiency—What Is the Real Concern for Neuroanesthesiologist: Bleeding or Clotting
title_full	Inherited Factor XII Deficiency—What Is the Real Concern for Neuroanesthesiologist: Bleeding or Clotting
title_fullStr	Inherited Factor XII Deficiency—What Is the Real Concern for Neuroanesthesiologist: Bleeding or Clotting
title_full_unstemmed	Inherited Factor XII Deficiency—What Is the Real Concern for Neuroanesthesiologist: Bleeding or Clotting
title_sort	inherited factor xii deficiency—what is the real concern for neuroanesthesiologist: bleeding or clotting
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2020
url	https://doaj.org/article/71ca6c9db66e488695b63b7eb53f2605
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Inherited Factor XII Deficiency—What Is the Real Concern for Neuroanesthesiologist: Bleeding or Clotting

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