Repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus.

<h4>Purpose</h4>To investigate the repeatability in corneal thickness (CT) and epithelial thickness (ET) measurements using spectral domain anterior segment optical coherence tomography (AS-OCT, REVO NX, Optopol) in keratoconus, and examine the effect of corneal crosslinking (CXL) on rep...

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Autores principales:	Ye Li, Akilesh Gokul, Charles McGhee, Mohammed Ziaei
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/71cc546004ad484aa88d483d38df18dd
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spelling	oai:doaj.org-article:71cc546004ad484aa88d483d38df18dd2021-12-02T20:05:19ZRepeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus.1932-620310.1371/journal.pone.0248350https://doaj.org/article/71cc546004ad484aa88d483d38df18dd2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0248350https://doaj.org/toc/1932-6203<h4>Purpose</h4>To investigate the repeatability in corneal thickness (CT) and epithelial thickness (ET) measurements using spectral domain anterior segment optical coherence tomography (AS-OCT, REVO NX, Optopol) in keratoconus, and examine the effect of corneal crosslinking (CXL) on repeatability.<h4>Methods</h4>A cross-sectional study of 259 eyes of 212 patients with keratoconus attending the corneal disease clinic at a university hospital tertiary referral center were enrolled. Two groups were analysed: eyes with no prior history of CXL (Group A) and eyes with prior CXL (Group B). Repeatability of measurements was assessed using the intraclass correlation coefficient (ICC) and coefficient of variation (CV).<h4>Results</h4>In Group A, central corneal thickness (CCT) was 472.18 ± 45.41μm, and the ET was found to be the thinnest in the inferior-temporal aspect at 51.79 ± 5.97μm and thickest at the superior-nasal aspect at 56.07 ± 5.70μm. In Group B, CCT was 465.11± 42.28μm, and the ET was the thinnest at the inferior-temporal aspect at 50.63 ± 5.52μm and thickest at the superior aspect at 56.80 ± 6.39μm. When evaluating CT measurements, ICC was above 0.86 and 0.83 for Group A and Group B respectively. When evaluating ET measurements, ICC was above 0.82 for both groups. CXL had no statistically significant impact on the repeatability of measurements.<h4>Conclusions</h4>AS-OCT provides repeatable CT and ET measurements in the central and peripheral cornea in patients with keratoconus. Repeatability is not affected by a history of CXL.Ye LiAkilesh GokulCharles McGheeMohammed ZiaeiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0248350 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ye Li Akilesh Gokul Charles McGhee Mohammed Ziaei Repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus.
description	<h4>Purpose</h4>To investigate the repeatability in corneal thickness (CT) and epithelial thickness (ET) measurements using spectral domain anterior segment optical coherence tomography (AS-OCT, REVO NX, Optopol) in keratoconus, and examine the effect of corneal crosslinking (CXL) on repeatability.<h4>Methods</h4>A cross-sectional study of 259 eyes of 212 patients with keratoconus attending the corneal disease clinic at a university hospital tertiary referral center were enrolled. Two groups were analysed: eyes with no prior history of CXL (Group A) and eyes with prior CXL (Group B). Repeatability of measurements was assessed using the intraclass correlation coefficient (ICC) and coefficient of variation (CV).<h4>Results</h4>In Group A, central corneal thickness (CCT) was 472.18 ± 45.41μm, and the ET was found to be the thinnest in the inferior-temporal aspect at 51.79 ± 5.97μm and thickest at the superior-nasal aspect at 56.07 ± 5.70μm. In Group B, CCT was 465.11± 42.28μm, and the ET was the thinnest at the inferior-temporal aspect at 50.63 ± 5.52μm and thickest at the superior aspect at 56.80 ± 6.39μm. When evaluating CT measurements, ICC was above 0.86 and 0.83 for Group A and Group B respectively. When evaluating ET measurements, ICC was above 0.82 for both groups. CXL had no statistically significant impact on the repeatability of measurements.<h4>Conclusions</h4>AS-OCT provides repeatable CT and ET measurements in the central and peripheral cornea in patients with keratoconus. Repeatability is not affected by a history of CXL.
format	article
author	Ye Li Akilesh Gokul Charles McGhee Mohammed Ziaei
author_facet	Ye Li Akilesh Gokul Charles McGhee Mohammed Ziaei
author_sort	Ye Li
title	Repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus.
title_short	Repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus.
title_full	Repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus.
title_fullStr	Repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus.
title_full_unstemmed	Repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus.
title_sort	repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/71cc546004ad484aa88d483d38df18dd
work_keys_str_mv	AT yeli repeatabilityofcornealandepithelialthicknessmeasurementswithanteriorsegmentopticalcoherencetomographyinkeratoconus AT akileshgokul repeatabilityofcornealandepithelialthicknessmeasurementswithanteriorsegmentopticalcoherencetomographyinkeratoconus AT charlesmcghee repeatabilityofcornealandepithelialthicknessmeasurementswithanteriorsegmentopticalcoherencetomographyinkeratoconus AT mohammedziaei repeatabilityofcornealandepithelialthicknessmeasurementswithanteriorsegmentopticalcoherencetomographyinkeratoconus
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Repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus.

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