Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner

Objective. The aim of this investigation was to study the expression of genes encoding cAMP-activated protein kinase catalytic and regulatory A subunits (PRKACA and PRKAR1A) and related proteins such as cAMP-dependent protein kinase inhibitors A and G (PKIA and PKIG), catalytic subunit A of protein...

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Autor principal:	Ratushna Oksana O.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	ern1 knockdown homeobox genes mrna expression glucose deprivation u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/71cc63fbf6204843a273372eb55315ab
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spelling	oai:doaj.org-article:71cc63fbf6204843a273372eb55315ab2021-12-02T17:49:33ZGlucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner1336-032910.2478/enr-2020-0027https://doaj.org/article/71cc63fbf6204843a273372eb55315ab2020-10-01T00:00:00Zhttps://doi.org/10.2478/enr-2020-0027https://doaj.org/toc/1336-0329Objective. The aim of this investigation was to study the expression of genes encoding cAMP-activated protein kinase catalytic and regulatory A subunits (PRKACA and PRKAR1A) and related proteins such as cAMP-dependent protein kinase inhibitors A and G (PKIA and PKIG), catalytic subunit A of protein phosphatase 3 (PPP3CA), A-kinase anchoring protein 12 (AKAP12), and praja ring finger ubiquitin ligase 2 (PJA2) in U87 glioma cells in response to glucose deprivation in both control U87 glioma cells and cells with ERN1 (endoplasmic reticulum to nucleus signaling 1) knockdown, the major pathway of the endoplasmic reticulum stress signaling, for evaluation of possible significance of glucose deprivation in ERN1 dependent regulation of glioma growth.Ratushna Oksana O.Sciendoarticleern1 knockdownhomeobox genesmrna expressionglucose deprivationu87 glioma cellsDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 54, Iss 4, Pp 244-254 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ern1 knockdown homeobox genes mrna expression glucose deprivation u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	ern1 knockdown homeobox genes mrna expression glucose deprivation u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665 Ratushna Oksana O. Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner
description	Objective. The aim of this investigation was to study the expression of genes encoding cAMP-activated protein kinase catalytic and regulatory A subunits (PRKACA and PRKAR1A) and related proteins such as cAMP-dependent protein kinase inhibitors A and G (PKIA and PKIG), catalytic subunit A of protein phosphatase 3 (PPP3CA), A-kinase anchoring protein 12 (AKAP12), and praja ring finger ubiquitin ligase 2 (PJA2) in U87 glioma cells in response to glucose deprivation in both control U87 glioma cells and cells with ERN1 (endoplasmic reticulum to nucleus signaling 1) knockdown, the major pathway of the endoplasmic reticulum stress signaling, for evaluation of possible significance of glucose deprivation in ERN1 dependent regulation of glioma growth.
format	article
author	Ratushna Oksana O.
author_facet	Ratushna Oksana O.
author_sort	Ratushna Oksana O.
title	Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner
title_short	Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner
title_full	Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner
title_fullStr	Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner
title_full_unstemmed	Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner
title_sort	glucose deprivation affects the expression of genes encoding camp-activated protein kinase and related proteins in u87 glioma cells in ern1 dependent manner
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/71cc63fbf6204843a273372eb55315ab
work_keys_str_mv	AT ratushnaoksanao glucosedeprivationaffectstheexpressionofgenesencodingcampactivatedproteinkinaseandrelatedproteinsinu87gliomacellsinern1dependentmanner
_version_	1718379414919577600

Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner

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