Predictors of the chest CT score in COVID-19 patients: a cross-sectional study

Abstract Background Since the COVID-19 outbreak, pulmonary involvement was one of the most significant concerns in assessing patients. In the current study, we evaluated patient’s signs, symptoms, and laboratory data on the first visit to predict the severity of pulmonary involvement and their outco...

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Autores principales:	Niloofar Ayoobi Yazdi, Abdolkarim Haji Ghadery, Seyed Ahmad Seyedalinaghi, Fatemeh Jafari, Sirous Jafari, Malihe Hasannezad, Hamid Emadi Koochak, Mohammadreza Salehi, Seyed Ali Dehghan Manshadi, Mohsen Meidani, Mahboubeh Hajiabdolbaghi, Zahra Ahmadinejad, Hossein Khalili, Mohammad-Mehdi Mehrabinejad, Ladan Abbasian
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	COVID-19 Computed tomography Outcome Recovery Chest CT score Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/71d009c6cc8e47ff87cd9580552fb91b
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spelling	oai:doaj.org-article:71d009c6cc8e47ff87cd9580552fb91b2021-11-21T12:02:06ZPredictors of the chest CT score in COVID-19 patients: a cross-sectional study10.1186/s12985-021-01699-61743-422Xhttps://doaj.org/article/71d009c6cc8e47ff87cd9580552fb91b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12985-021-01699-6https://doaj.org/toc/1743-422XAbstract Background Since the COVID-19 outbreak, pulmonary involvement was one of the most significant concerns in assessing patients. In the current study, we evaluated patient’s signs, symptoms, and laboratory data on the first visit to predict the severity of pulmonary involvement and their outcome regarding their initial findings. Methods All referred patients to the COVID-19 clinic of a tertiary referral university hospital were evaluated from April to August 2020. Four hundred seventy-eight COVID-19 patients with positive real-time reverse-transcriptase-polymerase chain reaction (RT-PCR) or highly suggestive symptoms with computed tomography (CT) imaging results with typical findings of COVID-19 were enrolled in the study. The clinical features, initial laboratory, CT findings, and short-term outcomes (ICU admission, mortality, length of hospitalization, and recovery time) were recorded. In addition, the severity of pulmonary involvement was assessed using a semi-quantitative scoring system (0–25). Results Among 478 participants in this study, 353 (73.6%) were admitted to the hospital, and 42 (8.7%) patients were admitted to the ICU. Myalgia (60.4%), fever (59.4%), and dyspnea (57.9%) were the most common symptoms of participants at the first visit. A review of chest CT scans showed that Ground Glass Opacity (GGO) (58.5%) and consolidation (20.7%) were the most patterns of lung lesions. Among initial clinical and laboratory findings, anosmia (P = 0.01), respiratory rate (RR) with a cut point of 25 (P = 0.001), C-reactive protein (CRP) with a cut point of 90 (P = 0.002), white Blood Cell (WBC) with a cut point of 10,000 (P = 0.009), and SpO2 with a cut point of 93 (P = 0.04) was associated with higher chest CT score. Lung involvement and consolidation lesions on chest CT scans were also associated with a more extended hospitalization and recovery period. Conclusions Initial assessment of COVID-19 patients, including symptoms, vital signs, and routine laboratory tests, can predict the severity of lung involvement and unfavorable outcomes.Niloofar Ayoobi YazdiAbdolkarim Haji GhaderySeyed Ahmad SeyedalinaghiFatemeh JafariSirous JafariMalihe HasannezadHamid Emadi KoochakMohammadreza SalehiSeyed Ali Dehghan ManshadiMohsen MeidaniMahboubeh HajiabdolbaghiZahra AhmadinejadHossein KhaliliMohammad-Mehdi MehrabinejadLadan AbbasianBMCarticleCOVID-19Computed tomographyOutcomeRecoveryChest CT scoreInfectious and parasitic diseasesRC109-216ENVirology Journal, Vol 18, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Computed tomography Outcome Recovery Chest CT score Infectious and parasitic diseases RC109-216
spellingShingle	COVID-19 Computed tomography Outcome Recovery Chest CT score Infectious and parasitic diseases RC109-216 Niloofar Ayoobi Yazdi Abdolkarim Haji Ghadery Seyed Ahmad Seyedalinaghi Fatemeh Jafari Sirous Jafari Malihe Hasannezad Hamid Emadi Koochak Mohammadreza Salehi Seyed Ali Dehghan Manshadi Mohsen Meidani Mahboubeh Hajiabdolbaghi Zahra Ahmadinejad Hossein Khalili Mohammad-Mehdi Mehrabinejad Ladan Abbasian Predictors of the chest CT score in COVID-19 patients: a cross-sectional study
description	Abstract Background Since the COVID-19 outbreak, pulmonary involvement was one of the most significant concerns in assessing patients. In the current study, we evaluated patient’s signs, symptoms, and laboratory data on the first visit to predict the severity of pulmonary involvement and their outcome regarding their initial findings. Methods All referred patients to the COVID-19 clinic of a tertiary referral university hospital were evaluated from April to August 2020. Four hundred seventy-eight COVID-19 patients with positive real-time reverse-transcriptase-polymerase chain reaction (RT-PCR) or highly suggestive symptoms with computed tomography (CT) imaging results with typical findings of COVID-19 were enrolled in the study. The clinical features, initial laboratory, CT findings, and short-term outcomes (ICU admission, mortality, length of hospitalization, and recovery time) were recorded. In addition, the severity of pulmonary involvement was assessed using a semi-quantitative scoring system (0–25). Results Among 478 participants in this study, 353 (73.6%) were admitted to the hospital, and 42 (8.7%) patients were admitted to the ICU. Myalgia (60.4%), fever (59.4%), and dyspnea (57.9%) were the most common symptoms of participants at the first visit. A review of chest CT scans showed that Ground Glass Opacity (GGO) (58.5%) and consolidation (20.7%) were the most patterns of lung lesions. Among initial clinical and laboratory findings, anosmia (P = 0.01), respiratory rate (RR) with a cut point of 25 (P = 0.001), C-reactive protein (CRP) with a cut point of 90 (P = 0.002), white Blood Cell (WBC) with a cut point of 10,000 (P = 0.009), and SpO2 with a cut point of 93 (P = 0.04) was associated with higher chest CT score. Lung involvement and consolidation lesions on chest CT scans were also associated with a more extended hospitalization and recovery period. Conclusions Initial assessment of COVID-19 patients, including symptoms, vital signs, and routine laboratory tests, can predict the severity of lung involvement and unfavorable outcomes.
format	article
author	Niloofar Ayoobi Yazdi Abdolkarim Haji Ghadery Seyed Ahmad Seyedalinaghi Fatemeh Jafari Sirous Jafari Malihe Hasannezad Hamid Emadi Koochak Mohammadreza Salehi Seyed Ali Dehghan Manshadi Mohsen Meidani Mahboubeh Hajiabdolbaghi Zahra Ahmadinejad Hossein Khalili Mohammad-Mehdi Mehrabinejad Ladan Abbasian
author_facet	Niloofar Ayoobi Yazdi Abdolkarim Haji Ghadery Seyed Ahmad Seyedalinaghi Fatemeh Jafari Sirous Jafari Malihe Hasannezad Hamid Emadi Koochak Mohammadreza Salehi Seyed Ali Dehghan Manshadi Mohsen Meidani Mahboubeh Hajiabdolbaghi Zahra Ahmadinejad Hossein Khalili Mohammad-Mehdi Mehrabinejad Ladan Abbasian
author_sort	Niloofar Ayoobi Yazdi
title	Predictors of the chest CT score in COVID-19 patients: a cross-sectional study
title_short	Predictors of the chest CT score in COVID-19 patients: a cross-sectional study
title_full	Predictors of the chest CT score in COVID-19 patients: a cross-sectional study
title_fullStr	Predictors of the chest CT score in COVID-19 patients: a cross-sectional study
title_full_unstemmed	Predictors of the chest CT score in COVID-19 patients: a cross-sectional study
title_sort	predictors of the chest ct score in covid-19 patients: a cross-sectional study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/71d009c6cc8e47ff87cd9580552fb91b
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Predictors of the chest CT score in COVID-19 patients: a cross-sectional study

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