Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin

Zeeshan Ahmad Khan,1– 3 Paul Jung-Soo Hong,4,* Christina Hayoung Lee,5,* Yonggeun Hong1– 3,6,7 1Department of Physical Therapy, College of Healthcare Medical Science & Engineering, Inje University, Gimhae, Gyeong-nam, 50834, Korea; 2Biohealth Products Research Center (BPR...

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Autores principales:	Khan ZA, Hong PJS, Lee CH, Hong Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	tryptophan melatonin electrochemical sensors voltammetry optical Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/71d18ed1b8c9444bb826c42172f555cf
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spelling	oai:doaj.org-article:71d18ed1b8c9444bb826c42172f555cf2021-12-02T19:15:35ZRecent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin1178-2013https://doaj.org/article/71d18ed1b8c9444bb826c42172f555cf2021-10-01T00:00:00Zhttps://www.dovepress.com/recent-advances-in-electrochemical-and-optical-sensors-for-detecting-t-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Zeeshan Ahmad Khan,1– 3 Paul Jung-Soo Hong,4,* Christina Hayoung Lee,5,* Yonggeun Hong1– 3,6,7 1Department of Physical Therapy, College of Healthcare Medical Science & Engineering, Inje University, Gimhae, Gyeong-nam, 50834, Korea; 2Biohealth Products Research Center (BPRC), Inje University, Gimhae, Gyeong-nam, 50834, Korea; 3Ubiquitous Healthcare & Anti-Aging Research Center (u-HARC), Inje University, Gimhae, Gyeong-nam, 50834, Korea; 4Department of Chemistry, Newton South High School, Newton, MA, 02459, USA; 5Department of Biology, College of Arts and Sciences, Vanderbilt University, Nashville, TN, 37212, USA; 6Department of Rehabilitation Science, Graduate School of Inje University, Gimhae, Gyeong-nam, 50834, Korea; 7Department of Medicine, Division of Hematology/Oncology, Harvard Medical School-Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA*These authors contributed equally to this workCorrespondence: Yonggeun HongDepartment of Rehabilitation Science, Graduate School of Inje University, 197 Inje-ro, Gimhae, Gyeong-nam, 50834, KoreaTel +82-55-320-3681Fax +82-55-329-1678Email yonghong@inje.ac.krAbstract: Tryptophan and melatonin are pleiotropic molecules, each capable of influencing several cellular, biochemical, and physiological responses. Therefore, sensitive detection of tryptophan and melatonin in pharmaceutical and human samples is crucial for human well-being. Mass spectrometry, high-performance liquid chromatography, and capillary electrophoresis are common methods for both tryptophan and melatonin analysis; however, these methods require copious amounts of time, money, and manpower. Novel electrochemical and optical detection tools have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. Recently, researchers have designed sensitive and selective electrochemical and optical platforms by using new surface modifications, microfabrication techniques, and the decoration of diverse nanomaterials with unique properties for the detection of tryptophan and melatonin. However, there is a scarcity of review articles addressing the recent developments in the electrochemical and optical detection of tryptophan and melatonin. Here, we provide a critical and objective review of high-sensitivity tryptophan and melatonin sensors that have been developed over the past six years (2015 onwards). We review the principles, performance, and limitations of these sensors. We also address critical aspects of sensitivity and selectivity, limit and range of detection, fabrication process and time, durability, and biocompatibility. Finally, we discuss challenges related to tryptophan and melatonin detection and present future outlooks.Keywords: tryptophan, melatonin, electrochemical, sensors, voltammetry, opticalKhan ZAHong PJSLee CHHong YDove Medical PressarticletryptophanmelatoninelectrochemicalsensorsvoltammetryopticalMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 6861-6888 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tryptophan melatonin electrochemical sensors voltammetry optical Medicine (General) R5-920
spellingShingle	tryptophan melatonin electrochemical sensors voltammetry optical Medicine (General) R5-920 Khan ZA Hong PJS Lee CH Hong Y Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin
description	Zeeshan Ahmad Khan,1– 3 Paul Jung-Soo Hong,4,* Christina Hayoung Lee,5,* Yonggeun Hong1– 3,6,7 1Department of Physical Therapy, College of Healthcare Medical Science & Engineering, Inje University, Gimhae, Gyeong-nam, 50834, Korea; 2Biohealth Products Research Center (BPRC), Inje University, Gimhae, Gyeong-nam, 50834, Korea; 3Ubiquitous Healthcare & Anti-Aging Research Center (u-HARC), Inje University, Gimhae, Gyeong-nam, 50834, Korea; 4Department of Chemistry, Newton South High School, Newton, MA, 02459, USA; 5Department of Biology, College of Arts and Sciences, Vanderbilt University, Nashville, TN, 37212, USA; 6Department of Rehabilitation Science, Graduate School of Inje University, Gimhae, Gyeong-nam, 50834, Korea; 7Department of Medicine, Division of Hematology/Oncology, Harvard Medical School-Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA*These authors contributed equally to this workCorrespondence: Yonggeun HongDepartment of Rehabilitation Science, Graduate School of Inje University, 197 Inje-ro, Gimhae, Gyeong-nam, 50834, KoreaTel +82-55-320-3681Fax +82-55-329-1678Email yonghong@inje.ac.krAbstract: Tryptophan and melatonin are pleiotropic molecules, each capable of influencing several cellular, biochemical, and physiological responses. Therefore, sensitive detection of tryptophan and melatonin in pharmaceutical and human samples is crucial for human well-being. Mass spectrometry, high-performance liquid chromatography, and capillary electrophoresis are common methods for both tryptophan and melatonin analysis; however, these methods require copious amounts of time, money, and manpower. Novel electrochemical and optical detection tools have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. Recently, researchers have designed sensitive and selective electrochemical and optical platforms by using new surface modifications, microfabrication techniques, and the decoration of diverse nanomaterials with unique properties for the detection of tryptophan and melatonin. However, there is a scarcity of review articles addressing the recent developments in the electrochemical and optical detection of tryptophan and melatonin. Here, we provide a critical and objective review of high-sensitivity tryptophan and melatonin sensors that have been developed over the past six years (2015 onwards). We review the principles, performance, and limitations of these sensors. We also address critical aspects of sensitivity and selectivity, limit and range of detection, fabrication process and time, durability, and biocompatibility. Finally, we discuss challenges related to tryptophan and melatonin detection and present future outlooks.Keywords: tryptophan, melatonin, electrochemical, sensors, voltammetry, optical
format	article
author	Khan ZA Hong PJS Lee CH Hong Y
author_facet	Khan ZA Hong PJS Lee CH Hong Y
author_sort	Khan ZA
title	Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin
title_short	Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin
title_full	Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin
title_fullStr	Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin
title_full_unstemmed	Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin
title_sort	recent advances in electrochemical and optical sensors for detecting tryptophan and melatonin
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/71d18ed1b8c9444bb826c42172f555cf
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_version_	1718376977569677312

Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin

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