Worldwide spread of Dengue virus type 1.

<h4>Background</h4>DENV-1 is one of the four viral serotypes that causes Dengue, the most common mosquito-borne viral disease of humans. The prevalence of these viruses has grown in recent decades and is now present in more than 100 countries. Limited studies document the spread of DENV-...

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Autores principales:	Christian Julián Villabona-Arenas, Paolo Marinho de Andrade Zanotto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/71d1ce0968be49fdb7a9db76453a293c
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spelling	oai:doaj.org-article:71d1ce0968be49fdb7a9db76453a293c2021-11-18T07:46:02ZWorldwide spread of Dengue virus type 1.1932-620310.1371/journal.pone.0062649https://doaj.org/article/71d1ce0968be49fdb7a9db76453a293c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23675416/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>DENV-1 is one of the four viral serotypes that causes Dengue, the most common mosquito-borne viral disease of humans. The prevalence of these viruses has grown in recent decades and is now present in more than 100 countries. Limited studies document the spread of DENV-1 over the world despite its importance for human health.<h4>Methodology/principal findings</h4>We used representative DENV-1 envelope gene sequences to unravel the dynamics of viral diffusion under a Bayesian phylogeographic approach. Data included strains from 45 distinct geographic locations isolated from 1944 to 2009. The estimated mean rate of nucleotide substitution was 6.56 × 10⁻⁴ substitutions/site/year. The larger genotypes (I, IV and V) had a distinctive phylogenetic structure and since 1990 they experienced effective population size oscillations. Thailand and Indonesia represented the main sources of strains for neighboring countries. Besides, Asia broadcast lineages into the Americas and the Pacific region that diverged in isolation. Also, a transmission network analysis revealed the pivotal role of Indochina in the global diffusion of DENV-1 and of the Caribbean in the diffusion over the Americas.<h4>Conclusions/significance</h4>The study summarizes the spatiotemporal DENV-1 worldwide spread that may help disease control.Christian Julián Villabona-ArenasPaolo Marinho de Andrade ZanottoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e62649 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian Julián Villabona-Arenas Paolo Marinho de Andrade Zanotto Worldwide spread of Dengue virus type 1.
description	<h4>Background</h4>DENV-1 is one of the four viral serotypes that causes Dengue, the most common mosquito-borne viral disease of humans. The prevalence of these viruses has grown in recent decades and is now present in more than 100 countries. Limited studies document the spread of DENV-1 over the world despite its importance for human health.<h4>Methodology/principal findings</h4>We used representative DENV-1 envelope gene sequences to unravel the dynamics of viral diffusion under a Bayesian phylogeographic approach. Data included strains from 45 distinct geographic locations isolated from 1944 to 2009. The estimated mean rate of nucleotide substitution was 6.56 × 10⁻⁴ substitutions/site/year. The larger genotypes (I, IV and V) had a distinctive phylogenetic structure and since 1990 they experienced effective population size oscillations. Thailand and Indonesia represented the main sources of strains for neighboring countries. Besides, Asia broadcast lineages into the Americas and the Pacific region that diverged in isolation. Also, a transmission network analysis revealed the pivotal role of Indochina in the global diffusion of DENV-1 and of the Caribbean in the diffusion over the Americas.<h4>Conclusions/significance</h4>The study summarizes the spatiotemporal DENV-1 worldwide spread that may help disease control.
format	article
author	Christian Julián Villabona-Arenas Paolo Marinho de Andrade Zanotto
author_facet	Christian Julián Villabona-Arenas Paolo Marinho de Andrade Zanotto
author_sort	Christian Julián Villabona-Arenas
title	Worldwide spread of Dengue virus type 1.
title_short	Worldwide spread of Dengue virus type 1.
title_full	Worldwide spread of Dengue virus type 1.
title_fullStr	Worldwide spread of Dengue virus type 1.
title_full_unstemmed	Worldwide spread of Dengue virus type 1.
title_sort	worldwide spread of dengue virus type 1.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/71d1ce0968be49fdb7a9db76453a293c
work_keys_str_mv	AT christianjulianvillabonaarenas worldwidespreadofdenguevirustype1 AT paolomarinhodeandradezanotto worldwidespreadofdenguevirustype1
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Worldwide spread of Dengue virus type 1.

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