Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model
Abstract The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the defining global health emergency of this century. GC-376 is a Mpro inhibitor with antiviral activity against SARS-CoV-2 in vitro. Using the K18-hACE2 mouse model, the in vivo antiviral ef...
Guardado en:
Autores principales: | C. Joaquín Cáceres, Stivalis Cardenas-Garcia, Silvia Carnaccini, Brittany Seibert, Daniela S. Rajao, Jun Wang, Daniel R. Perez |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/71d2e993765649be8e0f6b0bf79c99a9 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
por: Ronit Rosenfeld, et al.
Publicado: (2021) -
SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains
por: Peter Radvak, et al.
Publicado: (2021) -
The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice
por: Rafael Bayarri-Olmos, et al.
Publicado: (2021) -
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
por: Lifeng Fu, et al.
Publicado: (2020) -
Attractive and repulsive residue fragments at the interface of SARS-CoV-2 and hACE2
por: Jorge H. Rodriguez
Publicado: (2021)