Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering

Hadi Hajiali1, Shapour Shahgasempour1, M Reza Naimi-Jamal2, Habibullah Peirovi11Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences; 2Department of Chemistry, Iran University of Science and Technology, Tehran, IranBackground and methods: In this study,...

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Autores principales:	Peirovi H, Naimi-Jamal MR, Shahgasempour S, Hajiali H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/71d353e73bdd41b8b434d9b5223a8c90
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spelling	oai:doaj.org-article:71d353e73bdd41b8b434d9b5223a8c902021-12-02T00:40:24ZElectrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering1176-91141178-2013https://doaj.org/article/71d353e73bdd41b8b434d9b5223a8c902011-09-01T00:00:00Zhttp://www.dovepress.com/electrospun-pgagelatin-nanofibrous-scaffolds-and-their-potential-appli-a8369https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hadi Hajiali1, Shapour Shahgasempour1, M Reza Naimi-Jamal2, Habibullah Peirovi11Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences; 2Department of Chemistry, Iran University of Science and Technology, Tehran, IranBackground and methods: In this study, gelatin was blended with polyglycolic acid (PGA) at different ratios (0, 10, 30, and 50 wt%) and electrospun. The morphology and structure of the scaffolds were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and differential scanning calorimetry. The mechanical properties were also measured by the tensile test. Furthermore, for biocompatibility assessment, human umbilical vein endothelial cells and human umbilical artery smooth muscle cells were cultured on these scaffolds, and cell attachment and viability were evaluated.Results: PGA with 10 wt% gelatin enhanced the endothelial cells whilst PGA with 30 wt% gelatin increased smooth muscle cell adhesion, penetration, and viability compared with the other scaffold blends. Additionally, with the increase in gelatin content, the mechanical properties of the scaffolds were improved due to interaction between PGA and gelatin, as revealed by Fourier transform infrared spectroscopy and differential scanning calorimetry.Conclusion: Incorporation of gelatin improves the biological and mechanical properties of PGA, making promising scaffolds for vascular tissue engineering.Keywords: polyglycolic acid, gelatin, nanofiber, vascular tissue engineering, biocompatible scaffold&nbsp;Peirovi HNaimi-Jamal MRShahgasempour SHajiali HDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 2133-2141 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Peirovi H Naimi-Jamal MR Shahgasempour S Hajiali H Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering
description	Hadi Hajiali1, Shapour Shahgasempour1, M Reza Naimi-Jamal2, Habibullah Peirovi11Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences; 2Department of Chemistry, Iran University of Science and Technology, Tehran, IranBackground and methods: In this study, gelatin was blended with polyglycolic acid (PGA) at different ratios (0, 10, 30, and 50 wt%) and electrospun. The morphology and structure of the scaffolds were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and differential scanning calorimetry. The mechanical properties were also measured by the tensile test. Furthermore, for biocompatibility assessment, human umbilical vein endothelial cells and human umbilical artery smooth muscle cells were cultured on these scaffolds, and cell attachment and viability were evaluated.Results: PGA with 10 wt% gelatin enhanced the endothelial cells whilst PGA with 30 wt% gelatin increased smooth muscle cell adhesion, penetration, and viability compared with the other scaffold blends. Additionally, with the increase in gelatin content, the mechanical properties of the scaffolds were improved due to interaction between PGA and gelatin, as revealed by Fourier transform infrared spectroscopy and differential scanning calorimetry.Conclusion: Incorporation of gelatin improves the biological and mechanical properties of PGA, making promising scaffolds for vascular tissue engineering.Keywords: polyglycolic acid, gelatin, nanofiber, vascular tissue engineering, biocompatible scaffold&nbsp;
format	article
author	Peirovi H Naimi-Jamal MR Shahgasempour S Hajiali H
author_facet	Peirovi H Naimi-Jamal MR Shahgasempour S Hajiali H
author_sort	Peirovi H
title	Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering
title_short	Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering
title_full	Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering
title_fullStr	Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering
title_full_unstemmed	Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering
title_sort	electrospun pga/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/71d353e73bdd41b8b434d9b5223a8c90
work_keys_str_mv	AT peirovih electrospunpgagelatinnanofibrousscaffoldsandtheirpotentialapplicationinvasculartissueengineering AT naimijamalmr electrospunpgagelatinnanofibrousscaffoldsandtheirpotentialapplicationinvasculartissueengineering AT shahgasempours electrospunpgagelatinnanofibrousscaffoldsandtheirpotentialapplicationinvasculartissueengineering AT hajialih electrospunpgagelatinnanofibrousscaffoldsandtheirpotentialapplicationinvasculartissueengineering
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Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering

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