Risk Factors and a Nomogram for Predicting Intracranial Hemorrhage in Stroke Patients Undergoing Thrombolysis

Zheren Zhou,1,* Xiaoyan Yin,2,3,* Qiuwen Niu,2 Simin Liang,2,4 Chunying Mu,2 Yurong Zhang2 1University Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong Un...

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Autores principales:	Zhou Z, Yin X, Niu Q, Liang S, Mu C, Zhang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	stroke intracranialhemorrhage thrombolysis nomogram prognosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/71d3a7f28b8c4f4286491a1af45c03da
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spelling	oai:doaj.org-article:71d3a7f28b8c4f4286491a1af45c03da2021-12-02T09:19:51ZRisk Factors and a Nomogram for Predicting Intracranial Hemorrhage in Stroke Patients Undergoing Thrombolysis1178-2021https://doaj.org/article/71d3a7f28b8c4f4286491a1af45c03da2020-05-01T00:00:00Zhttps://www.dovepress.com/risk-factors-and-a-nomogram-for-predicting-intracranial-hemorrhage-in--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Zheren Zhou,1,* Xiaoyan Yin,2,3,* Qiuwen Niu,2 Simin Liang,2,4 Chunying Mu,2 Yurong Zhang2 1University Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Neurology, Wuqi People’s Hospital, Yan’an, Shaanxi, People’s Republic of China; 4Department of Neurology, The First Affiliated Hospital of Xi’an Medical College, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yurong Zhang Email zhangyurong72@mail.xjtu.edu.cnPurpose: Identifying stroke patients at risk of postthrombolysis intracranial hemorrhage (ICH) in the clinical setting is essential. We aimed to develop and evaluate a nomogram for predicting the probability of ICH in acute ischemic stroke patients undergoing thrombolysis.Patients and Methods: A retrospective observational study was conducted using data from 345 patients at a single center. The patients were randomly dichotomized into training (2/3; n=233) and validation (1/3; n=112) sets. A prediction model was developed by using a multivariable logistic regression analysis.Results: The nomogram comprised three variables: the presence of atrial fibrillation (odds ratio [OR]: 4.92, 95% confidence interval [CI]: 2.09– 11.57), the National Institutes of Health Stroke Scale (NIHSS) score (OR: 1.11, 95% CI: 1.04– 1.18) and the glucose level on admission (OR: 1.27, 95% CI: 1.08– 1.50). The areas under the receiver operating characteristic curve of the nomogram for the training and validation sets were 0.828 (0.753– 0.903) and 0.801 (0.690– 0.911), respectively. The Hosmer–Lemeshow test revealed good calibration in both the training and validation sets (P = 0.509 and P = 0.342, respectively). The calibration plot also demonstrated good agreement. A decision curve analysis demonstrated that the nomogram was clinically useful.Conclusion: We developed an easy-to-use nomogram model to predict ICH, and the nomogram may provide risk assessments for subsequent treatment in stroke patients undergoing thrombolysis.Keywords: stroke, intracranial hemorrhage, thrombolysis, nomogram, prognosisZhou ZYin XNiu QLiang SMu CZhang YDove Medical PressarticlestrokeintracranialhemorrhagethrombolysisnomogramprognosisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1189-1197 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke intracranialhemorrhage thrombolysis nomogram prognosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	stroke intracranialhemorrhage thrombolysis nomogram prognosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhou Z Yin X Niu Q Liang S Mu C Zhang Y Risk Factors and a Nomogram for Predicting Intracranial Hemorrhage in Stroke Patients Undergoing Thrombolysis
description	Zheren Zhou,1,* Xiaoyan Yin,2,3,* Qiuwen Niu,2 Simin Liang,2,4 Chunying Mu,2 Yurong Zhang2 1University Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Neurology, Wuqi People’s Hospital, Yan’an, Shaanxi, People’s Republic of China; 4Department of Neurology, The First Affiliated Hospital of Xi’an Medical College, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yurong Zhang Email zhangyurong72@mail.xjtu.edu.cnPurpose: Identifying stroke patients at risk of postthrombolysis intracranial hemorrhage (ICH) in the clinical setting is essential. We aimed to develop and evaluate a nomogram for predicting the probability of ICH in acute ischemic stroke patients undergoing thrombolysis.Patients and Methods: A retrospective observational study was conducted using data from 345 patients at a single center. The patients were randomly dichotomized into training (2/3; n=233) and validation (1/3; n=112) sets. A prediction model was developed by using a multivariable logistic regression analysis.Results: The nomogram comprised three variables: the presence of atrial fibrillation (odds ratio [OR]: 4.92, 95% confidence interval [CI]: 2.09– 11.57), the National Institutes of Health Stroke Scale (NIHSS) score (OR: 1.11, 95% CI: 1.04– 1.18) and the glucose level on admission (OR: 1.27, 95% CI: 1.08– 1.50). The areas under the receiver operating characteristic curve of the nomogram for the training and validation sets were 0.828 (0.753– 0.903) and 0.801 (0.690– 0.911), respectively. The Hosmer–Lemeshow test revealed good calibration in both the training and validation sets (P = 0.509 and P = 0.342, respectively). The calibration plot also demonstrated good agreement. A decision curve analysis demonstrated that the nomogram was clinically useful.Conclusion: We developed an easy-to-use nomogram model to predict ICH, and the nomogram may provide risk assessments for subsequent treatment in stroke patients undergoing thrombolysis.Keywords: stroke, intracranial hemorrhage, thrombolysis, nomogram, prognosis
format	article
author	Zhou Z Yin X Niu Q Liang S Mu C Zhang Y
author_facet	Zhou Z Yin X Niu Q Liang S Mu C Zhang Y
author_sort	Zhou Z
title	Risk Factors and a Nomogram for Predicting Intracranial Hemorrhage in Stroke Patients Undergoing Thrombolysis
title_short	Risk Factors and a Nomogram for Predicting Intracranial Hemorrhage in Stroke Patients Undergoing Thrombolysis
title_full	Risk Factors and a Nomogram for Predicting Intracranial Hemorrhage in Stroke Patients Undergoing Thrombolysis
title_fullStr	Risk Factors and a Nomogram for Predicting Intracranial Hemorrhage in Stroke Patients Undergoing Thrombolysis
title_full_unstemmed	Risk Factors and a Nomogram for Predicting Intracranial Hemorrhage in Stroke Patients Undergoing Thrombolysis
title_sort	risk factors and a nomogram for predicting intracranial hemorrhage in stroke patients undergoing thrombolysis
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/71d3a7f28b8c4f4286491a1af45c03da
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Risk Factors and a Nomogram for Predicting Intracranial Hemorrhage in Stroke Patients Undergoing Thrombolysis

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