Acute fat loss does not affect bone mass

Abstract Obesity has previously been thought to protect bone since high body weight and body mass index are associated with high bone mass. However, some more recent studies suggest that increased adiposity negatively impacts bone mass. Here, we aimed to test whether acute loss of adipose tissue, vi...

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Autores principales:	Marie K. Lagerquist, Karin L. Gustafsson, Petra Henning, Helen Farman, Jianyao Wu, Klara Sjögren, Antti Koskela, Juha Tuukkanen, Claes Ohlsson, Ingrid Wernstedt Asterholm, Louise Grahnemo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/71d40cd8466842cca13db51afcfedbdf
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spelling	oai:doaj.org-article:71d40cd8466842cca13db51afcfedbdf2021-12-02T15:22:57ZAcute fat loss does not affect bone mass10.1038/s41598-021-93450-y2045-2322https://doaj.org/article/71d40cd8466842cca13db51afcfedbdf2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93450-yhttps://doaj.org/toc/2045-2322Abstract Obesity has previously been thought to protect bone since high body weight and body mass index are associated with high bone mass. However, some more recent studies suggest that increased adiposity negatively impacts bone mass. Here, we aimed to test whether acute loss of adipose tissue, via adipocyte apoptosis, alters bone mass in age-related obese mice. Adipocyte apoptosis was induced in obese male FAT-ATTAC mice through AP20187 dimerizer-mediated activation of caspase 8 selectively in adipocytes. In a short-term experiment, dimerizer was administered to 5.5 month-old mice that were terminated 2 weeks later. At termination, the total fat mass weighed 58% less in dimerizer-treated mice compared with vehicle-treated controls, but bone mass did not differ. To allow for the detection of long-term effects, we used 9-month-old mice that were terminated six weeks after dimerizer administration. In this experiment, the total fat mass weighed less (− 68%) in the dimerizer-treated mice than in the controls, yet neither bone mass nor biomechanical properties differed between groups. Our findings show that adipose tissue loss, despite the reduced mechanical loading, does not affect bone in age-related obese mice. Future studies are needed to test whether adipose tissue loss is beneficial during more severe obesity.Marie K. LagerquistKarin L. GustafssonPetra HenningHelen FarmanJianyao WuKlara SjögrenAntti KoskelaJuha TuukkanenClaes OhlssonIngrid Wernstedt AsterholmLouise GrahnemoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie K. Lagerquist Karin L. Gustafsson Petra Henning Helen Farman Jianyao Wu Klara Sjögren Antti Koskela Juha Tuukkanen Claes Ohlsson Ingrid Wernstedt Asterholm Louise Grahnemo Acute fat loss does not affect bone mass
description	Abstract Obesity has previously been thought to protect bone since high body weight and body mass index are associated with high bone mass. However, some more recent studies suggest that increased adiposity negatively impacts bone mass. Here, we aimed to test whether acute loss of adipose tissue, via adipocyte apoptosis, alters bone mass in age-related obese mice. Adipocyte apoptosis was induced in obese male FAT-ATTAC mice through AP20187 dimerizer-mediated activation of caspase 8 selectively in adipocytes. In a short-term experiment, dimerizer was administered to 5.5 month-old mice that were terminated 2 weeks later. At termination, the total fat mass weighed 58% less in dimerizer-treated mice compared with vehicle-treated controls, but bone mass did not differ. To allow for the detection of long-term effects, we used 9-month-old mice that were terminated six weeks after dimerizer administration. In this experiment, the total fat mass weighed less (− 68%) in the dimerizer-treated mice than in the controls, yet neither bone mass nor biomechanical properties differed between groups. Our findings show that adipose tissue loss, despite the reduced mechanical loading, does not affect bone in age-related obese mice. Future studies are needed to test whether adipose tissue loss is beneficial during more severe obesity.
format	article
author	Marie K. Lagerquist Karin L. Gustafsson Petra Henning Helen Farman Jianyao Wu Klara Sjögren Antti Koskela Juha Tuukkanen Claes Ohlsson Ingrid Wernstedt Asterholm Louise Grahnemo
author_facet	Marie K. Lagerquist Karin L. Gustafsson Petra Henning Helen Farman Jianyao Wu Klara Sjögren Antti Koskela Juha Tuukkanen Claes Ohlsson Ingrid Wernstedt Asterholm Louise Grahnemo
author_sort	Marie K. Lagerquist
title	Acute fat loss does not affect bone mass
title_short	Acute fat loss does not affect bone mass
title_full	Acute fat loss does not affect bone mass
title_fullStr	Acute fat loss does not affect bone mass
title_full_unstemmed	Acute fat loss does not affect bone mass
title_sort	acute fat loss does not affect bone mass
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/71d40cd8466842cca13db51afcfedbdf
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Acute fat loss does not affect bone mass

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