Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα

The transcription factor retinoid X receptor-alpha (RXRα) can also form homotetramers. Here the authors show that the anti-cancer agent K-80003 selectively inhibits the nongenomic action of N-terminally-cleaved RXRα in tumour cells by stabilizing its tetramerization but not that of full-length RXRα....

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Autores principales:	Liqun Chen, Alexander E. Aleshin, Gulimiran Alitongbieke, Yuqi Zhou, Xindao Zhang, Xiaohong Ye, Mengjie Hu, Gaoang Ren, Ziwen Chen, Yue Ma, Duo Zhang, Shuai Liu, Weiwei Gao, Lijun Cai, Lingjuan Wu, Zhiping Zeng, Fuquan Jiang, Jie Liu, Hu Zhou, Gregory Cadwell, Robert C. Liddington, Ying Su, Xiao-kun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71d7bb2769b44bccb25ef396c7774a55
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spelling	oai:doaj.org-article:71d7bb2769b44bccb25ef396c7774a552021-12-02T17:06:10ZModulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα10.1038/ncomms160662041-1723https://doaj.org/article/71d7bb2769b44bccb25ef396c7774a552017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16066https://doaj.org/toc/2041-1723The transcription factor retinoid X receptor-alpha (RXRα) can also form homotetramers. Here the authors show that the anti-cancer agent K-80003 selectively inhibits the nongenomic action of N-terminally-cleaved RXRα in tumour cells by stabilizing its tetramerization but not that of full-length RXRα.Liqun ChenAlexander E. AleshinGulimiran AlitongbiekeYuqi ZhouXindao ZhangXiaohong YeMengjie HuGaoang RenZiwen ChenYue MaDuo ZhangShuai LiuWeiwei GaoLijun CaiLingjuan WuZhiping ZengFuquan JiangJie LiuHu ZhouGregory CadwellRobert C. LiddingtonYing SuXiao-kun ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liqun Chen Alexander E. Aleshin Gulimiran Alitongbieke Yuqi Zhou Xindao Zhang Xiaohong Ye Mengjie Hu Gaoang Ren Ziwen Chen Yue Ma Duo Zhang Shuai Liu Weiwei Gao Lijun Cai Lingjuan Wu Zhiping Zeng Fuquan Jiang Jie Liu Hu Zhou Gregory Cadwell Robert C. Liddington Ying Su Xiao-kun Zhang Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα
description	The transcription factor retinoid X receptor-alpha (RXRα) can also form homotetramers. Here the authors show that the anti-cancer agent K-80003 selectively inhibits the nongenomic action of N-terminally-cleaved RXRα in tumour cells by stabilizing its tetramerization but not that of full-length RXRα.
format	article
author	Liqun Chen Alexander E. Aleshin Gulimiran Alitongbieke Yuqi Zhou Xindao Zhang Xiaohong Ye Mengjie Hu Gaoang Ren Ziwen Chen Yue Ma Duo Zhang Shuai Liu Weiwei Gao Lijun Cai Lingjuan Wu Zhiping Zeng Fuquan Jiang Jie Liu Hu Zhou Gregory Cadwell Robert C. Liddington Ying Su Xiao-kun Zhang
author_facet	Liqun Chen Alexander E. Aleshin Gulimiran Alitongbieke Yuqi Zhou Xindao Zhang Xiaohong Ye Mengjie Hu Gaoang Ren Ziwen Chen Yue Ma Duo Zhang Shuai Liu Weiwei Gao Lijun Cai Lingjuan Wu Zhiping Zeng Fuquan Jiang Jie Liu Hu Zhou Gregory Cadwell Robert C. Liddington Ying Su Xiao-kun Zhang
author_sort	Liqun Chen
title	Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα
title_short	Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα
title_full	Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα
title_fullStr	Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα
title_full_unstemmed	Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα
title_sort	modulation of nongenomic activation of pi3k signalling by tetramerization of n-terminally-cleaved rxrα
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/71d7bb2769b44bccb25ef396c7774a55
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Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα

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