Critical role of interferons in gastrointestinal injury repair

Critical role of interferons in gastrointestinal injury repair

Despite being prevalent yet well studied, ulcerative colitis still has poorly characterized pathophysiology. Here the authors use mouse colitis models to find that type I and III interferon (IFN) both contribute to ameliorating the disease, with IFN signaling in either the epithelial or hematopoieti...

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Autores principales: Constance McElrath, Vanessa Espinosa, Jian-Da Lin, Jianya Peng, Raghavendra Sridhar, Orchi Dutta, Hsiang-Chi Tseng, Sergey V. Smirnov, Heidi Risman, Marvin J. Sandoval, Viralkumar Davra, Yun-Juan Chang, Brian P. Pollack, Raymond B. Birge, Mark Galan, Amariliz Rivera, Joan E. Durbin, Sergei V. Kotenko
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/71db4af0b0d54c2a94af312d1646e924
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Sumario:Despite being prevalent yet well studied, ulcerative colitis still has poorly characterized pathophysiology. Here the authors use mouse colitis models to find that type I and III interferon (IFN) both contribute to ameliorating the disease, with IFN signaling in either the epithelial or hematopoietic compartment sufficient for this protective effect.

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