Critical role of interferons in gastrointestinal injury repair

Despite being prevalent yet well studied, ulcerative colitis still has poorly characterized pathophysiology. Here the authors use mouse colitis models to find that type I and III interferon (IFN) both contribute to ameliorating the disease, with IFN signaling in either the epithelial or hematopoieti...

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Autores principales:	Constance McElrath, Vanessa Espinosa, Jian-Da Lin, Jianya Peng, Raghavendra Sridhar, Orchi Dutta, Hsiang-Chi Tseng, Sergey V. Smirnov, Heidi Risman, Marvin J. Sandoval, Viralkumar Davra, Yun-Juan Chang, Brian P. Pollack, Raymond B. Birge, Mark Galan, Amariliz Rivera, Joan E. Durbin, Sergei V. Kotenko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71db4af0b0d54c2a94af312d1646e924
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spelling	oai:doaj.org-article:71db4af0b0d54c2a94af312d1646e9242021-12-02T14:35:39ZCritical role of interferons in gastrointestinal injury repair10.1038/s41467-021-22928-02041-1723https://doaj.org/article/71db4af0b0d54c2a94af312d1646e9242021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22928-0https://doaj.org/toc/2041-1723Despite being prevalent yet well studied, ulcerative colitis still has poorly characterized pathophysiology. Here the authors use mouse colitis models to find that type I and III interferon (IFN) both contribute to ameliorating the disease, with IFN signaling in either the epithelial or hematopoietic compartment sufficient for this protective effect.Constance McElrathVanessa EspinosaJian-Da LinJianya PengRaghavendra SridharOrchi DuttaHsiang-Chi TsengSergey V. SmirnovHeidi RismanMarvin J. SandovalViralkumar DavraYun-Juan ChangBrian P. PollackRaymond B. BirgeMark GalanAmariliz RiveraJoan E. DurbinSergei V. KotenkoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Constance McElrath Vanessa Espinosa Jian-Da Lin Jianya Peng Raghavendra Sridhar Orchi Dutta Hsiang-Chi Tseng Sergey V. Smirnov Heidi Risman Marvin J. Sandoval Viralkumar Davra Yun-Juan Chang Brian P. Pollack Raymond B. Birge Mark Galan Amariliz Rivera Joan E. Durbin Sergei V. Kotenko Critical role of interferons in gastrointestinal injury repair
description	Despite being prevalent yet well studied, ulcerative colitis still has poorly characterized pathophysiology. Here the authors use mouse colitis models to find that type I and III interferon (IFN) both contribute to ameliorating the disease, with IFN signaling in either the epithelial or hematopoietic compartment sufficient for this protective effect.
format	article
author	Constance McElrath Vanessa Espinosa Jian-Da Lin Jianya Peng Raghavendra Sridhar Orchi Dutta Hsiang-Chi Tseng Sergey V. Smirnov Heidi Risman Marvin J. Sandoval Viralkumar Davra Yun-Juan Chang Brian P. Pollack Raymond B. Birge Mark Galan Amariliz Rivera Joan E. Durbin Sergei V. Kotenko
author_facet	Constance McElrath Vanessa Espinosa Jian-Da Lin Jianya Peng Raghavendra Sridhar Orchi Dutta Hsiang-Chi Tseng Sergey V. Smirnov Heidi Risman Marvin J. Sandoval Viralkumar Davra Yun-Juan Chang Brian P. Pollack Raymond B. Birge Mark Galan Amariliz Rivera Joan E. Durbin Sergei V. Kotenko
author_sort	Constance McElrath
title	Critical role of interferons in gastrointestinal injury repair
title_short	Critical role of interferons in gastrointestinal injury repair
title_full	Critical role of interferons in gastrointestinal injury repair
title_fullStr	Critical role of interferons in gastrointestinal injury repair
title_full_unstemmed	Critical role of interferons in gastrointestinal injury repair
title_sort	critical role of interferons in gastrointestinal injury repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/71db4af0b0d54c2a94af312d1646e924
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Critical role of interferons in gastrointestinal injury repair

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