Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells

The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells,...

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Autores principales: Angela M. Lager, Olivia G. Corradin, Jared M. Cregg, Matthew S. Elitt, H. Elizabeth Shick, Benjamin L. L. Clayton, Kevin C. Allan, Hannah E. Olsen, Mayur Madhavan, Paul J. Tesar
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/71dbdedc40fa404b962276780906a9a8
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spelling oai:doaj.org-article:71dbdedc40fa404b962276780906a9a82021-12-02T17:33:06ZRapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells10.1038/s41467-018-06102-72041-1723https://doaj.org/article/71dbdedc40fa404b962276780906a9a82018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06102-7https://doaj.org/toc/2041-1723The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells, independent of mouse strain or mutational status.Angela M. LagerOlivia G. CorradinJared M. CreggMatthew S. ElittH. Elizabeth ShickBenjamin L. L. ClaytonKevin C. AllanHannah E. OlsenMayur MadhavanPaul J. TesarNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Angela M. Lager
Olivia G. Corradin
Jared M. Cregg
Matthew S. Elitt
H. Elizabeth Shick
Benjamin L. L. Clayton
Kevin C. Allan
Hannah E. Olsen
Mayur Madhavan
Paul J. Tesar
Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
description The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells, independent of mouse strain or mutational status.
format article
author Angela M. Lager
Olivia G. Corradin
Jared M. Cregg
Matthew S. Elitt
H. Elizabeth Shick
Benjamin L. L. Clayton
Kevin C. Allan
Hannah E. Olsen
Mayur Madhavan
Paul J. Tesar
author_facet Angela M. Lager
Olivia G. Corradin
Jared M. Cregg
Matthew S. Elitt
H. Elizabeth Shick
Benjamin L. L. Clayton
Kevin C. Allan
Hannah E. Olsen
Mayur Madhavan
Paul J. Tesar
author_sort Angela M. Lager
title Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
title_short Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
title_full Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
title_fullStr Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
title_full_unstemmed Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
title_sort rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/71dbdedc40fa404b962276780906a9a8
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