Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells,...
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Nature Portfolio
2018
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oai:doaj.org-article:71dbdedc40fa404b962276780906a9a82021-12-02T17:33:06ZRapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells10.1038/s41467-018-06102-72041-1723https://doaj.org/article/71dbdedc40fa404b962276780906a9a82018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06102-7https://doaj.org/toc/2041-1723The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells, independent of mouse strain or mutational status.Angela M. LagerOlivia G. CorradinJared M. CreggMatthew S. ElittH. Elizabeth ShickBenjamin L. L. ClaytonKevin C. AllanHannah E. OlsenMayur MadhavanPaul J. TesarNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
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Science Q |
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Science Q Angela M. Lager Olivia G. Corradin Jared M. Cregg Matthew S. Elitt H. Elizabeth Shick Benjamin L. L. Clayton Kevin C. Allan Hannah E. Olsen Mayur Madhavan Paul J. Tesar Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells |
description |
The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells, independent of mouse strain or mutational status. |
format |
article |
author |
Angela M. Lager Olivia G. Corradin Jared M. Cregg Matthew S. Elitt H. Elizabeth Shick Benjamin L. L. Clayton Kevin C. Allan Hannah E. Olsen Mayur Madhavan Paul J. Tesar |
author_facet |
Angela M. Lager Olivia G. Corradin Jared M. Cregg Matthew S. Elitt H. Elizabeth Shick Benjamin L. L. Clayton Kevin C. Allan Hannah E. Olsen Mayur Madhavan Paul J. Tesar |
author_sort |
Angela M. Lager |
title |
Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells |
title_short |
Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells |
title_full |
Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells |
title_fullStr |
Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells |
title_full_unstemmed |
Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells |
title_sort |
rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/71dbdedc40fa404b962276780906a9a8 |
work_keys_str_mv |
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1718380067820666880 |