Differential effects of dopamine-directed treatments on cognition

F Gregory Ashby, Vivian V Valentin, Stella S von Meer Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, USA Abstract: Dopamine, a prominent neuromodulator, is implicated in many neuropsychiatric disorders. It has wide-ranging effects on both cortical and...

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Autores principales:	Ashby FG, Valentin VV, von Meer SS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/71dc2fdd5c9a4096b2d5ce6a7bb21734
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spelling	oai:doaj.org-article:71dc2fdd5c9a4096b2d5ce6a7bb217342021-12-02T02:38:29ZDifferential effects of dopamine-directed treatments on cognition1178-2021https://doaj.org/article/71dc2fdd5c9a4096b2d5ce6a7bb217342015-07-01T00:00:00Zhttp://www.dovepress.com/differential-effects-of-dopamine-directed-treatments-on-cognition-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021F Gregory Ashby, Vivian V Valentin, Stella S von Meer Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, USA Abstract: Dopamine, a prominent neuromodulator, is implicated in many neuropsychiatric disorders. It has wide-ranging effects on both cortical and subcortical brain regions and on many types of cognitive tasks that rely on a variety of different learning and memory systems. As neuroscience and behavioral evidence for the existence of multiple memory systems and their corresponding neural networks accumulated, so did the notion that dopamine’s role is markedly different depending on which memory system is engaged. As a result, dopamine-directed treatments will have different effects on different types of cognitive behaviors. To predict what these effects will be, it is critical to understand: which memory system is mediating the behavior; the neural basis of the mediating memory system; the nature of the dopamine projections into that system; and the time course of dopamine after its release into the relevant brain regions. Consideration of these questions leads to different predictions for how changes in brain dopamine levels will affect automatic behaviors and behaviors mediated by declarative, procedural, and perceptual representation memory systems. Keywords: dopamine, cognition, memory systems, learningAshby FGValentin VVvon Meer SSDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 1859-1875 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ashby FG Valentin VV von Meer SS Differential effects of dopamine-directed treatments on cognition
description	F Gregory Ashby, Vivian V Valentin, Stella S von Meer Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, USA Abstract: Dopamine, a prominent neuromodulator, is implicated in many neuropsychiatric disorders. It has wide-ranging effects on both cortical and subcortical brain regions and on many types of cognitive tasks that rely on a variety of different learning and memory systems. As neuroscience and behavioral evidence for the existence of multiple memory systems and their corresponding neural networks accumulated, so did the notion that dopamine’s role is markedly different depending on which memory system is engaged. As a result, dopamine-directed treatments will have different effects on different types of cognitive behaviors. To predict what these effects will be, it is critical to understand: which memory system is mediating the behavior; the neural basis of the mediating memory system; the nature of the dopamine projections into that system; and the time course of dopamine after its release into the relevant brain regions. Consideration of these questions leads to different predictions for how changes in brain dopamine levels will affect automatic behaviors and behaviors mediated by declarative, procedural, and perceptual representation memory systems. Keywords: dopamine, cognition, memory systems, learning
format	article
author	Ashby FG Valentin VV von Meer SS
author_facet	Ashby FG Valentin VV von Meer SS
author_sort	Ashby FG
title	Differential effects of dopamine-directed treatments on cognition
title_short	Differential effects of dopamine-directed treatments on cognition
title_full	Differential effects of dopamine-directed treatments on cognition
title_fullStr	Differential effects of dopamine-directed treatments on cognition
title_full_unstemmed	Differential effects of dopamine-directed treatments on cognition
title_sort	differential effects of dopamine-directed treatments on cognition
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/71dc2fdd5c9a4096b2d5ce6a7bb21734
work_keys_str_mv	AT ashbyfg differentialeffectsofdopaminedirectedtreatmentsoncognition AT valentinvv differentialeffectsofdopaminedirectedtreatmentsoncognition AT vonmeerss differentialeffectsofdopaminedirectedtreatmentsoncognition
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Differential effects of dopamine-directed treatments on cognition

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