Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

Fibrosis is a hallmark of several cardiac pathologies and its underlying mechanisms are still poorly defined. Here the authors show that macrophage hypoxia signaling following transverse aortic constriction in mice suppresses the activation of cardiac fibroblasts by secreting oncostatin M.

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Autores principales:	Hajime Abe, Norihiko Takeda, Takayuki Isagawa, Hiroaki Semba, Satoshi Nishimura, Masaki Suimye Morioka, Yu Nakagama, Tatsuyuki Sato, Katsura Soma, Katsuhiro Koyama, Masaki Wake, Manami Katoh, Masataka Asagiri, Michael L. Neugent, Jung-whan Kim, Christian Stockmann, Tomo Yonezawa, Ryo Inuzuka, Yasushi Hirota, Koji Maemura, Takeshi Yamashita, Kinya Otsu, Ichiro Manabe, Ryozo Nagai, Issei Komuro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71dda70f0fa943e6abde76eae9ef37b9
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spelling	oai:doaj.org-article:71dda70f0fa943e6abde76eae9ef37b92021-12-02T14:38:43ZMacrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M10.1038/s41467-019-10859-w2041-1723https://doaj.org/article/71dda70f0fa943e6abde76eae9ef37b92019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10859-whttps://doaj.org/toc/2041-1723Fibrosis is a hallmark of several cardiac pathologies and its underlying mechanisms are still poorly defined. Here the authors show that macrophage hypoxia signaling following transverse aortic constriction in mice suppresses the activation of cardiac fibroblasts by secreting oncostatin M.Hajime AbeNorihiko TakedaTakayuki IsagawaHiroaki SembaSatoshi NishimuraMasaki Suimye MoriokaYu NakagamaTatsuyuki SatoKatsura SomaKatsuhiro KoyamaMasaki WakeManami KatohMasataka AsagiriMichael L. NeugentJung-whan KimChristian StockmannTomo YonezawaRyo InuzukaYasushi HirotaKoji MaemuraTakeshi YamashitaKinya OtsuIchiro ManabeRyozo NagaiIssei KomuroNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hajime Abe Norihiko Takeda Takayuki Isagawa Hiroaki Semba Satoshi Nishimura Masaki Suimye Morioka Yu Nakagama Tatsuyuki Sato Katsura Soma Katsuhiro Koyama Masaki Wake Manami Katoh Masataka Asagiri Michael L. Neugent Jung-whan Kim Christian Stockmann Tomo Yonezawa Ryo Inuzuka Yasushi Hirota Koji Maemura Takeshi Yamashita Kinya Otsu Ichiro Manabe Ryozo Nagai Issei Komuro Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M
description	Fibrosis is a hallmark of several cardiac pathologies and its underlying mechanisms are still poorly defined. Here the authors show that macrophage hypoxia signaling following transverse aortic constriction in mice suppresses the activation of cardiac fibroblasts by secreting oncostatin M.
format	article
author	Hajime Abe Norihiko Takeda Takayuki Isagawa Hiroaki Semba Satoshi Nishimura Masaki Suimye Morioka Yu Nakagama Tatsuyuki Sato Katsura Soma Katsuhiro Koyama Masaki Wake Manami Katoh Masataka Asagiri Michael L. Neugent Jung-whan Kim Christian Stockmann Tomo Yonezawa Ryo Inuzuka Yasushi Hirota Koji Maemura Takeshi Yamashita Kinya Otsu Ichiro Manabe Ryozo Nagai Issei Komuro
author_facet	Hajime Abe Norihiko Takeda Takayuki Isagawa Hiroaki Semba Satoshi Nishimura Masaki Suimye Morioka Yu Nakagama Tatsuyuki Sato Katsura Soma Katsuhiro Koyama Masaki Wake Manami Katoh Masataka Asagiri Michael L. Neugent Jung-whan Kim Christian Stockmann Tomo Yonezawa Ryo Inuzuka Yasushi Hirota Koji Maemura Takeshi Yamashita Kinya Otsu Ichiro Manabe Ryozo Nagai Issei Komuro
author_sort	Hajime Abe
title	Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M
title_short	Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M
title_full	Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M
title_fullStr	Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M
title_full_unstemmed	Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M
title_sort	macrophage hypoxia signaling regulates cardiac fibrosis via oncostatin m
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/71dda70f0fa943e6abde76eae9ef37b9
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Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

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