Patients in chronic prednisone use in a Brazilian municipality: are potential adverse events being monitored?

Introduction: chronic use of corticosteroids can trigger several adverse effects with changes in glycemic, lipid, liver enzymes and electrolyte levels. Therefore, the the aim of the present study was to analyze if the patients on chronic prednisone use from the Brazilian Public Health System (PHS)...

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Autores principales:	Virgínia M. Bolina, Thays S. Mendonça, Mariana L. Pereira, Caroline P. Domingueti, João P. Rodrigues, Tiago M. Reis, André Oliveira Baldoni
Formato:	article
Lenguaje:	EN PT
Publicado:	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde 2020
Materias:	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/71de3191bf954d0894f974a752565640
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spelling	oai:doaj.org-article:71de3191bf954d0894f974a7525656402021-11-28T02:46:11ZPatients in chronic prednisone use in a Brazilian municipality: are potential adverse events being monitored?10.30968/rbfhss.2019.104.03432179-59242316-7750https://doaj.org/article/71de3191bf954d0894f974a7525656402020-03-01T00:00:00Zhttps://www.rbfhss.org.br/sbrafh/article/view/343https://doaj.org/toc/2179-5924https://doaj.org/toc/2316-7750 Introduction: chronic use of corticosteroids can trigger several adverse effects with changes in glycemic, lipid, liver enzymes and electrolyte levels. Therefore, the the aim of the present study was to analyze if the patients on chronic prednisone use from the Brazilian Public Health System (PHS) in a Midwestern municipality of the state of Minas Gerais were monitored for their adverse effects through laboratory tests. Methods: a longitudinal descriptive study was carried out with retrospective data from patients attended by the PHS of this city, and who have used prednisone chronically for three consecutive years, from 2014 to 2016. The frequency of patients who underwent tests to monitor adverse events from the chronic use of prednisone was verified through electronic records in the Integrated Health System (IHS). The following types of tests were analyzed: total serum calcium, urine calcium (24-hour urine), serum phosphate, alkaline phosphatase, fasting glucose, sodium (Na+), potassium (K+), and lipidogram (triglycerides, LDL, VLDL, HDL, and total cholesterol). Results: it was observed that fasting glucose and lipidogram were the tests that presented the highest number of annual records. However, for the other examined parameters, which are essential for the follow-up of patients in chronic use of corticosteroids, the non-monitoring index is greater than 80 %. Conclusions: the results revealed an inadequate frequency of laboratory monitoring of patients in chronic prednisone use, indicating the occurrence of prescriptions without the monitoring of possible adverse effects, which may constitute safety problems for patients. Virgínia M. BolinaThays S. MendonçaMariana L. PereiraCaroline P. DominguetiJoão P. RodriguesTiago M. ReisAndré Oliveira BaldoniSociedade Brasileira de Farmácia Hospitalar e Serviços de SaúdearticlePublic aspects of medicineRA1-1270Pharmacy and materia medicaRS1-441Therapeutics. PharmacologyRM1-950ENPTRevista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 10, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN PT
topic	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950
spellingShingle	Public aspects of medicine RA1-1270 Pharmacy and materia medica RS1-441 Therapeutics. Pharmacology RM1-950 Virgínia M. Bolina Thays S. Mendonça Mariana L. Pereira Caroline P. Domingueti João P. Rodrigues Tiago M. Reis André Oliveira Baldoni Patients in chronic prednisone use in a Brazilian municipality: are potential adverse events being monitored?
description	Introduction: chronic use of corticosteroids can trigger several adverse effects with changes in glycemic, lipid, liver enzymes and electrolyte levels. Therefore, the the aim of the present study was to analyze if the patients on chronic prednisone use from the Brazilian Public Health System (PHS) in a Midwestern municipality of the state of Minas Gerais were monitored for their adverse effects through laboratory tests. Methods: a longitudinal descriptive study was carried out with retrospective data from patients attended by the PHS of this city, and who have used prednisone chronically for three consecutive years, from 2014 to 2016. The frequency of patients who underwent tests to monitor adverse events from the chronic use of prednisone was verified through electronic records in the Integrated Health System (IHS). The following types of tests were analyzed: total serum calcium, urine calcium (24-hour urine), serum phosphate, alkaline phosphatase, fasting glucose, sodium (Na+), potassium (K+), and lipidogram (triglycerides, LDL, VLDL, HDL, and total cholesterol). Results: it was observed that fasting glucose and lipidogram were the tests that presented the highest number of annual records. However, for the other examined parameters, which are essential for the follow-up of patients in chronic use of corticosteroids, the non-monitoring index is greater than 80 %. Conclusions: the results revealed an inadequate frequency of laboratory monitoring of patients in chronic prednisone use, indicating the occurrence of prescriptions without the monitoring of possible adverse effects, which may constitute safety problems for patients.
format	article
author	Virgínia M. Bolina Thays S. Mendonça Mariana L. Pereira Caroline P. Domingueti João P. Rodrigues Tiago M. Reis André Oliveira Baldoni
author_facet	Virgínia M. Bolina Thays S. Mendonça Mariana L. Pereira Caroline P. Domingueti João P. Rodrigues Tiago M. Reis André Oliveira Baldoni
author_sort	Virgínia M. Bolina
title	Patients in chronic prednisone use in a Brazilian municipality: are potential adverse events being monitored?
title_short	Patients in chronic prednisone use in a Brazilian municipality: are potential adverse events being monitored?
title_full	Patients in chronic prednisone use in a Brazilian municipality: are potential adverse events being monitored?
title_fullStr	Patients in chronic prednisone use in a Brazilian municipality: are potential adverse events being monitored?
title_full_unstemmed	Patients in chronic prednisone use in a Brazilian municipality: are potential adverse events being monitored?
title_sort	patients in chronic prednisone use in a brazilian municipality: are potential adverse events being monitored?
publisher	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
publishDate	2020
url	https://doaj.org/article/71de3191bf954d0894f974a752565640
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_version_	1718408445083779072

Patients in chronic prednisone use in a Brazilian municipality: are potential adverse events being monitored?

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