Characteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study

Characteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study

Sherif M Hamdy,1 Maged Abdel-Naseer,1 Nevin M Shalaby,1 Alaa N Elmazny,1 Ahmed A Nemr,2 Amr Hassan,1 Mohamed I Hegazy,1 Husam S Mourad,1 Nirmeen A Kishk,1 Mona A Nada,1 Ahmed Abdelalim,1 Amr M Fouad,1 Hatem S Shehata1 1Neurology Department, Cairo University, 2Neurology Department, Maadi Military Ho...

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Autores principales: Hamdy SM, Abdel-Naseer M, Shalaby NM, Elmazny AN, Nemr AA, Hassan A, Hegazy MI, Mourad HS, Kishk NA, Nada MA, Abdelalim A, Fouad AM, Shehata HS
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Multiple sclerosis
MS registry
Epidemiology
Middle East
North Africa
Egypt.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/71e0abf9eb734a0da2a89a6e171763e3
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spelling oai:doaj.org-article:71e0abf9eb734a0da2a89a6e171763e32021-12-02T08:18:25ZCharacteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study1178-2021https://doaj.org/article/71e0abf9eb734a0da2a89a6e171763e32017-07-01T00:00:00Zhttps://www.dovepress.com/characteristics-and-predictors-of-progression-in-an-egyptian-multiple--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Sherif M Hamdy,1 Maged Abdel-Naseer,1 Nevin M Shalaby,1 Alaa N Elmazny,1 Ahmed A Nemr,2 Amr Hassan,1 Mohamed I Hegazy,1 Husam S Mourad,1 Nirmeen A Kishk,1 Mona A Nada,1 Ahmed Abdelalim,1 Amr M Fouad,1 Hatem S Shehata1 1Neurology Department, Cairo University, 2Neurology Department, Maadi Military Hospital, Cairo, Egypt Background: Multiple sclerosis (MS) is a complex autoimmune disease with a heterogeneous presentation and diverse disease course. Recent studies indicate a rising prevalence of MS in the Middle East.Objective: To characterize the demographics and disease features of Egyptian patients attending four tertiary referral MS centers in Cairo.Materials and methods: This was a retrospective, observational study on 1,581 patients between 2001 and 2015. Medical records were reviewed and data were identified and extracted in a standardized electronic registry.Results: The mean age of disease onset was 26.6±7.8 years, with the majority being female (2.11:1). Relapsing–remitting MS was the most common type (75.1%). The main presenting symptom was motor weakness (43.9%), which was also the most frequent symptom during the disease course. Family history of MS was found in 2.28%. Higher initial Expanded Disability Status Scale score, black holes, and infratentorial lesions on initial magnetic resonance imaging were independent factors for disease progression by univariate analysis (OR 3.87 [95% CI 1.84–6.51], 4.14 [95% CI 3.08–5.58], 4.07 [95% CI 3.21–4.99], respectively); however, in multivariate analysis, only infratentorial lesions were an independent risk for disease progression (OR 6, 95% CI 2.99–12.02; P=0.0005).Conclusion: The results from this registry – the largest for MS in the Arab region to date – are comparable to other registries with slight differences. Keywords: multiple sclerosis, MS registry, epidemiology, Middle East, North Africa, Egypt Hamdy SMAbdel-Naseer MShalaby NMElmazny ANNemr AAHassan AHegazy MIMourad HSKishk NANada MAAbdelalim AFouad AMShehata HSDove Medical PressarticleMultiple sclerosisMS registryEpidemiologyMiddle EastNorth AfricaEgypt.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1895-1903 (2017)
institution DOAJ
collection DOAJ
language EN
topic Multiple sclerosis
MS registry
Epidemiology
Middle East
North Africa
Egypt.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Multiple sclerosis
MS registry
Epidemiology
Middle East
North Africa
Egypt.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Hamdy SM
Abdel-Naseer M
Shalaby NM
Elmazny AN
Nemr AA
Hassan A
Hegazy MI
Mourad HS
Kishk NA
Nada MA
Abdelalim A
Fouad AM
Shehata HS
Characteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study
description Sherif M Hamdy,1 Maged Abdel-Naseer,1 Nevin M Shalaby,1 Alaa N Elmazny,1 Ahmed A Nemr,2 Amr Hassan,1 Mohamed I Hegazy,1 Husam S Mourad,1 Nirmeen A Kishk,1 Mona A Nada,1 Ahmed Abdelalim,1 Amr M Fouad,1 Hatem S Shehata1 1Neurology Department, Cairo University, 2Neurology Department, Maadi Military Hospital, Cairo, Egypt Background: Multiple sclerosis (MS) is a complex autoimmune disease with a heterogeneous presentation and diverse disease course. Recent studies indicate a rising prevalence of MS in the Middle East.Objective: To characterize the demographics and disease features of Egyptian patients attending four tertiary referral MS centers in Cairo.Materials and methods: This was a retrospective, observational study on 1,581 patients between 2001 and 2015. Medical records were reviewed and data were identified and extracted in a standardized electronic registry.Results: The mean age of disease onset was 26.6±7.8 years, with the majority being female (2.11:1). Relapsing–remitting MS was the most common type (75.1%). The main presenting symptom was motor weakness (43.9%), which was also the most frequent symptom during the disease course. Family history of MS was found in 2.28%. Higher initial Expanded Disability Status Scale score, black holes, and infratentorial lesions on initial magnetic resonance imaging were independent factors for disease progression by univariate analysis (OR 3.87 [95% CI 1.84–6.51], 4.14 [95% CI 3.08–5.58], 4.07 [95% CI 3.21–4.99], respectively); however, in multivariate analysis, only infratentorial lesions were an independent risk for disease progression (OR 6, 95% CI 2.99–12.02; P=0.0005).Conclusion: The results from this registry – the largest for MS in the Arab region to date – are comparable to other registries with slight differences. Keywords: multiple sclerosis, MS registry, epidemiology, Middle East, North Africa, Egypt 
format article
author Hamdy SM
Abdel-Naseer M
Shalaby NM
Elmazny AN
Nemr AA
Hassan A
Hegazy MI
Mourad HS
Kishk NA
Nada MA
Abdelalim A
Fouad AM
Shehata HS
author_facet Hamdy SM
Abdel-Naseer M
Shalaby NM
Elmazny AN
Nemr AA
Hassan A
Hegazy MI
Mourad HS
Kishk NA
Nada MA
Abdelalim A
Fouad AM
Shehata HS
author_sort Hamdy SM
title Characteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study
title_short Characteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study
title_full Characteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study
title_fullStr Characteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study
title_full_unstemmed Characteristics and predictors of progression in an Egyptian multiple sclerosis cohort: a multicenter registry study
title_sort characteristics and predictors of progression in an egyptian multiple sclerosis cohort: a multicenter registry study
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/71e0abf9eb734a0da2a89a6e171763e3
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