Energy-protective function of plant composition in the experimental dyslipoproteidemia
The influence of the plant composition on the functional state of rat hepatic mitochondria and biochemical indices of energy metabolism was studied. Experiments were carried out on 42 white Wistar rats. The application of the plant composition increases contingency between oxidation and phosphorylat...
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Scientific Сentre for Family Health and Human Reproduction Problems
2016
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oai:doaj.org-article:71e0ddab6c4a40b99e8472074f1a34cd2021-11-23T06:14:34ZEnergy-protective function of plant composition in the experimental dyslipoproteidemia2541-94202587-959610.12737/21597https://doaj.org/article/71e0ddab6c4a40b99e8472074f1a34cd2016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/224https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The influence of the plant composition on the functional state of rat hepatic mitochondria and biochemical indices of energy metabolism was studied. Experiments were carried out on 42 white Wistar rats. The application of the plant composition increases contingency between oxidation and phosphorylation, as well as coefficients of respiratory stimulation and respiratory control by 17 % (р < 0.05) and 15 % (р < 0.05) respectively as compared to the control group. The tested herbal medicine increases the ATP content by 29 % (р < 0.05) and improves the activity of pyruvate kinase and H+-ATPase by 1.9 and 1.2 times respectively which indicates a partial restoration of energy metabolism in hepatocytes. The results of the research allow us to recommend the plant compositionfor its further study as a potential prospective hypolipidemic remedy for non-alcoholic fatty liver disease.A. A. ToropovaY. G. RazuvaevaS. V. LemzaS. M. NikolaevN. V. VerlanA. Yu. ErentuevaScientific Сentre for Family Health and Human Reproduction Problemsarticledyslipoproteidemialivermitochondrionenergy metabolismphosphorylationoxidative stressadenylpyrophosphatepyruvate kinasehypolipidemic plant compositionScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(1), Pp 42-45 (2016) |
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DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
dyslipoproteidemia liver mitochondrion energy metabolism phosphorylation oxidative stress adenylpyrophosphate pyruvate kinase hypolipidemic plant composition Science Q |
| spellingShingle |
dyslipoproteidemia liver mitochondrion energy metabolism phosphorylation oxidative stress adenylpyrophosphate pyruvate kinase hypolipidemic plant composition Science Q A. A. Toropova Y. G. Razuvaeva S. V. Lemza S. M. Nikolaev N. V. Verlan A. Yu. Erentueva Energy-protective function of plant composition in the experimental dyslipoproteidemia |
| description |
The influence of the plant composition on the functional state of rat hepatic mitochondria and biochemical indices of energy metabolism was studied. Experiments were carried out on 42 white Wistar rats. The application of the plant composition increases contingency between oxidation and phosphorylation, as well as coefficients of respiratory stimulation and respiratory control by 17 % (р < 0.05) and 15 % (р < 0.05) respectively as compared to the control group. The tested herbal medicine increases the ATP content by 29 % (р < 0.05) and improves the activity of pyruvate kinase and H+-ATPase by 1.9 and 1.2 times respectively which indicates a partial restoration of energy metabolism in hepatocytes. The results of the research allow us to recommend the plant compositionfor its further study as a potential prospective hypolipidemic remedy for non-alcoholic fatty liver disease. |
| format |
article |
| author |
A. A. Toropova Y. G. Razuvaeva S. V. Lemza S. M. Nikolaev N. V. Verlan A. Yu. Erentueva |
| author_facet |
A. A. Toropova Y. G. Razuvaeva S. V. Lemza S. M. Nikolaev N. V. Verlan A. Yu. Erentueva |
| author_sort |
A. A. Toropova |
| title |
Energy-protective function of plant composition in the experimental dyslipoproteidemia |
| title_short |
Energy-protective function of plant composition in the experimental dyslipoproteidemia |
| title_full |
Energy-protective function of plant composition in the experimental dyslipoproteidemia |
| title_fullStr |
Energy-protective function of plant composition in the experimental dyslipoproteidemia |
| title_full_unstemmed |
Energy-protective function of plant composition in the experimental dyslipoproteidemia |
| title_sort |
energy-protective function of plant composition in the experimental dyslipoproteidemia |
| publisher |
Scientific Сentre for Family Health and Human Reproduction Problems |
| publishDate |
2016 |
| url |
https://doaj.org/article/71e0ddab6c4a40b99e8472074f1a34cd |
| work_keys_str_mv |
AT aatoropova energyprotectivefunctionofplantcompositionintheexperimentaldyslipoproteidemia AT ygrazuvaeva energyprotectivefunctionofplantcompositionintheexperimentaldyslipoproteidemia AT svlemza energyprotectivefunctionofplantcompositionintheexperimentaldyslipoproteidemia AT smnikolaev energyprotectivefunctionofplantcompositionintheexperimentaldyslipoproteidemia AT nvverlan energyprotectivefunctionofplantcompositionintheexperimentaldyslipoproteidemia AT ayuerentueva energyprotectivefunctionofplantcompositionintheexperimentaldyslipoproteidemia |
| _version_ |
1718417075616088064 |