Probiotics: their action against pathogens can be turned around
Abstract Probiotics when applied in complex evolving (micro-)ecosystems, might be selectively beneficial or detrimental to pathogens when their prophylactic efficacies are prone to ambient interactions. Here, we document a counter-intuitive phenomenon that probiotic-treated zebrafish (Danio rerio) w...
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2021
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oai:doaj.org-article:71e4436878a04c009dae25625df4ed7f2021-12-02T17:14:30ZProbiotics: their action against pathogens can be turned around10.1038/s41598-021-91542-32045-2322https://doaj.org/article/71e4436878a04c009dae25625df4ed7f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91542-3https://doaj.org/toc/2045-2322Abstract Probiotics when applied in complex evolving (micro-)ecosystems, might be selectively beneficial or detrimental to pathogens when their prophylactic efficacies are prone to ambient interactions. Here, we document a counter-intuitive phenomenon that probiotic-treated zebrafish (Danio rerio) were respectively healthy at higher but succumbed at lower level of challenge with a pathogenic Vibrio isolate. This was confirmed by prominent dissimilarities in fish survival and histology. Based upon the profiling of the zebrafish microbiome, and the probiotic and the pathogen shared gene orthogroups (genetic niche overlaps in genomes), this consequently might have modified the probiotic metabolome as well as the virulence of the pathogen. Although it did not reshuffle the architecture of the commensal microbiome of the vertebrate host, it might have altered the probiotic-pathogen inter-genus and intra-species communications. Such in-depth analyses are needed to avoid counteractive phenomena of probiotics and to optimise their efficacies to magnify human and animal well-being. Moreover, such studies will be valuable to improve the relevant guidelines published by organisations such as FAO, OIE and WHO.Lian GanWei-Hua XuYuanyan XiongZhaolin LvJianwei ZhengYu ZhangJianhao LinJingshu LiuShijun ChenMengqiu ChenQingqi GuoJunfeng WuJingjie ChenZhenhua SuJijia SunYuhui HeChuanhe LiuWeifang WangWilly VerstraetePatrick SorgeloosTom DefoirdtQiwei QinYiying LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021) |
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Medicine R Science Q Lian Gan Wei-Hua Xu Yuanyan Xiong Zhaolin Lv Jianwei Zheng Yu Zhang Jianhao Lin Jingshu Liu Shijun Chen Mengqiu Chen Qingqi Guo Junfeng Wu Jingjie Chen Zhenhua Su Jijia Sun Yuhui He Chuanhe Liu Weifang Wang Willy Verstraete Patrick Sorgeloos Tom Defoirdt Qiwei Qin Yiying Liu Probiotics: their action against pathogens can be turned around |
| description |
Abstract Probiotics when applied in complex evolving (micro-)ecosystems, might be selectively beneficial or detrimental to pathogens when their prophylactic efficacies are prone to ambient interactions. Here, we document a counter-intuitive phenomenon that probiotic-treated zebrafish (Danio rerio) were respectively healthy at higher but succumbed at lower level of challenge with a pathogenic Vibrio isolate. This was confirmed by prominent dissimilarities in fish survival and histology. Based upon the profiling of the zebrafish microbiome, and the probiotic and the pathogen shared gene orthogroups (genetic niche overlaps in genomes), this consequently might have modified the probiotic metabolome as well as the virulence of the pathogen. Although it did not reshuffle the architecture of the commensal microbiome of the vertebrate host, it might have altered the probiotic-pathogen inter-genus and intra-species communications. Such in-depth analyses are needed to avoid counteractive phenomena of probiotics and to optimise their efficacies to magnify human and animal well-being. Moreover, such studies will be valuable to improve the relevant guidelines published by organisations such as FAO, OIE and WHO. |
| format |
article |
| author |
Lian Gan Wei-Hua Xu Yuanyan Xiong Zhaolin Lv Jianwei Zheng Yu Zhang Jianhao Lin Jingshu Liu Shijun Chen Mengqiu Chen Qingqi Guo Junfeng Wu Jingjie Chen Zhenhua Su Jijia Sun Yuhui He Chuanhe Liu Weifang Wang Willy Verstraete Patrick Sorgeloos Tom Defoirdt Qiwei Qin Yiying Liu |
| author_facet |
Lian Gan Wei-Hua Xu Yuanyan Xiong Zhaolin Lv Jianwei Zheng Yu Zhang Jianhao Lin Jingshu Liu Shijun Chen Mengqiu Chen Qingqi Guo Junfeng Wu Jingjie Chen Zhenhua Su Jijia Sun Yuhui He Chuanhe Liu Weifang Wang Willy Verstraete Patrick Sorgeloos Tom Defoirdt Qiwei Qin Yiying Liu |
| author_sort |
Lian Gan |
| title |
Probiotics: their action against pathogens can be turned around |
| title_short |
Probiotics: their action against pathogens can be turned around |
| title_full |
Probiotics: their action against pathogens can be turned around |
| title_fullStr |
Probiotics: their action against pathogens can be turned around |
| title_full_unstemmed |
Probiotics: their action against pathogens can be turned around |
| title_sort |
probiotics: their action against pathogens can be turned around |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/71e4436878a04c009dae25625df4ed7f |
| work_keys_str_mv |
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