Prevalence of antimicrobial resistance and its clinical implications in Ethiopia: a systematic review

Abstract Background Antimicrobial resistance is one of the major public health challenges in Ethiopia. However, there is no comprehensive summary of existing AMR data in the country. Aim To determine the prevalence of antimicrobial resistance and its clinical implications in Ethiopia. Methods A syst...

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Autores principales:	Derbew Fikadu Berhe, Getachew Tesfaye Beyene, Berhanu Seyoum, Meseret Gebre, Kassa Haile, Mulugeta Tsegaye, Minyahil Tadesse Boltena, Emawayish Tesema, Taddele Cherinet Kibret, Mulatu Biru, Dawd S. Siraj, Daniel Shirley, Rawleigh Howe, Alemseged Abdissa
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Antibacterial resistance Antibiotic resistance Drug resistance Systematic review Ethiopia Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/71e7ed31dc83400c824ac5432f1c29a6
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spelling	oai:doaj.org-article:71e7ed31dc83400c824ac5432f1c29a62021-12-05T12:24:04ZPrevalence of antimicrobial resistance and its clinical implications in Ethiopia: a systematic review10.1186/s13756-021-00965-02047-2994https://doaj.org/article/71e7ed31dc83400c824ac5432f1c29a62021-12-01T00:00:00Zhttps://doi.org/10.1186/s13756-021-00965-0https://doaj.org/toc/2047-2994Abstract Background Antimicrobial resistance is one of the major public health challenges in Ethiopia. However, there is no comprehensive summary of existing AMR data in the country. Aim To determine the prevalence of antimicrobial resistance and its clinical implications in Ethiopia. Methods A systematic literature search was performed on the PubMed/Medline database. Original studies on antimicrobial resistance conducted in Ethiopia between 1st January 2009 and 31st July 2019 were included. The outcome measure was the number of isolates resistant to antimicrobial agents in terms of specific pathogens, and disease condition. Data was calculated as total number of resistant isolates relative to the total number of isolates per specific pathogen and medication. Results A total of 48,021 study participants enrolled from 131 original studies were included resulting in 15,845 isolates tested for antimicrobial resistance. The most common clinical sample sources were urine (28%), ear, nose, and throat discharge collectively (27%), and blood (21%). All the studies were cross-sectional and 83% were conducted in hospital settings. Among Gram-positive bacteria, the reported level of resistance to vancomycin ranged from 8% (Enterococcus species) to 20% (S. aureus). E. coli, K. pneumoniae and P. aeruginosa were the most common Gram-negative pathogens resistant to key antimicrobial agents described in the national standard treatment guideline and were associated with diverse clinical conditions: urinary tract infections, diarrhea, surgical site infections, pneumonia, ocular infections, and middle ear infections. Conclusion Overall, there is a high prevalence of antimicrobial resistance in Ethiopia. Empirical treatment of bacterial infections needs to be guided by up-to-date national guidelines considering local antimicrobial susceptibility patterns. Equipping diagnostic laboratories with culture and drug susceptibility testing facilities, and establishing a strong antimicrobial stewardship program should be high priorities.Derbew Fikadu BerheGetachew Tesfaye BeyeneBerhanu SeyoumMeseret GebreKassa HaileMulugeta TsegayeMinyahil Tadesse BoltenaEmawayish TesemaTaddele Cherinet KibretMulatu BiruDawd S. SirajDaniel ShirleyRawleigh HoweAlemseged AbdissaBMCarticleAntibacterial resistanceAntibiotic resistanceDrug resistanceSystematic reviewEthiopiaInfectious and parasitic diseasesRC109-216ENAntimicrobial Resistance and Infection Control, Vol 10, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antibacterial resistance Antibiotic resistance Drug resistance Systematic review Ethiopia Infectious and parasitic diseases RC109-216
spellingShingle	Antibacterial resistance Antibiotic resistance Drug resistance Systematic review Ethiopia Infectious and parasitic diseases RC109-216 Derbew Fikadu Berhe Getachew Tesfaye Beyene Berhanu Seyoum Meseret Gebre Kassa Haile Mulugeta Tsegaye Minyahil Tadesse Boltena Emawayish Tesema Taddele Cherinet Kibret Mulatu Biru Dawd S. Siraj Daniel Shirley Rawleigh Howe Alemseged Abdissa Prevalence of antimicrobial resistance and its clinical implications in Ethiopia: a systematic review
description	Abstract Background Antimicrobial resistance is one of the major public health challenges in Ethiopia. However, there is no comprehensive summary of existing AMR data in the country. Aim To determine the prevalence of antimicrobial resistance and its clinical implications in Ethiopia. Methods A systematic literature search was performed on the PubMed/Medline database. Original studies on antimicrobial resistance conducted in Ethiopia between 1st January 2009 and 31st July 2019 were included. The outcome measure was the number of isolates resistant to antimicrobial agents in terms of specific pathogens, and disease condition. Data was calculated as total number of resistant isolates relative to the total number of isolates per specific pathogen and medication. Results A total of 48,021 study participants enrolled from 131 original studies were included resulting in 15,845 isolates tested for antimicrobial resistance. The most common clinical sample sources were urine (28%), ear, nose, and throat discharge collectively (27%), and blood (21%). All the studies were cross-sectional and 83% were conducted in hospital settings. Among Gram-positive bacteria, the reported level of resistance to vancomycin ranged from 8% (Enterococcus species) to 20% (S. aureus). E. coli, K. pneumoniae and P. aeruginosa were the most common Gram-negative pathogens resistant to key antimicrobial agents described in the national standard treatment guideline and were associated with diverse clinical conditions: urinary tract infections, diarrhea, surgical site infections, pneumonia, ocular infections, and middle ear infections. Conclusion Overall, there is a high prevalence of antimicrobial resistance in Ethiopia. Empirical treatment of bacterial infections needs to be guided by up-to-date national guidelines considering local antimicrobial susceptibility patterns. Equipping diagnostic laboratories with culture and drug susceptibility testing facilities, and establishing a strong antimicrobial stewardship program should be high priorities.
format	article
author	Derbew Fikadu Berhe Getachew Tesfaye Beyene Berhanu Seyoum Meseret Gebre Kassa Haile Mulugeta Tsegaye Minyahil Tadesse Boltena Emawayish Tesema Taddele Cherinet Kibret Mulatu Biru Dawd S. Siraj Daniel Shirley Rawleigh Howe Alemseged Abdissa
author_facet	Derbew Fikadu Berhe Getachew Tesfaye Beyene Berhanu Seyoum Meseret Gebre Kassa Haile Mulugeta Tsegaye Minyahil Tadesse Boltena Emawayish Tesema Taddele Cherinet Kibret Mulatu Biru Dawd S. Siraj Daniel Shirley Rawleigh Howe Alemseged Abdissa
author_sort	Derbew Fikadu Berhe
title	Prevalence of antimicrobial resistance and its clinical implications in Ethiopia: a systematic review
title_short	Prevalence of antimicrobial resistance and its clinical implications in Ethiopia: a systematic review
title_full	Prevalence of antimicrobial resistance and its clinical implications in Ethiopia: a systematic review
title_fullStr	Prevalence of antimicrobial resistance and its clinical implications in Ethiopia: a systematic review
title_full_unstemmed	Prevalence of antimicrobial resistance and its clinical implications in Ethiopia: a systematic review
title_sort	prevalence of antimicrobial resistance and its clinical implications in ethiopia: a systematic review
publisher	BMC
publishDate	2021
url	https://doaj.org/article/71e7ed31dc83400c824ac5432f1c29a6
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Prevalence of antimicrobial resistance and its clinical implications in Ethiopia: a systematic review

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