Circulating tumor cells: biology and clinical significance

Abstract Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis. Detecting these very...

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Autores principales:	Danfeng Lin, Lesang Shen, Meng Luo, Kun Zhang, Jinfan Li, Qi Yang, Fangfang Zhu, Dan Zhou, Shu Zheng, Yiding Chen, Jiaojiao Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/71ea536e4bb44b609f437d7e1f6f4ba9
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spelling	oai:doaj.org-article:71ea536e4bb44b609f437d7e1f6f4ba92021-11-28T12:08:40ZCirculating tumor cells: biology and clinical significance10.1038/s41392-021-00817-82059-3635https://doaj.org/article/71ea536e4bb44b609f437d7e1f6f4ba92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41392-021-00817-8https://doaj.org/toc/2059-3635Abstract Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis. Detecting these very rare CTCs among the massive blood cells is challenging. However, emerging technologies for CTCs detection have profoundly contributed to deepening investigation into the biology of CTCs and have facilitated their clinical application. Current technologies for the detection of CTCs are summarized herein, together with their advantages and disadvantages. The detection of CTCs is usually dependent on molecular markers, with the epithelial cell adhesion molecule being the most widely used, although molecular markers vary between different types of cancer. Properties associated with epithelial-to-mesenchymal transition and stemness have been identified in CTCs, indicating their increased metastatic capacity. Only a small proportion of CTCs can survive and eventually initiate metastases, suggesting that an interaction and modulation between CTCs and the hostile blood microenvironment is essential for CTC metastasis. Single-cell sequencing of CTCs has been extensively investigated, and has enabled researchers to reveal the genome and transcriptome of CTCs. Herein, we also review the clinical applications of CTCs, especially for monitoring response to cancer treatment and in evaluating prognosis. Hence, CTCs have and will continue to contribute to providing significant insights into metastatic processes and will open new avenues for useful clinical applications.Danfeng LinLesang ShenMeng LuoKun ZhangJinfan LiQi YangFangfang ZhuDan ZhouShu ZhengYiding ChenJiaojiao ZhouNature Publishing GrouparticleMedicineRBiology (General)QH301-705.5ENSignal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-24 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biology (General) QH301-705.5
spellingShingle	Medicine R Biology (General) QH301-705.5 Danfeng Lin Lesang Shen Meng Luo Kun Zhang Jinfan Li Qi Yang Fangfang Zhu Dan Zhou Shu Zheng Yiding Chen Jiaojiao Zhou Circulating tumor cells: biology and clinical significance
description	Abstract Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis. Detecting these very rare CTCs among the massive blood cells is challenging. However, emerging technologies for CTCs detection have profoundly contributed to deepening investigation into the biology of CTCs and have facilitated their clinical application. Current technologies for the detection of CTCs are summarized herein, together with their advantages and disadvantages. The detection of CTCs is usually dependent on molecular markers, with the epithelial cell adhesion molecule being the most widely used, although molecular markers vary between different types of cancer. Properties associated with epithelial-to-mesenchymal transition and stemness have been identified in CTCs, indicating their increased metastatic capacity. Only a small proportion of CTCs can survive and eventually initiate metastases, suggesting that an interaction and modulation between CTCs and the hostile blood microenvironment is essential for CTC metastasis. Single-cell sequencing of CTCs has been extensively investigated, and has enabled researchers to reveal the genome and transcriptome of CTCs. Herein, we also review the clinical applications of CTCs, especially for monitoring response to cancer treatment and in evaluating prognosis. Hence, CTCs have and will continue to contribute to providing significant insights into metastatic processes and will open new avenues for useful clinical applications.
format	article
author	Danfeng Lin Lesang Shen Meng Luo Kun Zhang Jinfan Li Qi Yang Fangfang Zhu Dan Zhou Shu Zheng Yiding Chen Jiaojiao Zhou
author_facet	Danfeng Lin Lesang Shen Meng Luo Kun Zhang Jinfan Li Qi Yang Fangfang Zhu Dan Zhou Shu Zheng Yiding Chen Jiaojiao Zhou
author_sort	Danfeng Lin
title	Circulating tumor cells: biology and clinical significance
title_short	Circulating tumor cells: biology and clinical significance
title_full	Circulating tumor cells: biology and clinical significance
title_fullStr	Circulating tumor cells: biology and clinical significance
title_full_unstemmed	Circulating tumor cells: biology and clinical significance
title_sort	circulating tumor cells: biology and clinical significance
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/71ea536e4bb44b609f437d7e1f6f4ba9
work_keys_str_mv	AT danfenglin circulatingtumorcellsbiologyandclinicalsignificance AT lesangshen circulatingtumorcellsbiologyandclinicalsignificance AT mengluo circulatingtumorcellsbiologyandclinicalsignificance AT kunzhang circulatingtumorcellsbiologyandclinicalsignificance AT jinfanli circulatingtumorcellsbiologyandclinicalsignificance AT qiyang circulatingtumorcellsbiologyandclinicalsignificance AT fangfangzhu circulatingtumorcellsbiologyandclinicalsignificance AT danzhou circulatingtumorcellsbiologyandclinicalsignificance AT shuzheng circulatingtumorcellsbiologyandclinicalsignificance AT yidingchen circulatingtumorcellsbiologyandclinicalsignificance AT jiaojiaozhou circulatingtumorcellsbiologyandclinicalsignificance
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Circulating tumor cells: biology and clinical significance

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