Detection of del(16q) using the CBFB-MYH11 translocation dual fusion probe

Del(16q) is an uncommon cytogenetic abnormality that can occur in different types of myeloid neoplasms. A small number of cases with del(16q) have been reported. Here, we report del(16q) in an adult patient with acute myelomonocytic leukemia (AMML). Examination of bone marrow aspirate smears and cyt...

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Autores principales:	Doaa F. Temerik, Walaa T. El-Mahdy, Ahmed Makboul Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	AMML CBFB-MYH11 Del(16q) FISH Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/71ecffbbcd0d4b2894045d05cecd69b5
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spelling	oai:doaj.org-article:71ecffbbcd0d4b2894045d05cecd69b52021-12-02T04:59:59ZDetection of del(16q) using the CBFB-MYH11 translocation dual fusion probe1658-387610.1016/j.hemonc.2020.02.001https://doaj.org/article/71ecffbbcd0d4b2894045d05cecd69b52021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1658387620300200https://doaj.org/toc/1658-3876Del(16q) is an uncommon cytogenetic abnormality that can occur in different types of myeloid neoplasms. A small number of cases with del(16q) have been reported. Here, we report del(16q) in an adult patient with acute myelomonocytic leukemia (AMML). Examination of bone marrow aspirate smears and cytochemical stains, and flow cytometric immunophenotyping diagnosed the case as AMML. Fluorescence in situ hybridization (FISH) for inv(16) was performed using the CBFB-MYH11 translocation dual fusion probe. Accidently, FISH analysis revealed a loss of 16q22 in most of the examined interphase cells, indicating the presence of del(16q). The CBFB-MYH11 translocation dual fusion probe can be very helpful in detecting del(16q).Doaa F. TemerikWalaa T. El-MahdyAhmed Makboul AhmedElsevierarticleAMMLCBFB-MYH11Del(16q)FISHDiseases of the blood and blood-forming organsRC633-647.5Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENHematology/Oncology and Stem Cell Therapy, Vol 14, Iss 4, Pp 351-352 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	AMML CBFB-MYH11 Del(16q) FISH Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	AMML CBFB-MYH11 Del(16q) FISH Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Doaa F. Temerik Walaa T. El-Mahdy Ahmed Makboul Ahmed Detection of del(16q) using the CBFB-MYH11 translocation dual fusion probe
description	Del(16q) is an uncommon cytogenetic abnormality that can occur in different types of myeloid neoplasms. A small number of cases with del(16q) have been reported. Here, we report del(16q) in an adult patient with acute myelomonocytic leukemia (AMML). Examination of bone marrow aspirate smears and cytochemical stains, and flow cytometric immunophenotyping diagnosed the case as AMML. Fluorescence in situ hybridization (FISH) for inv(16) was performed using the CBFB-MYH11 translocation dual fusion probe. Accidently, FISH analysis revealed a loss of 16q22 in most of the examined interphase cells, indicating the presence of del(16q). The CBFB-MYH11 translocation dual fusion probe can be very helpful in detecting del(16q).
format	article
author	Doaa F. Temerik Walaa T. El-Mahdy Ahmed Makboul Ahmed
author_facet	Doaa F. Temerik Walaa T. El-Mahdy Ahmed Makboul Ahmed
author_sort	Doaa F. Temerik
title	Detection of del(16q) using the CBFB-MYH11 translocation dual fusion probe
title_short	Detection of del(16q) using the CBFB-MYH11 translocation dual fusion probe
title_full	Detection of del(16q) using the CBFB-MYH11 translocation dual fusion probe
title_fullStr	Detection of del(16q) using the CBFB-MYH11 translocation dual fusion probe
title_full_unstemmed	Detection of del(16q) using the CBFB-MYH11 translocation dual fusion probe
title_sort	detection of del(16q) using the cbfb-myh11 translocation dual fusion probe
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/71ecffbbcd0d4b2894045d05cecd69b5
work_keys_str_mv	AT doaaftemerik detectionofdel16qusingthecbfbmyh11translocationdualfusionprobe AT walaatelmahdy detectionofdel16qusingthecbfbmyh11translocationdualfusionprobe AT ahmedmakboulahmed detectionofdel16qusingthecbfbmyh11translocationdualfusionprobe
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Detection of del(16q) using the CBFB-MYH11 translocation dual fusion probe

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