LGR5 marks targetable tumor-initiating cells in mouse liver cancer

Cancer stem cells (CSCs) are thought to be the main drivers for disease progression and treatment resistance in liver cancer. This study identifies the LGR5+ compartment as an important CSC population, representing a viable therapeutic target for combating liver cancer.

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Autores principales:	Wanlu Cao, Meng Li, Jiaye Liu, Shaoshi Zhang, Lisanne Noordam, Monique M. A. Verstegen, Ling Wang, Buyun Ma, Shan Li, Wenshi Wang, Michiel Bolkestein, Michael Doukas, Kan Chen, Zhongren Ma, Marco Bruno, Dave Sprengers, Jaap Kwekkeboom, Luc J. W. van der Laan, Ron Smits, Maikel P. Peppelenbosch, Qiuwei Pan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71ee0de1c34f4f6fa934afafed4f5a27
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spelling	oai:doaj.org-article:71ee0de1c34f4f6fa934afafed4f5a272021-12-02T14:42:46ZLGR5 marks targetable tumor-initiating cells in mouse liver cancer10.1038/s41467-020-15846-02041-1723https://doaj.org/article/71ee0de1c34f4f6fa934afafed4f5a272020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15846-0https://doaj.org/toc/2041-1723Cancer stem cells (CSCs) are thought to be the main drivers for disease progression and treatment resistance in liver cancer. This study identifies the LGR5+ compartment as an important CSC population, representing a viable therapeutic target for combating liver cancer.Wanlu CaoMeng LiJiaye LiuShaoshi ZhangLisanne NoordamMonique M. A. VerstegenLing WangBuyun MaShan LiWenshi WangMichiel BolkesteinMichael DoukasKan ChenZhongren MaMarco BrunoDave SprengersJaap KwekkeboomLuc J. W. van der LaanRon SmitsMaikel P. PeppelenboschQiuwei PanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wanlu Cao Meng Li Jiaye Liu Shaoshi Zhang Lisanne Noordam Monique M. A. Verstegen Ling Wang Buyun Ma Shan Li Wenshi Wang Michiel Bolkestein Michael Doukas Kan Chen Zhongren Ma Marco Bruno Dave Sprengers Jaap Kwekkeboom Luc J. W. van der Laan Ron Smits Maikel P. Peppelenbosch Qiuwei Pan LGR5 marks targetable tumor-initiating cells in mouse liver cancer
description	Cancer stem cells (CSCs) are thought to be the main drivers for disease progression and treatment resistance in liver cancer. This study identifies the LGR5+ compartment as an important CSC population, representing a viable therapeutic target for combating liver cancer.
format	article
author	Wanlu Cao Meng Li Jiaye Liu Shaoshi Zhang Lisanne Noordam Monique M. A. Verstegen Ling Wang Buyun Ma Shan Li Wenshi Wang Michiel Bolkestein Michael Doukas Kan Chen Zhongren Ma Marco Bruno Dave Sprengers Jaap Kwekkeboom Luc J. W. van der Laan Ron Smits Maikel P. Peppelenbosch Qiuwei Pan
author_facet	Wanlu Cao Meng Li Jiaye Liu Shaoshi Zhang Lisanne Noordam Monique M. A. Verstegen Ling Wang Buyun Ma Shan Li Wenshi Wang Michiel Bolkestein Michael Doukas Kan Chen Zhongren Ma Marco Bruno Dave Sprengers Jaap Kwekkeboom Luc J. W. van der Laan Ron Smits Maikel P. Peppelenbosch Qiuwei Pan
author_sort	Wanlu Cao
title	LGR5 marks targetable tumor-initiating cells in mouse liver cancer
title_short	LGR5 marks targetable tumor-initiating cells in mouse liver cancer
title_full	LGR5 marks targetable tumor-initiating cells in mouse liver cancer
title_fullStr	LGR5 marks targetable tumor-initiating cells in mouse liver cancer
title_full_unstemmed	LGR5 marks targetable tumor-initiating cells in mouse liver cancer
title_sort	lgr5 marks targetable tumor-initiating cells in mouse liver cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/71ee0de1c34f4f6fa934afafed4f5a27
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LGR5 marks targetable tumor-initiating cells in mouse liver cancer

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